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dbEMT
dbEMT 2.0
General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

1398

Name

CRK

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription factors   [Top]

The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget

Links to the hTFtarget for CRK
Links to the AnimalTFDB for CRK

Regulation From TransFac database

crkII(h) + p56Dok-2(m) <==> crkII(h):p56Dok-2(m) (binding)
IRS-1(m) + crkII(h) <==> IRS-1(m):crkII(h) (binding)
IRS-1(h) + crkII(h) <==> IRS-1(h):crkII(h) (binding)
IRS-2(h) + crkII(h) <==> IRS-2(h):crkII(h) (binding)
ErbB2(r){pY1227} + crkII(h) <==> ErbB2(r){pY1227}:crkII(h) (binding)
crkII(h) + ATP --ARG(m.s.)--> crkII(h){pY221} + ADP (phosphorylation)
crkII(h) + ATP --> crkII(h){pY} + ADP (phosphorylation)
Cas(h) + crkII(h) <==> Cas(h):crkII(h) (binding)
crkII(h) + c-Cbl(h) <==> crkII(h):c-Cbl(h) (binding)
crkII(h) + C3G(h) <==> crkII(h):C3G(h) (binding)
crkII(h) + c-Cbl(h){pY} <==> crkII(h):c-Cbl(h){pY} (binding)
crkII(h) + ATP --ErbB1-p170(h)--> crkII(h){pY221} + ADP (phosphorylation)
p85(h) + crkII(h) <==> p85(h):crkII(h) (binding)
crkII(h) + p85(m.s.) <==> crkII(h):p85(m.s.) (binding)
CRK(h) --> crkII(h) (expression).
crk(h) + Src(h) + Cas(h) + EGFR(h) + CD51(h):beta3-integrin(h) <==> crk(h):Src(h):Cas(h):EGFR(h):CD51(h):beta3-integrin(h) (binding)
EPHB6(h) + crk(h) <==> EPHB6(h):crk(h) (binding)
crk(h) + Vav(h) <==> crk(h):Vav(h) (binding)
crk(h) + c-Cbl(h) <==> crk(h):c-Cbl(h) (binding)
crk(h) + C3G(h) <==> crk(h):C3G(h) (binding)
crk(h) + Rap1A(h) <==> crk(h):Rap1A(h) (binding)
crk(h) + HEF1(h) <==> crk(h):HEF1(h) (binding)
crk(h) + HEF1(h){pY} <==> crk(h):HEF1(h){pY} (binding)
Sos1(h) + crk(h) <==> Sos1(h):crk(h) (binding)
Sos2(h) + crk(h) <==> Sos2(h):crk(h) (binding)
crk(h) --> crk(h) (translocation)
crk(h) + c-Cbl(h){pY} <==> crk(h):c-Cbl(h){pY} (binding)
crk(h) + C3G-L(h) <==> crk(h):C3G-L(h) (binding)
crk(h) + ErbB1-p170(h){pY1016}{pY1125} <==> crk(h):ErbB1-p170(h){pY1016}{pY1125} (binding)
ErbB3-isoform1(h){pY1276}{pY1289} + crk(h) <==> ErbB3-isoform1(h){pY1276}{pY1289}:crk(h) (binding)
ErbB4(h){pY1162} + crk(h) <==> ErbB4(h){pY1162}:crk(h) (binding)
Bub1(h) + crk(h) <==> Bub1(h):crk(h) (binding)
crk(h) + PLSCR1(h) <==> crk(h):PLSCR1(h) (binding)
crk(h) + S10b(h) <==> crk(h):S10b(h) (binding)
crk(h) + dppa4(h) <==> crk(h):dppa4(h) (binding)
ptprh-isoform1(h) + crk(h) <==> ptprh-isoform1(h):crk(h) (binding)
crk(h) + ATP --> crk(h){pY221} + ADP (phosphorylation)
CRK(h) --> crk(h) (expression).
Dab1(m.s.) --> crk(h) (regulation of protein activity)
crk(h) --> crk(h) (translocation)
crk-I(h) + c-Cbl(h){pY} <==> crk-I(h):c-Cbl(h){pY} (binding)
C3G(h) + crk-I(h) <==> C3G(h):crk-I(h) (binding)
crk-I(h) + Shc-1(r){pY} <==> crk-I(h):Shc-1(r){pY} (binding)
CRK(h) --> crk-I(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

41Phosphoserine (By similarity).Swiss-Prot 53.0
42Phosphothreonine (By similarity).Swiss-Prot 53.0
221Phosphotyrosine.Swiss-Prot 53.0
239Phosphotyrosine.Swiss-Prot 53.0
221Phosphotyrosine (Abl;EGFR;IGF)12198159;9642287;9480991Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr17

Promoter: 1305794 - 1307794Agilent_014791

chr17

Promoter: 1305794 - 1307794GoldenGate_Methylation_Cancer_Panel_I

chr17

Promoter: 1305794 - 1307794GoldenGate_Methylation_Cancer_Panel_I

chr17

Promoter: 1305794 - 1307794GSE27584

chr17

Promoter: 1305794 - 1307794GSE27584

chr17

Promoter: 1305794 - 1307794Agilent_014791_44K


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