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dbEMT
dbEMT 2.0
General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

6777

Name

STAT5B

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription factors   [Top]

The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget

Links to the hTFtarget for STAT5B
Links to the AnimalTFDB for STAT5B

Regulation From TransFac database

c-Kit(h) + STAT5B(h) <==> c-Kit(h):STAT5B(h) (binding)
STAT5B(h) + ATP --c-Kit(h)--> STAT5B(h){pY} + ADP (phosphorylation)
STAT5B(h) --> CDKN1A(h) (DNA binding).
STAT5B(h) + ATP --> STAT5B(h){pY} + ADP (phosphorylation)
InsR(h){p} + STAT5B(h) <==> InsR(h){p}:STAT5B(h) (binding)
2 STAT5B(h) <==> STAT5B(h):STAT5B(h) (binding)
STAT5B(h) + ATP --Hck(h)--> STAT5B(h){pY699} + ADP (phosphorylation)
STAT5B(h) --> IL-2Ralpha(h) (DNA binding).
STAT5B(h) + POU2F1(h) <==> STAT5B(h):POU2F1(h) (binding)
STAT5B(h) --> CCND1(h) (DNA binding; transactivation).
Src(h) + STAT5B(h) <==> Src(h):STAT5B(h) (binding)
ErbB1(h) + STAT5B(h) <==> ErbB1(h):STAT5B(h) (binding)
RON(h) + STAT5B(h) <==> RON(h):STAT5B(h) (binding)
2 STAT5B(h) <==> (STAT5B(h))2 (oligomerization)
STAT5B(h) + STAT5A(h) <==> STAT5B(h):STAT5A(h) (oligomerization)
STAT5B(h) --> IRF1(h) (DNA binding).
STAT5B(h) --> PIM1(h) (DNA binding).
STAT5B(h) --> CISH(h) (DNA binding).
STAT5B(h) --> WARS2(h) (DNA binding).
STAT5B(h) + ATP --> STAT5B(h){p} + ADP (phosphorylation)
STAT5B(h) + ATP --> STAT5B(h){pY699} + ADP (phosphorylation)
STAT5B(h) --> STAT5B(h) (translocation)
STAT5B(h) --> CSN2(h) (DNA binding).
STAT5B(h) --> PRF1(h) (DNA binding).
STAT5B(h) --> FCGR1C(h) (DNA binding).
STAT5B(h) --> STAT5B(h) (expression).
STAT5B(h) --> STAT5B(h) (translocation)
STAT5B(h) --> Socs3(m) (DNA binding).
STAT5B(h) --> CSN2(b) (DNA binding; transactivation).
STAT5B(h) --> IFNG(h) (DNA binding).
STAT5B(h) --> OSM(h) (DNA binding; transactivation).
STAT5B(h) --> CISH(h) (DNA binding).
STAT5B(h) + ATP --> STAT5B(h){pY} + ADP (phosphorylation)
STAT5B(h) + 4 ATP --> STAT5B(h){pY699}{pY725}{pY740}{pY743} + 4 ADP (phosphorylation)
STAT5B(h) --> STAT5B(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

193Phosphoserine.Swiss-Prot 53.0
699Phosphotyrosine (by JAK) (By similarity).Swiss-Prot 53.0
731Phosphoserine9804779Phospho.ELM 6.0
725Phosphotyrosine (EGFR)11751923Phospho.ELM 6.0
740Phosphotyrosine (EGFR)11751923Phospho.ELM 6.0
743Phosphotyrosine (EGFR)11751923Phospho.ELM 6.0
679Phosphotyrosine (Src)12621061Phospho.ELM 6.0
699Phosphotyrosine (Tyk2;EGFR;HC)11751923;12411494;10830280Phospho.ELM 6.0
90Phosphotyrosine16497976Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr17

Promoter: 37681450 - 37683450Agilent_014791

chr17

Promoter: 37681450 - 37683450GSE27584

chr17

Promoter: 37681450 - 37683450Agilent_014791_44K


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