Entrez Gene

Basic Information
Gene ID	5747
Name	PTK2
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget
Transcription factors [Top]
Links to the hTFtarget for PTK2
Links to the AnimalTFDB for PTK2
Regulation From TransFac database
FAK1(h) + paxillin(h) <==> FAK1(h):paxillin(h) (binding)
FAK1(h) + Cas(h) <==> FAK1(h):Cas(h) (binding)
FAK1(h) + vinculin(h) <==> FAK1(h):vinculin(h) (binding)
FAK1(h) --Caspase-3(h)--> protein remnants (processing)
FAK1(h) --Caspase-7(h)--> protein remnants (processing)
FAK1(h) + NTP --Src(v.s.)--> FAK1(h){pY} + NDP (phosphorylation)
FAK1(h) + NTP --Fyn(m)--> FAK1(h){pY} + NDP (phosphorylation)
FAK1(h) + NTP --Yes(v.s.)--> FAK1(h){pY} + NDP (phosphorylation)
FAK1(h) + NTP --Pyk2(r){pY402}{pY579}{pY580}--> FAK1(h){pY} + NDP (phosphorylation)
FAK1(h) + HEF1(h) <==> FAK1(h):HEF1(h) (binding)
alpha IIb-integrin(h):beta3-integrin(h) + FAK1(h) <==> alpha IIb-integrin(h):beta3-integrin(h):FAK1(h) (binding)
FAK1(h) + ATP --> FAK1(h){pY397} + ADP (phosphorylation)
FAK1(h) + ATP --> FAK1(h){p} + ADP (phosphorylation)
Bmx(m.s.) + FAK1(h) <==> Bmx(m.s.):FAK1(h) (binding)
FAK1(h) + LMW-PTP(h) <==> FAK1(h):LMW-PTP(h) (binding)
FAK1(h) + n ubiquitin(h) --> FAK1(h){ub(n)} (ubiquitination)
FAK1(h) + ATP --> FAK1(h){pY} + ADP (phosphorylation)
FAK1(h) + 4 ATP --> FAK1(h){pY397}{pY577}{pY861}{pY925} + 4 ADP (phosphorylation)
p85(h) + FAK1(h) <==> p85(h):FAK1(h) (binding)
FAK1(h) + SOCS-2(h) <==> FAK1(h):SOCS-2(h) (binding)
FAK1(h) + APG12(h) <==> FAK1(h):APG12(h) (binding)
FAK1(h) + ATP --> FAK1(h){pY576} + ADP (phosphorylation)
ErbB2(m.s.) + FAK1(h) <==> ErbB2(m.s.):FAK1(h) (binding)
FAK1(h) + beta1-integrin(h) <==> FAK1(h):beta1-integrin(h) (binding)
FAK1(h) + 2 ATP --> FAK1(h){pY861}{pY925} + 2 ADP (phosphorylation)
FAK1(h) + ATP --> FAK1(h){pY861} + ADP (phosphorylation)
PTK2(h) --> FAK1(h) (expression).
FAK1(h){pY} --LMW-PTP(h)--> FAK1(h) + p (dephosphorylation)
p53(m.s.) --/ FAK1(h) (decrease of abundance)
Cas(mo) + ATP --FAK1(h)--> Cas(mo){pY} + ADP (phosphorylation)
PTK2(h) --> FAK1-Isoform-1(h) (expression).
PTK2(h) --> FAK1-isoform-2(h) (expression).
PTK2(h) --> FAK1-isoform-3(h) (expression).
PTK2(h) --> FAK1-isoform-4(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
397	Phosphotyrosine.		Swiss-Prot 53.0
407	Phosphotyrosine.		Swiss-Prot 53.0
576	Phosphotyrosine (by autocatalysis).		Swiss-Prot 53.0
577	Phosphotyrosine (by autocatalysis).		Swiss-Prot 53.0
722	Phosphoserine.		Swiss-Prot 53.0
840	Phosphoserine.		Swiss-Prot 53.0
843	Phosphoserine.		Swiss-Prot 53.0
861	Phosphotyrosine.		Swiss-Prot 53.0
910	Phosphoserine.		Swiss-Prot 53.0
925	Phosphotyrosine.		Swiss-Prot 53.0
407	Phosphotyrosine (ROCK1)	7529876;16254240;15247219;12960434	Phospho.ELM 6.0
397	Phosphotyrosine (FAK)	7509446	Phospho.ELM 6.0
861	Phosphotyrosine (Src)	8941336;11927607	Phospho.ELM 6.0
577	Phosphotyrosine (FAK)	7529876	Phospho.ELM 6.0
925	Phosphotyrosine	12370821;7997267	Phospho.ELM 6.0
576	Phosphotyrosine (FAK)	7529876	Phospho.ELM 6.0
843	Phosphoserine	11160818	Phospho.ELM 6.0
910	Phosphoserine	11160818	Phospho.ELM 6.0
840	Phosphoserine	11160818;17081983	Phospho.ELM 6.0
722	Phosphoserine	11160818	Phospho.ELM 6.0
347	Phosphotyrosine	12515828	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr8	Promoter: 142080014 - 142082014	Agilent_014791
chr8	Promoter: 142080014 - 142082014	GoldenGate_Methylation_Cancer_Panel_I
chr8	Promoter: 142080014 - 142082014	GoldenGate_Methylation_Cancer_Panel_I
chr8	Promoter: 142080014 - 142082014	GSE27584
chr8	Promoter: 142080014 - 142082014	GSE27584
chr8	Promoter: 142080014 - 142082014	Agilent_014791_44K

Transcription factors [Top]

Post Translational Modification [Top]

Methylation Profile [Top]