Entrez Gene

Basic Information
Gene ID	8452
Name	CUL3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1791C>A; p.F597L; 2:224495883-224495883	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.922A>C; p.N308H; 2:224506965-224506965	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1855G>C; p.E619Q; 2:224482066-224482066	breast	carcinoma	Substitution - Missense
c.493_494delCT; p.L165fs*37; 2:224514657-224514658	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.678A>G; p.A226A; 2:224511559-224511559	breast	carcinoma	Substitution - coding silent
c.531C>T; p.V177V; 2:224514620-224514620	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.454G>A; p.V152I; 2:224514697-224514697	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2029G>T; p.V677F; 2:224481892-224481892	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2016C>G; p.V672V; 2:224481905-224481905	breast	carcinoma	Substitution - coding silent
c.622C>T; p.P208S; 2:224513556-224513556	skin	malignant_melanoma	Substitution - Missense
c.1843-5T>G; p.?; 2:224482083-224482083	pancreas	carcinoma	Unknown
c.1597G>C; p.E533Q; 2:224500376-224500376	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.48G>A; p.M16I; 2:224584962-224584962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.365T>C; p.I122T; 2:224535541-224535541	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2112A>G; p.E704E; 2:224478263-224478263	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.245C>G; p.T82S; 2:224557678-224557678	kidney	other; neoplasm	Substitution - Missense
c.274G>C; p.D92H; 2:224535632-224535632	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1072G>C; p.E358Q; 2:224506090-224506090	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1098delT; p.F366fs*31; 2:224506064-224506064	oesophagus	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1417A>T; p.M473L; 2:224503033-224503033	skin	malignant_melanoma	Substitution - Missense
c.2126G>A; p.R709Q; 2:224478249-224478249	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.809C>T; p.S270F; 2:224511428-224511428	skin; leg	malignant_melanoma; superficial_spreading	Substitution - Missense
c.1263T>A; p.F421L; 2:224503766-224503766	liver	carcinoma	Substitution - Missense
c.5C>A; p.S2*; 2:224585005-224585005	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.1611G>T; p.R537S; 2:224497849-224497849	thyroid	carcinoma	Substitution - Missense
c.602A>G; p.Y201C; 2:224513576-224513576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.124C>T; p.Q42*; 2:224557799-224557799	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.602A>G; p.Y201C; 2:224513576-224513576	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.664C>A; p.Q222K; 2:224511573-224511573	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.235G>T; p.E79*; 2:224557688-224557688	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1616A>G; p.Y539C; 2:224497844-224497844	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1795A>G; p.M599V; 2:224495879-224495879	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1276G>C; p.D426H; 2:224503753-224503753	oesophagus	carcinoma	Substitution - Missense
c.460T>C; p.Y154H; 2:224514691-224514691	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.150T>C; p.S50S; 2:224557773-224557773	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1516C>T; p.R506W; 2:224500457-224500457	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.60C>T; p.A20A; 2:224584950-224584950	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2000C>T; p.S667F; 2:224481921-224481921	skin	malignant_melanoma	Substitution - Missense
c.600C>T; p.V200V; 2:224513578-224513578	breast	carcinoma	Substitution - coding silent
c.433A>C; p.I145L; 2:224514718-224514718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1676T>G; p.L559R; 2:224497784-224497784	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.277G>A; p.V93I; 2:224535629-224535629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1066C>T; p.L356F; 2:224506096-224506096	skin	malignant_melanoma	Substitution - Missense
c.1644C>T; p.L548L; 2:224497816-224497816	breast	carcinoma	Substitution - coding silent
c.913C>T; p.R305C; 2:224506974-224506974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1739C>T; p.A580V; 2:224495935-224495935	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1448C>T; p.T483M; 2:224503002-224503002	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2212C>T; p.P738S; 2:224474340-224474340	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2027C>T; p.T676I; 2:224481894-224481894	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.395A>G; p.Q132R; 2:224514756-224514756	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2192A>T; p.K731M; 2:224474360-224474360	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.149G>A; p.S50N; 2:224557774-224557774	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1766A>C; p.K589T; 2:224495908-224495908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.764C>G; p.S255*; 2:224511473-224511473	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1000G>A; p.E334K; 2:224506887-224506887	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1862A>G; p.D621G; 2:224482059-224482059	liver	carcinoma	Substitution - Missense
