| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4792 |
Name | NFKBIA |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for NFKBIA |
| Links to the AnimalTFDB for NFKBIA |
Regulation From TransFac database | IkappaB-alpha(h) + Ubc9(h){sumo} + ATP --> IkappaB-alpha(h){sumo} + Ubc9(h) + AMP + p (conjugation; stabilization) | IkappaB-alpha(h) + ATP --IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + ATP --IKK-alpha(h)--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + NF-kappaB(m) <==> IkappaB-alpha(h):NF-kappaB(m) (binding) | IkappaB-alpha(h) + ATP --IKK-alpha(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + ATP --IKK-beta(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation) | RelA-p65(m) + IkappaB-alpha(h) <==> RelA-p65(m):IkappaB-alpha(h) (binding). | v-Rel(REVT) + IkappaB-alpha(h) <==> v-Rel(REVT):IkappaB-alpha(h) (binding). | NF-kappaB1(h) + IkappaB-alpha(h) <==> NF-kappaB1(h):IkappaB-alpha(h) (binding). | NF-kappaB1-isoform1(m) + IkappaB-alpha(h) <==> NF-kappaB1-isoform1(m):IkappaB-alpha(h) (binding). | IkappaB-alpha(h) + Raf-1(m) <==> IkappaB-alpha(h):Raf-1(m) (binding) | NF-kappaB(r) + IkappaB-alpha(h) <==> NF-kappaB(r):IkappaB-alpha(h) (binding). | NF-kappaB(h) + IkappaB-alpha(h) <==> NF-kappaB(h):IkappaB-alpha(h) (binding). | IkappaB-alpha(h) + ATP --CSN(h)--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IKK-beta(h) + IkappaB-alpha(h) <==> IKK-beta(h):IkappaB-alpha(h) (binding) | IkappaB-alpha(h) + ATP --IKK-beta(h)--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + ATP --IKK-i(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + ATP --IKK-i(h)--> IkappaB-alpha(h){pS36} + ADP (phosphorylation) | IkappaB-alpha(h) + ATP --IKK-i(h){pS172}--> IkappaB-alpha(h){pS36} + ADP (phosphorylation) | IkappaB-alpha(h) + NTP --TBK1(h)--> IkappaB-alpha(h){pS36} + NDP (phosphorylation) | IkappaB-alpha(h) + NTP --IKK-beta(v.s.)--> IkappaB-alpha(h){pS32} + NDP (phosphorylation) | IkappaB-alpha(h) + ATP --PKR(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + NF-kappaB1-p50(h) <==> IkappaB-alpha(h):NF-kappaB1-p50(h) (binding) | RelA-p65(h) + IkappaB-alpha(h) <==> RelA-p65(h):IkappaB-alpha(h) (binding) | IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){pS32} + ADP (phosphorylation) | IkappaB-alpha(h) + RelA-p65(h) <==> IkappaB-alpha(h):RelA-p65(h) (binding) | RelA-p65(h) + c-Rel(h) + IkappaB-alpha(h) <==> IkappaB-alpha(h):RelA-p65(h):c-Rel(h) (binding) | IkappaB-alpha(h) --> protein remnants (degradation) | IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){pY} + ADP (phosphorylation) | IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) | IkappaB-alpha(h) + 2 ATP --> IkappaB-alpha(h){pS32}{pS36} + 2 ADP (phosphorylation) | IkappaB-alpha(h) + RelA-p65(h){pS468}{pS536} <==> IkappaB-alpha(h):RelA-p65(h){pS468}{pS536} (binding) | HDAC1(h) + IkappaB-alpha(h) <==> HDAC1(h):IkappaB-alpha(h) (binding) | HDAC3(h) + IkappaB-alpha(h) <==> HDAC3(h):IkappaB-alpha(h) (binding) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) | IkappaB-alpha(h) + NF-kappaB1(h) + RelA-p65(h) + rps3(h) <==> IkappaB-alpha(h):NF-kappaB1(h):RelA-p65(h):rps3(h) (binding) | IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){pS} + ADP (phosphorylation) | IkappaB-alpha(h) + POM121(h) <==> IkappaB-alpha(h):POM121(h) (binding) | IkappaB-alpha(h) + n ubiquitin(h) --> IkappaB-alpha(h){ub{K48}(n)} (ubiquitination) | Trx1(h) --> IkappaB-alpha(h) (activation) | NFKBIA(h) --> IkappaB-alpha(h) (expression). | IL-1beta(h) --/ IkappaB-alpha(h) (decrease of abundance) | TNF-alpha(h) --/ IkappaB-alpha(h) (decrease of abundance) | TNF-alpha(m.s.) --/ IkappaB-alpha(h) (decrease of abundance) | RelA-p65(m.s.) --> IkappaB-alpha(h) (increase of abundance) | HCV-NS3-1A(HCV1A):HCV-NS4A-1A(HCV1A) --> IkappaB-alpha(h) (increase of abundance) | IL-1(h) --> IkappaB-alpha(h) (increase of cleavage) | TNF-alpha(h) --> IkappaB-alpha(h) (increase of cleavage) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) | IFNalpha(m) --> IkappaB-alpha(h) (increase of abundance) | IFNbeta(m) --> IkappaB-alpha(h) (increase of abundance) | TNF(h) --/ IkappaB-alpha(h) (decrease of abundance) | LIGHT(h) --/ IkappaB-alpha(h) (decrease of abundance) | LT-betaR(h) --/ IkappaB-alpha(h) (decrease of abundance) | TRAM(h) --> IkappaB-alpha(h) (increase of abundance) | IL-17A(h) --/ IkappaB-alpha(h) (decrease of abundance) | H2O2 --/ IkappaB-alpha(h) (decrease of abundance) | LPS --/ IkappaB-alpha(h) (decrease of abundance) | Jagged1(h) --/ IkappaB-alpha(h) (decrease of abundance) | CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2:RelA-p65(h) + ATP --> CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2 + RelA-p65(h){pS529} + ADP (phosphorylation; dissociation) | IkappaB-alpha(h) --/ SELE(h) (transrepression) | LRF(h) + IkappaB-alpha(h) <==> LRF(h):IkappaB-alpha(h) (binding) | IkappaB-alpha(h) --calpain(h)--> protein remnants (degradation) | IkappaB-alpha(h) + ATP --IKK-beta(m)--> IkappaB-alpha(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + HDAC1(m.s.) <==> IkappaB-alpha(h):HDAC1(m.s.) (binding) | RelA-p65(h) + IkappaB-alpha(h) <==> RelA-p65(h):IkappaB-alpha(h) (binding) | IkappaB-alpha(h) + RelA-p65(h) + NF-kappaB1-p50(h) <==> IkappaB-alpha(h):RelA-p65(h):NF-kappaB1-p50(h) (binding) | IkappaB-alpha(h) + HDAC3(m.s.) <==> HDAC3(m.s.):IkappaB-alpha(h) (binding) | IkappaB-alpha(h) --> protein remnants (degradation) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) | BARD1(h) + IkappaB-alpha(h) <==> BARD1(h):IkappaB-alpha(h) (binding) | Pirin(h) + IkappaB-alpha(h) <==> Pirin(h):IkappaB-alpha(h) (binding) | IkappaB-alpha(h) + ATP --IKK(h)--> IkappaB-alpha(h){pS32} + ADP (phosphorylation) | IkappaB-alpha(h) --/ Beclin-1(h) (decrease of abundance) | NFKBIA(h) --> IkappaB-alpha(h) (expression). | HCV-NS5A-1B-Japanese(HCV1BJapan) --> IkappaB-alpha(h) (increase of cleavage) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) | IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation) |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 32 | Phosphoserine (by IKKA and IKKE). | Swiss-Prot 53.0 | 36 | Phosphoserine (by IKKA, IKKB and IKKE). | Swiss-Prot 53.0 | 42 | Phosphotyrosine (by Tyr-kinases). | Swiss-Prot 53.0 | 21 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin)(Potential). | Swiss-Prot 53.0 | 22 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin)(Potential). | Swiss-Prot 53.0 | 42 | Phosphotyrosine (Lck;Src) | 8797825;12432072;9792645 | Phospho.ELM 6.0 | 305 | Phosphotyrosine (Abl) | 14757045 | Phospho.ELM 6.0 | 288 | Phosphoserine (CK2 alpha) | 8622692 | Phospho.ELM 6.0 | 293 | Phosphoserine (CK2 alpha) | 12167702 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr14 |
Promoter: 34943195 - 34945195 | Agilent_014791 |
chr14 |
Promoter: 34943195 - 34945195 | GSE27584 |
chr14 |
Promoter: 34943195 - 34945195 | Agilent_014791_44K |