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dbEMT
dbEMT 2.0
General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

2002

Name

ELK1

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription factors   [Top]

The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget

Links to the hTFtarget for ELK1
Links to the AnimalTFDB for ELK1

Regulation From TransFac database

Elk-1(h) + ATP --p38beta2(h){p}--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) + ATP --p38gamma(r){p}--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) + ATP --p38alpha(m){p}--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) --> Egr2(m) (DNA binding).
Elk-1(h) --> Py(PA) (DNA binding).
Elk-1(h) --> FOS(x) (DNA binding).
SRF(h) + Elk-1(h) <==> SRF(h):Elk-1(h) (binding; assembly; interaction)
SRF(c) + Elk-1(h) <==> SRF(c):Elk-1(h) (binding).
SRF(fc) + Elk-1(h) <==> SRF(fc):Elk-1(h) (binding).
SRF-L(m) + Elk-1(h) <==> SRF-L(m):Elk-1(h) (binding).
SRF(r) + Elk-1(h) <==> SRF(r):Elk-1(h) (binding).
SRF(x) + Elk-1(h) <==> SRF(x):Elk-1(h) (binding).
Elk-1(h) + ATP --p38delta(h)--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) --> Egr2(h) (DNA binding; transactivation).
Elk-1(h) --> SOD1(r) (DNA binding).
Elk-1(h) + C/EBPbeta(LAP)(r) <==> Elk-1(h):C/EBPbeta(LAP)(r) (binding; interaction) [re.
C/EBPbeta(p20)(r) + Elk-1(h) <==> Elk-1(h):C/EBPbeta(p20)(r) (binding; interaction) [re.
Elk-1(h) --> IE-1(HCMV) (DNA binding; transactivation).
Elk-1(h) --> MIE(SCMVAGM) (DNA binding; transactivation).
Elk-1(h) --> SRF(h) (DNA binding).
Elk-1(h) + ATP --ERK1(h)--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) --> FOS(h) (DNA binding).
Elk-1(h) + ATP --ERK2(h)--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) --> KCNK5(h) (DNA binding).
Elk-1(h) --> PSEN1(h) (DNA binding).
Elk-1(h) + ATP --ERK2(m)--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) + ATP --> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) --> BMP2(h) (transactivation)
Elk-1(h) --> SPP1(h) (transactivation)
Elk-1(h) --> TLR9(h) (DNA binding).
Elk-1(h) --> EGR1(h) (DNA binding).
Elk-1(h) --> SULT1A1(h) (DNA binding).
Elk-1(h) --> SULT1A3(h) (DNA binding).
Elk-1(h) --> PYGO2(h) (DNA binding).
Elk-1(h) + ATP --ERK(m.s.)--> Elk-1(h){p} + ADP (phosphorylation)
Elk-1(h) + ATP --> Elk-1(h){pS383} + ADP (phosphorylation)
Elk-1(h) --> PRKCA(h) (DNA binding).
brca1(m.s.) + Elk-1(h) <==> brca1(m.s.):Elk-1(h) (binding)
Elk-1(h) + brca1(h) <==> Elk-1(h):brca1(h) (binding)
Elk-1(h) --> INSIG2(h) (DNA binding).
Elk-1(h) --> Vil1(m) (DNA binding; transactivation).
ELK1(h) --> Elk-1(h) (expression).
Elk1-isoform1(h) --> ACTB(h) (DNA binding).
Elk1-isoform1(h) --> FOS(h) (DNA binding; transactivation).
Elk1-isoform1(h) --> MSV(MSV) (DNA binding).
Elk1-isoform1(h) --> TNF(h) (DNA binding; transactivation).
Elk1-isoform1(h) --> ELK1(h) (DNA binding).
Elk1-isoform1(h) --> NOS3(h) (DNA binding; transactivation).
Elk1-isoform1(h) --> Nr4a1(m) (DNA binding; transactivation).
Elk1-isoform1(h) --> SRF(m) (DNA binding).
Id3(m.s.) + Elk1-isoform1(h) <==> Id3(m.s.):Elk1-isoform1(h) (binding)
Elk1-isoform1(h) + sin3a(m.s.) <==> Elk1-isoform1(h):sin3a(m.s.) (binding)
Elk1-isoform1(h) + HDAC1(m.s.) <==> Elk1-isoform1(h):HDAC1(m.s.) (binding)
Elk1-isoform1(h) + ATP --> Elk1-isoform1(h){pS383} + ADP (phosphorylation)
CBP(m) + Elk1-isoform1(h) <==> CBP(m):Elk1-isoform1(h) (binding)
Elk1-isoform1(h) + Ubc9(m.s.) <==> Elk1-isoform1(h):Ubc9(m.s.) (binding)
Elk1-isoform1(h) + 3 sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(m.s.)--> Elk1-isoform1(h){sumoK230}{sumoK249}{sumoK254} (sumoylation)
Elk1-isoform1(h) + SUMO2(m.s.) --Aos1(h):SAE2(h),Ubc9(m.s.)--> Elk1-isoform1(h){sumo2} (sumoylation)
Elk1-isoform1(h) + sumo3(m.s.) --Aos1(h):SAE2(h),Ubc9(m.s.)--> Elk1-isoform1(h){sumo3} (sumoylation)
Elk1-isoform1(h) + sumo1(m.s.) --> Elk1-isoform1(h){sumo} (sumoylation)
Elk1-isoform1(h) + 3 SUMO2(m.s.) --> Elk1-isoform1(h){sumo2K230}{sumo2K249}{sumo2K254} (sumoylation)
Elk1-isoform1(h) + sumo3(m.s.) --> Elk1-isoform1(h){sumo3} (sumoylation)
Elk1-isoform1(h) + ATP --ERK1(h)--> Elk1-isoform1(h){pS383} + ADP (phosphorylation)
Elk1-isoform1(h) + ATP --ERK2(h)--> Elk1-isoform1(h){pS383} + ADP (phosphorylation)
ELK1(h) --> Elk1-isoform1(h) (expression).
ELK1(h) --> Elk1-isoform2(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

324Phosphoserine (by MAPK1).Swiss-Prot 53.0
336Phosphothreonine (by MAPK1).Swiss-Prot 53.0
383Phosphoserine (by MAPK1).Swiss-Prot 53.0
389Phosphoserine (by MAPK1).Swiss-Prot 53.0
422Phosphoserine (by MAPK1).Swiss-Prot 53.0
230Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
249Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
254Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
383Phosphoserine (MAPK14;MAPK3)9130707;8548291;8262053;11145955;11309409;8887554Phospho.ELM 6.0
389Phosphoserine (MAPK14;MAPK3)9130707;8548291;8262053;11145955Phospho.ELM 6.0
417Phosphothreonine (PRP4)10799319Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chrX

Promoter: 47394464 - 47396464Agilent_014791

chrX

Promoter: 47394464 - 47396464GoldenGate_Methylation_Cancer_Panel_I

chrX

Promoter: 47394464 - 47396464GSE27584

chrX

Promoter: 47394464 - 47396464Agilent_014791_44K


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