c.2278G>A; p.D760N; 2:224474274-224474274	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.652C>T; p.Q218*; 2:224513526-224513526	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2133G>A; p.M711I; 2:224478242-224478242	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.787G>A; p.V263M; 2:224511450-224511450	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2282G>A; p.R761H; 2:224474270-224474270	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.834A>G; p.E278E; 2:224511403-224511403	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1892T>G; p.L631R; 2:224482029-224482029	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1378-1G>A; p.?; 2:224503073-224503073	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.18A>T; p.K6N; 2:224584992-224584992	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.198G>T; p.L66F; 2:224557725-224557725	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1994T>A; p.F665Y; 2:224481927-224481927	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1631G>A; p.S544N; 2:224497829-224497829	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1631G>A; p.S544N; 2:224497829-224497829	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.649T>G; p.F217V; 2:224513529-224513529	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2256A>G; p.E752E; 2:224474296-224474296	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1637G>C; p.R546P; 2:224497823-224497823	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2256A>G; p.E752E; 2:224474296-224474296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2029+1G>A; p.?; 2:224481891-224481891	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.89delT; p.V30fs*8; 2:224557834-224557834	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.230T>C; p.L77P; 2:224557693-224557693	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.412A>G; p.N138D; 2:224514739-224514739	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.716C>T; p.A239V; 2:224511521-224511521	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1219G>T; p.E407*; 2:224503810-224503810	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.464G>A; p.G155E; 2:224514687-224514687	breast	carcinoma	Substitution - Missense
c.2164C>G; p.L722V; 2:224478211-224478211	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.85T>C; p.Y29H; 2:224557838-224557838	skin	malignant_melanoma	Substitution - Missense
c.1047G>T; p.K349N; 2:224506115-224506115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.184T>C; p.Y62H; 2:224557739-224557739	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.159T>G; p.S53R; 2:224557764-224557764	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1939G>A; p.E647K; 2:224481982-224481982	skin	malignant_melanoma	Substitution - Missense
c.91A>C; p.N31H; 2:224557832-224557832	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.544G>T; p.A182S; 2:224513634-224513634	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1193A>G; p.K398R; 2:224505969-224505969	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>C; p.G70R; 2:224557715-224557715	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.E243K; 2:224511510-224511510	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1325C>G; p.T442R; 2:224503704-224503704	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.581G>A; p.G194D; 2:224513597-224513597	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2252G>C; p.R751T; 2:224474300-224474300	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.76G>T; p.D26Y; 2:224557847-224557847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1376A>T; p.K459M; 2:224503653-224503653	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.415G>T; p.V139F; 2:224514736-224514736	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.415G>T; p.V139F; 2:224514736-224514736	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.79G>A; p.E27K; 2:224557844-224557844	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1314_1316delGAG; p.R439delR; 2:224503713-224503715	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.142A>T; p.N48Y; 2:224557781-224557781	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2068G>T; p.E690*; 2:224478307-224478307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1902_1903insCCTC; p.A635fs*5; 2:224482018-224482019	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.608A>T; p.E203V; 2:224513570-224513570	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1637G>A; p.R546Q; 2:224497823-224497823	stomach	adenocarcinoma	Substitution - Missense
c.655-1G>A; p.?; 2:224511583-224511583	lung	carcinoma; adenocarcinoma	Unknown
