Entrez Gene

Basic Information
Gene ID	84695
Name	LOXL3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1530C>G; p.T510T; 2:74535341-74535341	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.31C>T; p.P11S; 2:74552604-74552604	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1194T>G; p.H398Q; 2:74536050-74536050	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.731A>G; p.H244R; 2:74536890-74536890	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1735C>T; p.R579*; 2:74534619-74534619	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1307G>A; p.G436E; 2:74535697-74535697	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.824_825insG; p.A277fs*57; 2:74536796-74536797	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1317C>T; p.P439P; 2:74535687-74535687	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.824_825insG; p.A277fs*57; 2:74536796-74536797	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.824_825insG; p.A277fs*57; 2:74536796-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.824_825insG; p.A277fs*57; 2:74536796-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.824_825insG; p.A277fs*57; 2:74536796-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1179T>C; p.A393A; 2:74536065-74536065	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1267C>T; p.R423C; 2:74535737-74535737	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1267C>T; p.R423C; 2:74535737-74535737	large_intestine; colon	carcinoma	Substitution - Missense
c.55C>T; p.L19L; 2:74552580-74552580	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.55C>T; p.L19L; 2:74552580-74552580	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1766G>A; p.R589Q; 2:74534588-74534588	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1054A>T; p.S352C; 2:74536330-74536330	thyroid	other; neoplasm	Substitution - Missense
c.211G>T; p.D71Y; 2:74552424-74552424	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1205C>T; p.A402V; 2:74536039-74536039	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1852_1855delCACT; p.H618fs*66; 2:74534400-74534403	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.151_152insC; p.R51fs*15; 2:74552483-74552484	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.777C>T; p.S259S; 2:74536844-74536844	skin	malignant_melanoma	Substitution - coding silent
c.1113G>C; p.L371L; 2:74536131-74536131	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1113G>C; p.L371L; 2:74536131-74536131	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2071C>A; p.L691I; 2:74534105-74534105	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.268G>C; p.E90Q; 2:74552367-74552367	urinary_tract; bladder	carcinoma	Substitution - Missense
c.956G>A; p.R319Q; 2:74536428-74536428	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.753G>A; p.T251T; 2:74536868-74536868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1686C>T; p.A562A; 2:74534668-74534668	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1641G>A; p.R547R; 2:74534713-74534713	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.128G>A; p.R43Q; 2:74552507-74552507	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1050C>T; p.F350F; 2:74536334-74536334	oesophagus	carcinoma	Substitution - coding silent
c.1050C>T; p.F350F; 2:74536334-74536334	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.914C>T; p.A305V; 2:74536470-74536470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.208T>G; p.C70G; 2:74552427-74552427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2046G>A; p.T682T; 2:74534130-74534130	skin	malignant_melanoma	Substitution - coding silent
c.2114A>C; p.D705A; 2:74533956-74533956	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1817G>A; p.C606Y; 2:74534537-74534537	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1149C>G; p.L383L; 2:74536095-74536095	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2145C>T; p.C715C; 2:74533925-74533925	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1792C>T; p.R598C; 2:74534562-74534562	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1925C>T; p.T642I; 2:74534330-74534330	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1399G>A; p.A467T; 2:74535605-74535605	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.155A>T; p.K52M; 2:74552480-74552480	skin	malignant_melanoma	Substitution - Missense
c.1001G>A; p.R334H; 2:74536383-74536383	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1813G>C; p.E605Q; 2:74534541-74534541	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1992G>T; p.V664V; 2:74534184-74534184	skin	malignant_melanoma	Substitution - coding silent
c.404C>T; p.T135M; 2:74550258-74550258	breast	carcinoma	Substitution - Missense
c.404C>T; p.T135M; 2:74550258-74550258	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1843A>T; p.I615F; 2:74534412-74534412	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1843A>T; p.I615F; 2:74534412-74534412	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1400C>A; p.A467D; 2:74535604-74535604	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.937G>A; p.A313T; 2:74536447-74536447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1167G>C; p.K389N; 2:74536077-74536077	skin	malignant_melanoma	Substitution - Missense
