Entrez Gene

Basic Information
Gene ID	9518
Name	GDF15

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.420G>T; p.P140P; 19:18388428-18388428	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.693G>A; p.S231S; 19:18388701-18388701	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.37C>T; p.Q13*; 19:18386226-18386226	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.56T>A; p.L19Q; 19:18386245-18386245	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.56T>A; p.L19Q; 19:18386245-18386245	urinary_tract; bladder	carcinoma	Substitution - Missense
c.356G>A; p.R119H; 19:18388364-18388364	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.495G>A; p.Q165Q; 19:18388503-18388503	stomach	adenocarcinoma	Substitution - coding silent
c.329T>A; p.L110H; 19:18388337-18388337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.250C>T; p.P84S; 19:18386439-18386439	skin	malignant_melanoma	Substitution - Missense
c.604C>G; p.H202D; 19:18388612-18388612	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.604C>G; p.H202D; 19:18388612-18388612	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.604C>G; p.H202D; 19:18388612-18388612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.395C>G; p.S132*; 19:18388403-18388403	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.724G>A; p.G242S; 19:18388732-18388732	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.534C>T; p.P178P; 19:18388542-18388542	skin	malignant_melanoma	Substitution - coding silent
c.279G>A; p.V93V; 19:18388287-18388287	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.323_334del12; p.A108_P111delAALP; 19:18388331-18388342	kidney	carcinoma; renal_cell_carcinoma	Deletion - In frame
c.333C>T; p.P111P; 19:18388341-18388341	breast	carcinoma	Substitution - coding silent
c.333C>T; p.P111P; 19:18388341-18388341	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.530G>A; p.R177Q; 19:18388538-18388538	skin	malignant_melanoma	Substitution - Missense
c.756C>A; p.N252K; 19:18388764-18388764	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.363C>T; p.H121H; 19:18388371-18388371	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.25G>C; p.V9L; 19:18386214-18386214	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.25G>C; p.V9L; 19:18386214-18386214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.25G>C; p.V9L; 19:18386214-18386214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.104C>T; p.A35V; 19:18386293-18386293	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.758T>C; p.M253T; 19:18388766-18388766	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.163G>A; p.E55K; 19:18386352-18386352	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.65C>A; p.S22*; 19:18386254-18386254	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.408C>T; p.D136D; 19:18388416-18388416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.631T>G; p.C211G; 19:18388639-18388639	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.583G>A; p.A195T; 19:18388591-18388591	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.97G>T; p.A33S; 19:18386286-18386286	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.846G>A; p.M282I; 19:18388854-18388854	eye; uveal_tract	malignant_melanoma; spindle	Substitution - Missense
c.7G>T; p.G3W; 19:18386196-18386196	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.269C>T; p.T90M; 19:18386458-18386458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.342C>G; p.L114L; 19:18388350-18388350	thyroid	other; neoplasm	Substitution - coding silent
c.183G>A; p.E61E; 19:18386372-18386372	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.839A>G; p.N280S; 19:18388847-18388847	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.83_84insGG; p.L30fs*36; 19:18386272-18386273	lung	carcinoma	Insertion - Frameshift
c.562G>A; p.A188T; 19:18388570-18388570	skin	malignant_melanoma	Substitution - Missense
c.926G>C; p.*309S; 19:18388934-18388934	urinary_tract; bladder	carcinoma	Nonstop extension
c.138G>A; p.L46L; 19:18386327-18386327	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.138G>A; p.L46L; 19:18386327-18386327	thyroid	other; neoplasm	Substitution - coding silent
c.195C>A; p.T65T; 19:18386384-18386384	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.492_493insTCG; p.S164_Q165insS; 19:18388500-18388501	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Insertion - In frame
c.93T>C; p.S31S; 19:18386282-18386282	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.93T>C; p.S31S; 19:18386282-18386282	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.878C>T; p.S293L; 19:18388886-18388886	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.142T>A; p.S48T; 19:18386331-18386331	skin	malignant_melanoma	Substitution - Missense
c.572G>A; p.G191E; 19:18388580-18388580	skin	malignant_melanoma	Substitution - Missense
c.654G>T; p.A218A; 19:18388662-18388662	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.581G>A; p.R194K; 19:18388589-18388589	skin	malignant_melanoma	Substitution - Missense
c.718T>G; p.C240G; 19:18388726-18388726	prostate	carcinoma	Substitution - Missense
c.85G>A; p.A29T; 19:18386274-18386274	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.334G>A; p.E112K; 19:18388342-18388342	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.414A>C; p.T138T; 19:18388422-18388422	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.16C>A; p.L6I; 19:18386205-18386205	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.573G>A; p.G191G; 19:18388581-18388581	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.467A>C; p.H156P; 19:18388475-18388475	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5C>A; p.P2H; 19:18386194-18386194	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.37C>G; p.Q13E; 19:18386226-18386226	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>T; p.R37C; 19:18386298-18386298	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.865G>A; p.D289N; 19:18388873-18388873	prostate	carcinoma	Substitution - Missense
c.798C>T; p.P266P; 19:18388806-18388806	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.92C>A; p.S31Y; 19:18386281-18386281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.339G>C; p.G113G; 19:18388347-18388347	lung	carcinoma; adenocarcinoma	Substitution - coding silent

The somatic mutations from COSMIC database