Entrez Gene

Basic Information
Gene ID	8614
Name	STC2

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.310A>G; p.K104E; 5:173323415-173323415	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.265C>T; p.L89L; 5:173325897-173325897	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.265C>T; p.L89L; 5:173325897-173325897	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.605G>A; p.G202E; 5:173318151-173318151	skin	malignant_melanoma	Substitution - Missense
c.608G>T; p.S203I; 5:173318148-173318148	pancreas	carcinoma	Substitution - Missense
c.779G>A; p.G260D; 5:173317977-173317977	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.721G>A; p.E241K; 5:173318035-173318035	skin; mucosal	malignant_melanoma	Substitution - Missense
c.488A>G; p.K163R; 5:173323237-173323237	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.176A>T; p.N59I; 5:173325986-173325986	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>T; p.G33C; 5:173328097-173328097	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.662C>T; p.A221V; 5:173318094-173318094	kidney	other; neoplasm	Substitution - Missense
c.656C>T; p.P219L; 5:173318100-173318100	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.639G>A; p.S213S; 5:173318117-173318117	pancreas	carcinoma	Substitution - coding silent
c.708G>T; p.R236S; 5:173318048-173318048	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.388G>A; p.E130K; 5:173323337-173323337	skin	malignant_melanoma	Substitution - Missense
c.624G>A; p.L208L; 5:173318132-173318132	skin	malignant_melanoma	Substitution - coding silent
c.745C>T; p.P249S; 5:173318011-173318011	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.265C>A; p.L89M; 5:173325897-173325897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.412G>A; p.E138K; 5:173323313-173323313	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.807C>T; p.N269N; 5:173317949-173317949	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.106G>T; p.D36Y; 5:173328088-173328088	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.807C>T; p.N269N; 5:173317949-173317949	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - coding silent
c.70G>A; p.G24R; 5:173328124-173328124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.673C>T; p.R225C; 5:173318083-173318083	prostate	carcinoma	Substitution - Missense
c.519C>A; p.D173E; 5:173318237-173318237	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.869G>A; p.W290*; 5:173317887-173317887	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.21C>T; p.G7G; 5:173328173-173328173	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.902G>A; p.R301Q; 5:173317854-173317854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.131G>A; p.R44H; 5:173328063-173328063	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.153G>A; p.A51A; 5:173326009-173326009	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.833G>A; p.G278D; 5:173317923-173317923	pancreas	carcinoma	Substitution - Missense
c.484T>C; p.F162L; 5:173323241-173323241	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.481C>T; p.H161Y; 5:173323244-173323244	liver	carcinoma	Substitution - Missense
c.481C>T; p.H161Y; 5:173323244-173323244	liver	carcinoma	Substitution - Missense
c.672G>A; p.E224E; 5:173318084-173318084	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.672G>A; p.E224E; 5:173318084-173318084	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - coding silent
c.816C>T; p.A272A; 5:173317940-173317940	skin	malignant_melanoma	Substitution - coding silent
c.140T>C; p.L47P; 5:173328054-173328054	pancreas	carcinoma	Substitution - Missense
c.828C>A; p.V276V; 5:173317928-173317928	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.674G>A; p.R225H; 5:173318082-173318082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.28A>G; p.M10V; 5:173328166-173328166	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.216G>A; p.E72E; 5:173325946-173325946	skin	malignant_melanoma	Substitution - coding silent
c.461G>A; p.R154Q; 5:173323264-173323264	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.717C>T; p.H239H; 5:173318039-173318039	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.717C>T; p.H239H; 5:173318039-173318039	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.387G>A; p.R129R; 5:173323338-173323338	skin	malignant_melanoma	Substitution - coding silent
c.387G>A; p.R129R; 5:173323338-173323338	skin	malignant_melanoma	Substitution - coding silent
c.854C>T; p.S285F; 5:173317902-173317902	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.343C>T; p.R115W; 5:173323382-173323382	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.640G>A; p.A214T; 5:173318116-173318116	skin	malignant_melanoma	Substitution - Missense
c.27C>A; p.F9L; 5:173328167-173328167	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.441G>A; p.A147A; 5:173323284-173323284	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.441G>A; p.A147A; 5:173323284-173323284	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.27C>A; p.F9L; 5:173328167-173328167	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.638C>T; p.S213L; 5:173318118-173318118	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.865G>A; p.E289K; 5:173317891-173317891	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.865G>A; p.E289K; 5:173317891-173317891	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.877G>A; p.E293K; 5:173317879-173317879	stomach	adenocarcinoma	Substitution - Missense
c.249G>A; p.G83G; 5:173325913-173325913	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.320T>A; p.L107*; 5:173323405-173323405	liver	carcinoma	Substitution - Nonsense
