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dbEMT
dbEMT 2.0
General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

1399

Name

CRKL

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription factors   [Top]

The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget

Links to the hTFtarget for CRKL
Links to the AnimalTFDB for CRKL

Regulation From TransFac database

CrkL(h) + ATP --> CrkL(h){pY} + ADP (phosphorylation)
EpoR(m){pY} + CrkL(h) <==> EpoR(m){pY}:CrkL(h) (binding)
CrkL(h) + ATP --Lyn(m)--> CrkL(h){pY} + ADP (phosphorylation)
CrkL(h) + Sos1(m) <==> CrkL(h):Sos1(m) (binding)
CrkL(h) + C3G(h) <==> CrkL(h):C3G(h) (binding)
CrkL(h) + SHIP-145(m){pY} + c-Cbl(m){pY} + EpoR(m){pY} + SHP-2(m){pY} + Shc-1(m){pY} <==> CrkL(h):SHIP-145(m){pY}:c-Cbl(m){pY}:EpoR(m){pY}:SHP-2(m){pY}:Shc-1(m){pY} (binding)
EPHB6(h) + CrkL(h) <==> EPHB6(h):CrkL(h) (binding)
C3G(m.s.) + CrkL(h) <==> C3G(m.s.):CrkL(h) (binding)
CrkL(h) + c-Cbl(h){pY} <==> CrkL(h):c-Cbl(h){pY} (binding)
STAT5(h) + CrkL(h) <==> STAT5(h):CrkL(h) (binding)
c-Cbl(h) + CrkL(h) <==> c-Cbl(h):CrkL(h) (binding)
CrkL(h) + WASP(h){pY} <==> CrkL(h):WASP(h){pY} (binding)
CrkL(h) + Syk(h){pY} <==> CrkL(h):Syk(h){pY} (binding)
Gab-1(h) + CrkL(h) <==> Gab-1(h):CrkL(h) (binding)
CrkL(h) + Gab-1(m) <==> CrkL(h):Gab-1(m) (binding)
CrkL(h) + Grb-2(h) <==> CrkL(h):Grb-2(h) (binding)
CrkL(h) + HEF1(h){pY} <==> CrkL(h):HEF1(h){pY} (binding)
Abl(h) + CrkL(h) <==> Abl(h):CrkL(h) (binding)
Sos(h) + CrkL(h) <==> Sos(h):CrkL(h) (binding)
Cas(h) + CrkL(h) <==> Cas(h):CrkL(h) (binding)
Sos1(h) + CrkL(h) <==> Sos1(h):CrkL(h) (binding)
Sos2(h) + CrkL(h) <==> Sos2(h):CrkL(h) (binding)
HEF1(h) + CrkL(h) <==> HEF1(h):CrkL(h) (binding)
ARMS(m.s.){pY} + CrkL(h) <==> ARMS(m.s.){pY}:CrkL(h) (binding)
C3G(h) + CrkL(h) + ARMS(m.s.){pY} <==> C3G(h):CrkL(h):ARMS(m.s.){pY} (binding)
CrkL(h) + ARMS(r) <==> CrkL(h):ARMS(r) (binding)
CrkL(h) + c-Cbl(h){pY}2 <==> CrkL(h):c-Cbl(h){pY}2 (binding)
c-Cbl(h) + CrkL(h) + Grb-2(h) <==> c-Cbl(h):CrkL(h):Grb-2(h) (binding)
CrkL(h) + FcgammaRI alpha(h) <==> CrkL(h):FcgammaRI alpha(h) (binding)
CrkL(h) + n ATP --> CrkL(h){pY}n + n ADP (phosphorylation)
CrkL(h) + p85(h) + c-Cbl(h){pY} <==> CrkL(h):p85(h):c-Cbl(h){pY} (binding)
Crkl(h) --> CrkL(h) (expression).
C3G(m.s.) --> CrkL(h) (activation)
R-Ras(m.s.) --> CrkL(h) (activation)
WASP(h) + CrkL(h) <==> WASP(h):CrkL(h) (binding)
Syk(h) + CrkL(h) <==> Syk(h):CrkL(h) (binding)
STAT5(h) + CrkL(h) <==> STAT5(h):CrkL(h) (binding)
Gab-1(h) + CrkL(h) <==> Gab-1(h):CrkL(h) (binding)
ErbB1-p170(h){pY1125} + CrkL(h) <==> CrkL(h):ErbB1-p170(h){pY1125} (binding)
ErbB2(h){pY1222} + CrkL(h) <==> ErbB2(h){pY1222}:CrkL(h) (binding)
ErbB3-isoform1(h){pY868}{pY1276}{pY1289} + CrkL(h) <==> ErbB3-isoform1(h){pY868}{pY1276}{pY1289}:CrkL(h) (binding)
ErbB4(h){pY1162} + CrkL(h) <==> ErbB4(h){pY1162}:CrkL(h) (binding)
Crkl(h) --> CrkL(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

107Phosphoserine (By similarity).Swiss-Prot 53.0
207Phosphotyrosine.Swiss-Prot 53.0
251Phosphotyrosine.Swiss-Prot 53.0
207Phosphotyrosine (Abl)9710592Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr22

Promoter: 19600214 - 19602214Agilent_014791

chr22

Promoter: 19600214 - 19602214GSE27584


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