| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2034 |
Name | EPAS1 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for EPAS1 |
| Links to the AnimalTFDB for EPAS1 |
Regulation From TransFac database | HIF2A(h) + arnt(h) <==> HIF2A(h):arnt(h) (binding). | HIF2A(h) + CBP(v.s.) <==> HIF2A(h):CBP(v.s.) (binding) | HIF2A(h) + VHL(h) <==> HIF2A(h):VHL(h) (binding) | HIF2A(h) + VHL(h):elongin B(h):elongin C(h) <==> HIF2A(h):VHL(h):elongin B(h):elongin C(h) (binding) | HIF2A(h) + n ubiquitin(h) --VHL(h)--> HIF2A(h){ub(n)} (ubiquitination) | bbs1(h) + HIF2A(h) <==> bbs1(h):HIF2A(h) (binding) | bbs2(h) + HIF2A(h) <==> bbs2(h):HIF2A(h) (binding) | bbs4(h) + HIF2A(h) <==> bbs4(h):HIF2A(h) (binding) | HIF2A(h) --> CXCL12(h) (transactivation) | EPAS1(h) --> HIF2A(h) (expression). | ATF-3(h) --> HIF2A(h) (activation; increase of abundance) | JAB1(h) --> HIF2A(h) (increase of abundance) | COPS2(h) --> HIF2A(h) (increase of abundance) | HIF2A(h) --> MIRN210(h) (DNA binding). | EPAS1(h) --> HIF2A(h) (expression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 405 | 4-hydroxyproline (By similarity). | Swiss-Prot 53.0 | 531 | 4-hydroxyproline (By similarity). | Swiss-Prot 53.0 | 840 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 847 | 3-hydroxyasparagine (By similarity). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 46376567 - 46378567 | Agilent_014791 |
chr2 |
Promoter: 46376567 - 46378567 | GSE27584 |
chr2 |
Promoter: 46376567 - 46378567 | Agilent_014791_44K |