Entrez Gene

Basic Information
Gene ID	8850
Name	KAT2B

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1676G>A; p.C559Y; 3:20127476-20127476	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1667G>A; p.G556D; 3:20127467-20127467	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.306C>T; p.A102A; 3:20072335-20072335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.938G>A; p.R313H; 3:20111682-20111682	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.349T>C; p.S117P; 3:20072378-20072378	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1492G>A; p.V498M; 3:20125983-20125983	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2416G>T; p.E806*; 3:20152442-20152442	skin	malignant_melanoma	Substitution - Nonsense
c.1301C>G; p.S434C; 3:20122692-20122692	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.830G>T; p.G277V; 3:20101447-20101447	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2032C>A; p.Q678K; 3:20146343-20146343	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2035G>A; p.A679T; 3:20146346-20146346	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1601T>G; p.I534S; 3:20126092-20126092	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2035G>A; p.A679T; 3:20146346-20146346	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1972G>A; p.E658K; 3:20140332-20140332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2011delA; p.K672fs*2; 3:20146322-20146322	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.443C>T; p.S148F; 3:20095275-20095275	skin	malignant_melanoma	Substitution - Missense
c.2409delC; p.P805fs*25; 3:20152435-20152435	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2044C>T; p.R682*; 3:20146355-20146355	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2044C>T; p.R682*; 3:20146355-20146355	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2044C>T; p.R682*; 3:20146355-20146355	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1594G>T; p.E532*; 3:20126085-20126085	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1083C>G; p.N361K; 3:20114921-20114921	breast	carcinoma	Substitution - Missense
c.1594G>T; p.E532*; 3:20126085-20126085	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1388A>G; p.D463G; 3:20122779-20122779	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1157A>G; p.N386S; 3:20119604-20119604	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2052T>G; p.V684V; 3:20146363-20146363	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.760C>T; p.R254C; 3:20101377-20101377	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.568C>T; p.L190L; 3:20095400-20095400	skin	malignant_melanoma	Substitution - coding silent
c.1165C>T; p.P389S; 3:20119612-20119612	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.568C>T; p.L190L; 3:20095400-20095400	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2156+5G>A; p.?; 3:20148004-20148004	ovary	other; neoplasm	Unknown
c.2297_2298insC; p.M768fs*8; 3:20148479-20148480	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1188C>A; p.Y396*; 3:20119635-20119635	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.457G>A; p.V153M; 3:20095289-20095289	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1199C>G; p.S400*; 3:20119646-20119646	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1831G>A; p.E611K; 3:20137023-20137023	skin	malignant_melanoma	Substitution - Missense
c.457G>A; p.V153M; 3:20095289-20095289	ovary	other; neoplasm	Substitution - Missense
c.1651G>A; p.D551N; 3:20127451-20127451	NS	NS	Substitution - Missense
c.1155C>A; p.I385I; 3:20119602-20119602	breast	carcinoma	Substitution - coding silent
c.275A>G; p.E92G; 3:20040752-20040752	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2368G>A; p.A790T; 3:20152394-20152394	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1843G>A; p.G615R; 3:20137035-20137035	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1843G>A; p.G615R; 3:20137035-20137035	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1469G>A; p.R490H; 3:20125960-20125960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1469G>A; p.R490H; 3:20125960-20125960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1469G>A; p.R490H; 3:20125960-20125960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1469G>A; p.R490H; 3:20125960-20125960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1560C>T; p.N520N; 3:20126051-20126051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1560C>T; p.N520N; 3:20126051-20126051	breast	carcinoma	Substitution - coding silent
