Entrez Gene

Basic Information
Gene ID	8600
Name	TNFSF11

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.895C>G; p.L299V; 13:42606859-42606859	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.434-1G>A; p.?; 13:42600882-42600882	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.891C>T; p.S297S; 13:42606855-42606855	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.940C>T; p.R314*; 13:42606904-42606904	skin	malignant_melanoma	Substitution - Nonsense
c.734C>T; p.T245I; 13:42606698-42606698	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.734C>T; p.T245I; 13:42606698-42606698	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.668G>A; p.R223Q; 13:42606632-42606632	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.734C>T; p.T245I; 13:42606698-42606698	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.940C>T; p.R314*; 13:42606904-42606904	skin	malignant_melanoma	Substitution - Nonsense
c.668G>A; p.R223Q; 13:42606632-42606632	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.798G>A; p.G266G; 13:42606762-42606762	skin	malignant_melanoma	Substitution - coding silent
c.798G>A; p.G266G; 13:42606762-42606762	skin	malignant_melanoma	Substitution - coding silent
c.798G>A; p.G266G; 13:42606762-42606762	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.755C>A; p.S252Y; 13:42606719-42606719	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.840T>A; p.F280L; 13:42606804-42606804	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.346T>A; p.C116S; 13:42581252-42581252	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.717G>T; p.M239I; 13:42606681-42606681	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.435G>A; p.A145A; 13:42600884-42600884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.445G>C; p.G149R; 13:42600894-42600894	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.656_657insG; p.N219fs*8; 13:42606620-42606621	lung	carcinoma; small_cell_carcinoma	Insertion - Frameshift
c.434C>T; p.A145V; 13:42600883-42600883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.285A>C; p.E95D; 13:42581191-42581191	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.402C>T; p.I134I; 13:42600766-42600766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.611G>A; p.G204E; 13:42606575-42606575	skin	malignant_melanoma	Substitution - Missense
c.266G>A; p.R89K; 13:42581172-42581172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.536C>T; p.S179F; 13:42606500-42606500	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.572G>A; p.R191Q; 13:42606536-42606536	skin	malignant_melanoma	Substitution - Missense
c.572G>A; p.R191Q; 13:42606536-42606536	skin	malignant_melanoma	Substitution - Missense
c.353G>T; p.R118I; 13:42581259-42581259	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.387G>T; p.K129N; 13:42581293-42581293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.768G>A; p.M256I; 13:42606732-42606732	skin	malignant_melanoma	Substitution - Missense
c.646C>T; p.L216L; 13:42606610-42606610	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.890C>T; p.S297F; 13:42606854-42606854	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.438G>A; p.M146I; 13:42600887-42600887	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.527C>T; p.P176L; 13:42600976-42600976	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.295T>G; p.F99V; 13:42581201-42581201	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.233G>A; p.R78K; 13:42581139-42581139	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.857G>C; p.G286A; 13:42606821-42606821	urinary_tract; bladder	carcinoma	Substitution - Missense
c.415C>T; p.H139Y; 13:42600779-42600779	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.783C>G; p.T261T; 13:42606747-42606747	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.877G>T; p.V293F; 13:42606841-42606841	liver	carcinoma	Substitution - Missense
c.721T>C; p.Y241H; 13:42606685-42606685	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.877G>T; p.V293F; 13:42606841-42606841	liver	carcinoma	Substitution - Missense
c.721T>C; p.Y241H; 13:42606685-42606685	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.190G>A; p.V64I; 13:42574493-42574493	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.874G>A; p.E292K; 13:42606838-42606838	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.910G>T; p.D304Y; 13:42606874-42606874	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.920A>G; p.Y307C; 13:42606884-42606884	liver	carcinoma	Substitution - Missense
c.585G>T; p.K195N; 13:42606549-42606549	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.920A>G; p.Y307C; 13:42606884-42606884	liver	carcinoma	Substitution - Missense
c.823A>G; p.I275V; 13:42606787-42606787	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.225T>C; p.D75D; 13:42581131-42581131	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.610G>T; p.G204*; 13:42606574-42606574	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.876G>A; p.E292E; 13:42606840-42606840	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.241G>A; p.E81K; 13:42581147-42581147	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.241G>A; p.E81K; 13:42581147-42581147	urinary_tract; bladder	carcinoma	Substitution - Missense
c.907C>T; p.Q303*; 13:42606871-42606871	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.773G>A; p.G258E; 13:42606737-42606737	skin	malignant_melanoma	Substitution - Missense
c.776G>A; p.G259E; 13:42606740-42606740	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.886C>T; p.P296S; 13:42606850-42606850	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.886C>T; p.P296S; 13:42606850-42606850	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.189C>T; p.S63S; 13:42574492-42574492	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.429G>A; p.E143E; 13:42600793-42600793	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.223G>A; p.D75N; 13:42581129-42581129	skin	malignant_melanoma	Substitution - Missense
c.137G>A; p.R46H; 13:42574440-42574440	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.930T>C; p.A310A; 13:42606894-42606894	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.492T>A; p.P164P; 13:42600941-42600941	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.135C>T; p.S45S; 13:42574438-42574438	skin	malignant_melanoma	Substitution - coding silent
c.588C>T; p.I196I; 13:42606552-42606552	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.348T>C; p.C116C; 13:42581254-42581254	prostate	carcinoma	Substitution - coding silent
c.636C>A; p.G212G; 13:42606600-42606600	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.126T>C; p.P42P; 13:42574429-42574429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.126T>C; p.P42P; 13:42574429-42574429	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.126T>C; p.P42P; 13:42574429-42574429	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.126T>C; p.P42P; 13:42574429-42574429	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.126T>C; p.P42P; 13:42574429-42574429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.481G>T; p.E161*; 13:42600930-42600930	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.481G>T; p.E161*; 13:42600930-42600930	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.481G>T; p.E161*; 13:42600930-42600930	large_intestine; colon	carcinoma	Substitution - Nonsense
c.481G>T; p.E161*; 13:42600930-42600930	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.519C>T; p.T173T; 13:42600968-42600968	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.242A>G; p.E81G; 13:42581148-42581148	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.107C>G; p.P36R; 13:42574410-42574410	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.414G>A; p.Q138Q; 13:42600778-42600778	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.667C>T; p.R223*; 13:42606631-42606631	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.676G>T; p.E226*; 13:42606640-42606640	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.235A>G; p.I79V; 13:42581141-42581141	liver	carcinoma	Substitution - Missense
c.235A>G; p.I79V; 13:42581141-42581141	liver	carcinoma	Substitution - Missense
c.468G>A; p.K156K; 13:42600917-42600917	skin	malignant_melanoma	Substitution - coding silent
c.903G>A; p.P301P; 13:42606867-42606867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.524T>A; p.I175N; 13:42600973-42600973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.903G>A; p.P301P; 13:42606867-42606867	pancreas	carcinoma	Substitution - coding silent
c.344C>A; p.S115*; 13:42581250-42581250	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.850C>T; p.R284W; 13:42606814-42606814	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.928G>A; p.A310T; 13:42606892-42606892	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.676G>A; p.E226K; 13:42606640-42606640	skin	malignant_melanoma	Substitution - Missense
c.854C>T; p.S285F; 13:42606818-42606818	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.673C>A; p.H225N; 13:42606637-42606637	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database