c.443G>A; p.R148H; 2:74550219-74550219	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1372G>A; p.A458T; 2:74535632-74535632	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.443G>A; p.R148H; 2:74550219-74550219	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.800A>T; p.D267V; 2:74536821-74536821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.31C>A; p.P11T; 2:74552604-74552604	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.737T>A; p.V246E; 2:74536884-74536884	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.442C>T; p.R148C; 2:74550220-74550220	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.643G>A; p.G215R; 2:74549418-74549418	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.184C>T; p.R62*; 2:74552451-74552451	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.824delG; p.G275fs*5; 2:74536797-74536797	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1724G>A; p.R575Q; 2:74534630-74534630	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1940-2A>G; p.?; 2:74534238-74534238	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.557A>G; p.E186G; 2:74549504-74549504	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.909G>A; p.G303G; 2:74536712-74536712	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1899C>T; p.H633H; 2:74534356-74534356	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1053G>A; p.G351G; 2:74536331-74536331	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1869C>T; p.T623T; 2:74534386-74534386	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1639C>T; p.R547W; 2:74534715-74534715	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1127G>A; p.C376Y; 2:74536117-74536117	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1871C>A; p.P624Q; 2:74534384-74534384	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1027G>A; p.V343M; 2:74536357-74536357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1416G>T; p.Q472H; 2:74535588-74535588	stomach	adenocarcinoma	Substitution - Missense
c.554C>T; p.T185M; 2:74549507-74549507	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1365C>T; p.A455A; 2:74535639-74535639	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.977G>A; p.S326N; 2:74536407-74536407	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1332C>T; p.L444L; 2:74535672-74535672	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1290C>T; p.V430V; 2:74535714-74535714	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1149C>T; p.L383L; 2:74536095-74536095	breast	carcinoma	Substitution - coding silent
c.1288G>A; p.V430I; 2:74535716-74535716	breast	carcinoma	Substitution - Missense
c.50G>A; p.C17Y; 2:74552585-74552585	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.207C>T; p.I69I; 2:74552428-74552428	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.390G>A; p.G130G; 2:74550272-74550272	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1155G>A; p.K385K; 2:74536089-74536089	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.692+1G>T; p.?; 2:74549368-74549368	urinary_tract; bladder	carcinoma	Unknown
c.344G>C; p.S115T; 2:74550318-74550318	skin	malignant_melanoma	Substitution - Missense
c.827delC; p.P276fs*4; 2:74536794-74536794	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.133C>T; p.R45W; 2:74552502-74552502	liver	carcinoma	Substitution - Missense
c.1081C>T; p.R361C; 2:74536303-74536303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1793G>A; p.R598H; 2:74534561-74534561	breast	carcinoma	Substitution - Missense
c.946G>C; p.G316R; 2:74536438-74536438	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1471C>T; p.R491C; 2:74535400-74535400	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1232C>T; p.T411I; 2:74536012-74536012	lung	carcinoid-endocrine_tumour; atypical	Substitution - Missense
c.444C>G; p.R148R; 2:74550218-74550218	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.861C>T; p.Y287Y; 2:74536760-74536760	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2038G>A; p.D680N; 2:74534138-74534138	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1508C>T; p.A503V; 2:74535363-74535363	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1508C>T; p.A503V; 2:74535363-74535363	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.334T>C; p.L112L; 2:74550328-74550328	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1508C>T; p.A503V; 2:74535363-74535363	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1398C>T; p.Y466Y; 2:74535606-74535606	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1741T>C; p.S581P; 2:74534613-74534613	skin	malignant_melanoma	Substitution - Missense
c.775T>C; p.S259P; 2:74536846-74536846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2071C>T; p.L691F; 2:74534105-74534105	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2106A>T; p.A702A; 2:74533964-74533964	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1121T>C; p.V374A; 2:74536123-74536123	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.450T>C; p.P150P; 2:74550212-74550212	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1337G>T; p.C446F; 2:74535667-74535667	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1828T>C; p.Y610H; 2:74534427-74534427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1345G>A; p.D449N; 2:74535659-74535659	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1917C>T; p.L639L; 2:74534338-74534338	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.983G>T; p.W328L; 2:74536401-74536401	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.838A>G; p.S280G; 2:74536783-74536783	skin	malignant_melanoma	Substitution - Missense
c.1957G>T; p.E653*; 2:74534219-74534219	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.821G>A; p.G274E; 2:74536800-74536800	skin	malignant_melanoma	Substitution - Missense
c.1119A>G; p.E373E; 2:74536125-74536125	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.175G>C; p.E59Q; 2:74552460-74552460	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1957G>T; p.E653*; 2:74534219-74534219	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Nonsense
c.1051G>A; p.G351R; 2:74536333-74536333	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1082G>A; p.R361H; 2:74536302-74536302	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.733G>A; p.G245R; 2:74536888-74536888	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1516delG; p.G506fs*179; 2:74535355-74535355	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Deletion - Frameshift
c.1292A>G; p.E431G; 2:74535712-74535712	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.5G>C; p.R2P; 2:74552630-74552630	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1624G>A; p.A542T; 2:74534730-74534730	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1152G>A; p.W384*; 2:74536092-74536092	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2081T>A; p.V694D; 2:74533989-74533989	breast	carcinoma	Substitution - Missense
c.1328G>T; p.G443V; 2:74535676-74535676	breast	carcinoma	Substitution - Missense

The somatic mutations from COSMIC database