c.1730C>T; p.T577I; 3:20127530-20127530	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1571A>G; p.H524R; 3:20126062-20126062	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.313T>C; p.S105P; 3:20072342-20072342	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.309G>A; p.E103E; 3:20072338-20072338	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.309G>A; p.E103E; 3:20072338-20072338	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.309G>A; p.E103E; 3:20072338-20072338	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1016G>A; p.R339Q; 3:20111760-20111760	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2137C>A; p.P713T; 3:20147980-20147980	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2095C>T; p.P699S; 3:20146406-20146406	skin	malignant_melanoma	Substitution - Missense
c.1670G>T; p.G557V; 3:20127470-20127470	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.658A>G; p.S220G; 3:20099943-20099943	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.331_332insG; p.K112fs*4; 3:20072360-20072361	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.668A>T; p.Q223L; 3:20099953-20099953	skin	malignant_melanoma	Substitution - Missense
c.212G>T; p.G71V; 3:20040689-20040689	central_nervous_system; brain	glioma	Substitution - Missense
c.1403T>A; p.L468H; 3:20122794-20122794	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1964C>T; p.P655L; 3:20140324-20140324	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1425G>A; p.L475L; 3:20125916-20125916	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1088C>T; p.P363L; 3:20114926-20114926	skin	malignant_melanoma	Substitution - Missense
c.1044-1G>A; p.?; 3:20114881-20114881	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.1680C>T; p.F560F; 3:20127480-20127480	skin	malignant_melanoma	Substitution - coding silent
c.1339G>T; p.G447W; 3:20122730-20122730	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2205C>T; p.I735I; 3:20148291-20148291	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.821A>G; p.D274G; 3:20101438-20101438	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.625T>A; p.S209T; 3:20099910-20099910	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>T; p.K212N; 3:20099921-20099921	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2498G>A; p.833; 3:20152524-20152524	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.636G>T; p.K212N; 3:20099921-20099921	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2027G>T; p.R676I; 3:20146338-20146338	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.299G>A; p.C100Y; 3:20040776-20040776	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2381G>A; p.R794Q; 3:20152407-20152407	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1525A>G; p.K509E; 3:20126016-20126016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.761G>A; p.R254H; 3:20101378-20101378	pancreas	carcinoma	Substitution - Missense
c.2045G>A; p.R682Q; 3:20146356-20146356	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2045G>A; p.R682Q; 3:20146356-20146356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1560C>A; p.N520K; 3:20126051-20126051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1700G>C; p.G567A; 3:20127500-20127500	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2378A>T; p.Q793L; 3:20152404-20152404	liver	carcinoma	Substitution - Missense
c.2378A>T; p.Q793L; 3:20152404-20152404	liver	carcinoma	Substitution - Missense
c.430+4A>C; p.?; 3:20072463-20072463	liver	carcinoma	Unknown
c.1365C>T; p.N455N; 3:20122756-20122756	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1853A>G; p.K618R; 3:20137045-20137045	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.669+6A>C; p.?; 3:20099960-20099960	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.409C>T; p.R137W; 3:20072438-20072438	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.409C>T; p.R137W; 3:20072438-20072438	pancreas	carcinoid-endocrine_tumour; islet_cell	Substitution - Missense
c.369C>T; p.A123A; 3:20072398-20072398	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029C>T; p.L343L; 3:20111773-20111773	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1607G>A; p.R536Q; 3:20126098-20126098	breast	carcinoma	Substitution - Missense
c.1060G>T; p.E354*; 3:20114898-20114898	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1536G>T; p.L512L; 3:20126027-20126027	breast	carcinoma	Substitution - coding silent
c.404C>T; p.S135F; 3:20072433-20072433	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1907A>T; p.Y636F; 3:20140267-20140267	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1199C>T; p.S400L; 3:20119646-20119646	skin	malignant_melanoma	Substitution - Missense
c.522T>A; p.C174*; 3:20095354-20095354	skin	malignant_melanoma	Substitution - Nonsense
c.833A>T; p.Y278F; 3:20101450-20101450	skin	malignant_melanoma	Substitution - Missense
c.1623-2A>G; p.?; 3:20127421-20127421	lung	carcinoma; small_cell_carcinoma	Unknown
c.991A>G; p.K331E; 3:20111735-20111735	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1274C>A; p.P425Q; 3:20119721-20119721	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.309G>T; p.E103D; 3:20072338-20072338	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1774C>T; p.H592Y; 3:20136966-20136966	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1483G>T; p.E495*; 3:20125974-20125974	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1704C>T; p.F568F; 3:20127504-20127504	breast	carcinoma	Substitution - coding silent
