| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6790 |
Name | AURKA |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for AURKA |
| Links to the AnimalTFDB for AURKA |
Regulation From TransFac database | Aurora-A(h) + RasGAP(h) <==> RasGAP(h):Aurora-A(h) (binding) | Aurora-A(h) + survivin(mo) <==> Aurora-A(h):survivin(mo) (binding) | brca1(h) + Aurora-A(h) <==> brca1(h):Aurora-A(h) (binding) | Aurora-A(h) + PP1(h) <==> Aurora-A(h):PP1(h) (binding) | Aurora-A(h) + PP1-alpha(r) <==> Aurora-A(h):PP1-alpha(r) (binding) | Aurora-A(h) + PP1-gamma1(r) <==> Aurora-A(h):PP1-gamma1(r) (binding) | Aurora-A(h) + PP1-beta(r) <==> Aurora-A(h):PP1-beta(r) (binding) | TPX2(h) + Aurora-A(h) <==> TPX2(h):Aurora-A(h) (binding) | Aurora-A(h) + AURKAIP1(h) <==> Aurora-A(h):AURKAIP1(h) (binding) | TACC1(h) + Aurora-A(h) <==> TACC1(h):Aurora-A(h) (binding) | TACC3(h) + Aurora-A(h) <==> TACC3(h):Aurora-A(h) (binding) | Ajuba(h) + Aurora-A(h) <==> Ajuba(h):Aurora-A(h) (binding) | Aurora-A(h) + Lats2(h) <==> Aurora-A(h):Lats2(h) (binding) | p53(h) + Aurora-A(h) <==> p53(h):Aurora-A(h) (binding) | Rock-1(h) + Aurora-A(h) <==> Rock-1(h):Aurora-A(h) (binding) | Rock-1(h) + Aurora-A(h) + DDX3(h) + HLR2(h) <==> Rock-1(h):Aurora-A(h):DDX3(h):HLR2(h) (binding) | Aurora-A(h) + IPP-2(h) <==> Aurora-A(h):IPP-2(h) (binding) | Aurora-A(h) + CENP-A(h) <==> Aurora-A(h):CENP-A(h) (binding) | Aurora-A(h) + CPEB1-xbb2(h) <==> Aurora-A(h):CPEB1-xbb2(h) (binding) | Aurora-A(h) + Chfr(h) <==> Aurora-A(h):Chfr(h) (binding) | Aurora-A(h) + PAK2(h) <==> Aurora-A(h):PAK2(h) (binding) | Aurora-A(h) + RASSF1-A(m.s.) <==> Aurora-A(h):RASSF1-A(m.s.) (binding) | Aurora-A(h) + rab10(h) <==> Aurora-A(h):rab10(h) (binding) | Aurora-A(h) + p16INK4a(h) <==> Aurora-A(h):p16INK4a(h) (binding) | Aurora-A(h) + SOD2(h) <==> Aurora-A(h):SOD2(h) (binding) | Aurora-A(h) + EFABP(h) <==> Aurora-A(h):EFABP(h) (binding) | Aurora-A(h) + UbcH7(h) <==> Aurora-A(h):UbcH7(h) (binding) | AURKA(h) --> Aurora-A(h) (expression). | Aurora-A(h){p} --PP1(rb)--> Aurora-A(h) + p (dephosphorylation) | DDB1(h) --/ Aurora-A(h) (decrease of abundance) | brca1(h) + ATP --Aurora-A(h)--> brca1(h){pS308} + ADP (phosphorylation) | TACC3(h) + ATP --Aurora-A(h)--> TACC3(h){p} + ADP (phosphorylation) | Hec1(h) + ATP --Aurora-A(h)--> Hec1(h){p} + ADP (phosphorylation) | Nuf2(h) + ATP --Aurora-A(h)--> Nuf2(h){p} + ADP (phosphorylation) | Ajuba(h) + ATP --Aurora-A(h)--> Ajuba(h){p} + ADP (phosphorylation) | p53(h) + ATP --Aurora-A(h)--> p53(h){pS215} + ADP (phosphorylation) | CENP-A(h) + ATP --Aurora-A(h)--> CENP-A(h){pS7} + ADP (phosphorylation) | DLG7(h) + ATP --Aurora-A(h)--> DLG7(h){p} + ADP (phosphorylation) | CPEB1-xbb2(h) + ATP --Aurora-A(h)--> CPEB1-xbb2(h){p} + ADP (phosphorylation) | RASSF1-A(m.s.) + ATP --Aurora-A(h)--> RASSF1-A(m.s.){p} + ADP (phosphorylation) | Aurora-A(h) --> DLG7(h) (stabilization) | Aurora-A(h) + p65PAK(r) <==> Aurora-A(h):p65PAK(r) (binding) | Aurora-A(h) + p65PAK(r){p} <==> Aurora-A(h):p65PAK(r){p} (binding) | Aurora-A(h) + ATP --p65PAK(r)--> Aurora-A(h){pT288}{pS342} + ADP (phosphorylation) | AURKA(h) --> Aurora-A(h) (expression). | 4 ATP + DLG7-xbb1(h) --Aurora-A(h)--> 4 ADP + DLG7-xbb1(h){pS627}{pS725}{pS757}{pS830} (phosphorylation) |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 10 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 104 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 148 | Phosphotyrosine | 16083426 | Phospho.ELM 6.0 | 16 | Phosphothreonine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 226 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 266 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 278 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 287 | Phosphothreonine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 342 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 391 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 41 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 67 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 83 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 | 98 | Phosphoserine (Aurora A) | 16083426 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr20 |
Promoter: 54400258 - 54402258 | GSE27584 |
chr20 |
Promoter: 54400258 - 54402258 | GSE27584 |
chr20 |
Promoter: 54400258 - 54402258 | GSE27584 |
chr20 |
Promoter: 54400258 - 54402258 | GSE27584 |
chr20 |
Promoter: 54400258 - 54402258 | GSE27584 |
chr20 |
Promoter: 54400258 - 54402258 | GSE27584 |