| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3718 |
Name | JAK3 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for JAK3 |
| Links to the AnimalTFDB for JAK3 |
Regulation From TransFac database | Jak3(h) + ATP --> Jak3(h){pY} + ADP (phosphorylation) | Jak3(h) + STAM(h) <==> Jak3(h):STAM(h) (binding) | gamma-c(h) + Jak3(h) <==> gamma-c(h):Jak3(h) (binding) | Jak3(h) + SOCS-1(m) <==> Jak3(h):SOCS-1(m) (binding) | SOCS-3(h) + Jak3(h) <==> SOCS-3(h):Jak3(h) (binding) | ErbB2(h){pY1221}{pY1222} + Jak3(h) <==> ErbB2(h){pY1221}{pY1222}:Jak3(h) (binding) | ErbB3-isoform1(h){pY1276} + Jak3(h) <==> ErbB3-isoform1(h){pY1276}:Jak3(h) (binding) | Jak3(h) + VIL(h) <==> Jak3(h):VIL(h) (binding) | Jak3(h) --> stromelysin1(h) (increase of abundance) | IL-17A(h) --> Jak3(h) (activation; phosphorylation) | JAK3(h) --> Jak3(h) (expression). | Jak3(h){pY} --CD45(h)--> Jak3(h) + p (dephosphorylation) | JAK3(h) --> Jak3-isoform2(h) (expression). | JAK3(h) --> Jak3-isoform1(h) (expression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 785 | Phosphotyrosine. | Swiss-Prot 53.0 | 980 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 980 | Phosphotyrosine (JAK3) | 9391116 | Phospho.ELM 6.0 | 981 | Phosphotyrosine (JAK3) | 9391116 | Phospho.ELM 6.0 | 785 | Phosphotyrosine (JAK3) | 15592455;15121872 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr19 |
Promoter: 17819300 - 17821300 | Agilent_014791 |
chr19 |
Promoter: 17819300 - 17821300 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 17819300 - 17821300 | GSE27584 |
chr19 |
Promoter: 17819300 - 17821300 | Agilent_014791_44K |