c.1396G>A; p.A466T; 3:20122787-20122787	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.871G>A; p.V291M; 3:20111615-20111615	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2236T>C; p.W746R; 3:20148418-20148418	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.458T>C; p.V153A; 3:20095290-20095290	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458T>C; p.V153A; 3:20095290-20095290	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.560A>G; p.Y187C; 3:20095392-20095392	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1783G>C; p.E595Q; 3:20136975-20136975	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718G>T; p.E240*; 3:20101335-20101335	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.430+2T>C; p.?; 3:20072461-20072461	stomach	carcinoma; adenocarcinoma	Unknown
c.1159C>A; p.P387T; 3:20119606-20119606	kidney	other; neoplasm	Substitution - Missense
c.1276+7T>A; p.?; 3:20119730-20119730	kidney	other; neoplasm	Unknown
c.1102G>A; p.D368N; 3:20114940-20114940	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1844G>T; p.G615V; 3:20137036-20137036	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1844G>T; p.G615V; 3:20137036-20137036	urinary_tract; bladder	carcinoma	Substitution - Missense
c.392G>A; p.S131N; 3:20072421-20072421	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.410G>A; p.R137Q; 3:20072439-20072439	breast	carcinoma	Substitution - Missense
c.544G>T; p.D182Y; 3:20095376-20095376	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1276+8C>T; p.?; 3:20119731-20119731	kidney	other; neoplasm	Unknown
c.2087G>A; p.R696Q; 3:20146398-20146398	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1331G>A; p.R444Q; 3:20122722-20122722	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.962G>A; p.R321Q; 3:20111706-20111706	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1757G>T; p.G586V; 3:20136949-20136949	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1583G>A; p.R528Q; 3:20126074-20126074	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2351C>G; p.S784C; 3:20152377-20152377	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.557T>A; p.V186D; 3:20095389-20095389	skin	malignant_melanoma	Substitution - Missense
c.1387G>A; p.D463N; 3:20122778-20122778	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1611C>T; p.L537L; 3:20126102-20126102	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1198T>A; p.S400T; 3:20119645-20119645	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2220+2T>G; p.?; 3:20148308-20148308	breast	carcinoma	Unknown
c.1368G>A; p.E456E; 3:20122759-20122759	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1368G>A; p.E456E; 3:20122759-20122759	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - coding silent
c.1260A>C; p.G420G; 3:20119707-20119707	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.898C>T; p.R300W; 3:20111642-20111642	liver	carcinoma	Substitution - Missense
c.2055C>T; p.Y685Y; 3:20146366-20146366	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.2331C>G; p.L777L; 3:20152357-20152357	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1657C>G; p.R553G; 3:20127457-20127457	skin	malignant_melanoma	Substitution - Missense
c.1260A>G; p.G420G; 3:20119707-20119707	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.2261G>T; p.R754I; 3:20148443-20148443	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1658G>A; p.R553H; 3:20127458-20127458	breast	carcinoma	Substitution - Missense
c.1301C>T; p.S434F; 3:20122692-20122692	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.256C>G; p.P86A; 3:20040733-20040733	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1915G>A; p.D639N; 3:20140275-20140275	skin	malignant_melanoma	Substitution - Missense
c.1873G>T; p.E625*; 3:20140233-20140233	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1915G>A; p.D639N; 3:20140275-20140275	skin	malignant_melanoma	Substitution - Missense
c.1981G>A; p.V661I; 3:20140341-20140341	prostate	carcinoma	Substitution - Missense
c.1038C>T; p.F346F; 3:20111782-20111782	skin	malignant_melanoma	Substitution - coding silent
c.871G>T; p.V291L; 3:20111615-20111615	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1622+1G>T; p.?; 3:20126114-20126114	lung	carcinoma; adenocarcinoma	Unknown
c.429A>C; p.L143L; 3:20072458-20072458	liver	carcinoma	Substitution - coding silent
c.2172C>T; p.D724D; 3:20148258-20148258	skin	malignant_melanoma	Substitution - coding silent
c.1622+2T>C; p.?; 3:20126115-20126115	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1026C>T; p.I342I; 3:20111770-20111770	skin	malignant_melanoma	Substitution - coding silent

The somatic mutations from COSMIC database