c.356G>A; p.G119D; 5:173323369-173323369	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.320T>A; p.L107*; 5:173323405-173323405	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.129C>A; p.G43G; 5:173328065-173328065	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.293A>G; p.Q98R; 5:173325869-173325869	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.13C>T; p.R5W; 5:173328181-173328181	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.527A>G; p.N176S; 5:173318229-173318229	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.800A>G; p.H267R; 5:173317956-173317956	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.288T>C; p.D96D; 5:173325874-173325874	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.829G>T; p.G277W; 5:173317927-173317927	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.217A>G; p.N73D; 5:173325945-173325945	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.504C>T; p.H168H; 5:173323221-173323221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.237G>A; p.R79R; 5:173325925-173325925	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.756G>A; p.R252R; 5:173318000-173318000	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.718G>A; p.G240R; 5:173318038-173318038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.709G>A; p.A237T; 5:173318047-173318047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.831G>A; p.G277G; 5:173317925-173317925	skin; foot	malignant_melanoma; acral_lentiginous	Substitution - coding silent
c.832G>A; p.G278S; 5:173317924-173317924	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.94G>C; p.E32Q; 5:173328100-173328100	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.655C>T; p.P219S; 5:173318101-173318101	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.864C>T; p.S288S; 5:173317892-173317892	pancreas	carcinoma	Substitution - coding silent
c.184G>A; p.D62N; 5:173325978-173325978	skin	malignant_melanoma	Substitution - Missense
c.808G>A; p.A270T; 5:173317948-173317948	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.D144N; 5:173323295-173323295	urinary_tract; bladder	carcinoma	Substitution - Missense
c.355G>A; p.G119S; 5:173323370-173323370	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.576C>T; p.S192S; 5:173318180-173318180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.355G>A; p.G119S; 5:173323370-173323370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.316G>A; p.A106T; 5:173323409-173323409	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.71G>C; p.G24A; 5:173328123-173328123	thyroid	carcinoma	Substitution - Missense
c.235C>T; p.R79W; 5:173325927-173325927	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.635_636CC>AA; p.T212K; 5:173318120-173318121	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.847G>A; p.G283R; 5:173317909-173317909	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.620T>C; p.I207T; 5:173318136-173318136	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.745C>A; p.P249T; 5:173318011-173318011	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.833_834insG; p.L279fs*18; 5:173317922-173317923	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Insertion - Frameshift
c.233T>C; p.I78T; 5:173325929-173325929	skin	malignant_melanoma	Substitution - Missense
c.346C>A; p.H116N; 5:173323379-173323379	central_nervous_system; brain	glioma	Substitution - Missense
c.681C>T; p.P227P; 5:173318075-173318075	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.250A>G; p.I84V; 5:173325912-173325912	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.793A>T; p.K265*; 5:173317963-173317963	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.78C>T; p.D26D; 5:173328116-173328116	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.244C>T; p.H82Y; 5:173325918-173325918	thyroid	carcinoma	Substitution - Missense
c.63G>A; p.P21P; 5:173328131-173328131	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.15G>T; p.R5R; 5:173328179-173328179	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.890A>T; p.Y297F; 5:173317866-173317866	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.473A>G; p.E158G; 5:173323252-173323252	skin; mucosal	malignant_melanoma	Substitution - Missense
c.563C>T; p.A188V; 5:173318193-173318193	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.803C>A; p.P268Q; 5:173317953-173317953	skin	malignant_melanoma	Substitution - Missense
c.803C>A; p.P268Q; 5:173317953-173317953	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.588G>A; p.Q196Q; 5:173318168-173318168	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.588G>A; p.Q196Q; 5:173318168-173318168	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.213C>T; p.F71F; 5:173325949-173325949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.213C>T; p.F71F; 5:173325949-173325949	skin; neck	malignant_melanoma	Substitution - coding silent
c.213C>T; p.F71F; 5:173325949-173325949	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.687G>A; p.V229V; 5:173318069-173318069	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.213C>T; p.F71F; 5:173325949-173325949	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.611T>C; p.L204P; 5:173318145-173318145	pancreas	carcinoma	Substitution - Missense
c.272A>G; p.N91S; 5:173325890-173325890	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.236G>T; p.R79L; 5:173325926-173325926	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.36G>A; p.L12L; 5:173328158-173328158	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent

The somatic mutations from COSMIC database