| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6868 |
Name | ADAM17 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for ADAM17 |
| Links to the AnimalTFDB for ADAM17 |
Regulation From TransFac database | TACE(h) + Eve-1c(h) <==> TACE(h):Eve-1c(h) (binding) | TACE(h) + Eve-1d(h) <==> TACE(h):Eve-1d(h) (binding) | TACE(h) --> TACE-p100(h) + protein remnants (cleavage) | TACE(h) --> EGFR(h){pY} (increase of phosphorylation) | TACE(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | TACE(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | TACE(h) --> AKT-1(h){pS473} (increase of phosphorylation) | ADAM17(h) --> TACE(h) (expression). | ADAM17(h) --> TACE(h) (expression). | APP770(h) --TACE(h)--> sAPP770alpha(h) + APP-C83(h) (cleavage) | AR-isoform1(h) --TACE(h)--> AR-isoform1-p20(h) + protein remnants (cleavage) | AR-isoform1(h) --TACE(h)--> AR-isoform1-p17(h) + protein remnants (cleavage) | AR-isoform1(h) --TACE(h)--> AR-isoform1-p12(h) + protein remnants (cleavage) | HB-EGF(h) --TACE(h)--> HB-EGF-p17(h) + protein remnants (cleavage) | HB-EGF(h) --TACE(h)--> HB-EGF-p16(h) + protein remnants (cleavage) |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 103 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 157 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 174 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 264 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 379 | Phosphotyrosine. | Swiss-Prot 53.0 | 382 | Phosphoserine. | Swiss-Prot 53.0 | 452 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 498 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 539 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 551 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 594 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 735 | Phosphothreonine (by MAPK). | Swiss-Prot 53.0 | 791 | Phosphoserine. | Swiss-Prot 53.0 | 819 | Phosphoserine. | Swiss-Prot 53.0 | 735 | Phosphothreonine (MAPK3) | 12058067 | Phospho.ELM 6.0 | 819 | Phosphoserine (Lck) | 12621058;15743820 | Phospho.ELM 6.0 | 791 | Phosphoserine | 12621058;17081983 | Phospho.ELM 6.0 | 379 | Phosphotyrosine | 17081983 | Phospho.ELM 6.0 | 382 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 9612868 - 9614868 | Agilent_014791 |
chr2 |
Promoter: 9612868 - 9614868 | GSE27584 |
chr2 |
Promoter: 9612868 - 9614868 | Agilent_014791_44K |