c.458G>A; p.R153H; 2:224514693-224514693	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1568A>G; p.N523S; 2:224500405-224500405	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.914G>A; p.R305H; 2:224506973-224506973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1708-1G>T; p.?; 2:224495967-224495967	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.585C>T; p.L195L; 2:224513593-224513593	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.845C>A; p.S282Y; 2:224511392-224511392	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1138C>A; p.L380I; 2:224506024-224506024	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.36G>T; p.K12N; 2:224584974-224584974	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.36G>T; p.K12N; 2:224584974-224584974	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.36G>T; p.K12N; 2:224584974-224584974	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - Missense
c.36G>T; p.K12N; 2:224584974-224584974	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2077C>G; p.Q693E; 2:224478298-224478298	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.269G>A; p.R90Q; 2:224535637-224535637	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.827_828insT; p.V277fs*28; 2:224511409-224511410	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.2106G>C; p.E702D; 2:224478269-224478269	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.383G>C; p.R128P; 2:224514768-224514768	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.722T>G; p.I241S; 2:224511515-224511515	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.625T>A; p.F209I; 2:224513553-224513553	skin	malignant_melanoma	Substitution - Missense
c.2197C>T; p.R733*; 2:224474355-224474355	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2154G>A; p.Q718Q; 2:224478221-224478221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1843-4delT; p.?; 2:224482082-224482082	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Unknown
c.1354A>G; p.K452E; 2:224503675-224503675	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1868C>T; p.P623L; 2:224482053-224482053	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1735G>A; p.G579S; 2:224495939-224495939	skin	malignant_melanoma	Substitution - Missense
c.1756A>G; p.N586D; 2:224495918-224495918	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.241G>A; p.V81I; 2:224557682-224557682	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.154C>G; p.L52V; 2:224557769-224557769	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.154C>G; p.L52V; 2:224557769-224557769	urinary_tract; bladder	carcinoma	Substitution - Missense
c.595T>A; p.S199T; 2:224513583-224513583	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.886C>A; p.L296I; 2:224507001-224507001	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1931_1938delTTACAAAA; p.L644fs*16; 2:224481983-224481990	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.1285G>A; p.E429K; 2:224503744-224503744	breast	carcinoma	Substitution - Missense
c.989C>A; p.S330Y; 2:224506898-224506898	urinary_tract; bladder	carcinoma	Substitution - Missense
c.504G>A; p.M168I; 2:224514647-224514647	pancreas	carcinoma	Substitution - Missense
c.843T>C; p.N281N; 2:224511394-224511394	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.37G>A; p.D13N; 2:224584973-224584973	skin	malignant_melanoma	Substitution - Missense
c.1903G>A; p.A635T; 2:224482018-224482018	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1843G>T; p.E615*; 2:224482078-224482078	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2248G>A; p.E750K; 2:224474304-224474304	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1687T>G; p.F563V; 2:224497773-224497773	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1687T>G; p.F563V; 2:224497773-224497773	urinary_tract; bladder	carcinoma	Substitution - Missense
c.27C>T; p.G9G; 2:224584983-224584983	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.712G>T; p.E238*; 2:224511525-224511525	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.276T>C; p.D92D; 2:224535630-224535630	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.586G>A; p.E196K; 2:224513592-224513592	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.177A>C; p.R59S; 2:224557746-224557746	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.896T>G; p.M299R; 2:224506991-224506991	prostate	carcinoma	Substitution - Missense
c.145A>G; p.N49D; 2:224557778-224557778	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1366delT; p.S456fs*3; 2:224503663-224503663	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1358_1359insA; p.N453fs*5; 2:224503670-224503671	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.434T>A; p.I145N; 2:224514717-224514717	skin	malignant_melanoma	Substitution - Missense
c.963G>C; p.L321F; 2:224506924-224506924	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1785C>T; p.S595S; 2:224495889-224495889	skin	malignant_melanoma	Substitution - coding silent
c.668A>C; p.K223T; 2:224511569-224511569	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2306A>G; p.769; 2:224474246-224474246	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.231A>C; p.L77L; 2:224557692-224557692	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1611-2A>G; p.?; 2:224497851-224497851	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Unknown
c.540-2A>G; p.?; 2:224513640-224513640	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1554C>T; p.A518A; 2:224500419-224500419	skin	malignant_melanoma	Substitution - coding silent

The somatic mutations from COSMIC database