Entrez Gene

Basic Information
Gene ID	79718
Name	TBL1XR1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.528C>T; p.A176A; 3:177050510-177050510	skin	malignant_melanoma	Substitution - coding silent
c.1460T>C; p.F487S; 3:177026431-177026431	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1460T>C; p.F487S; 3:177026431-177026431	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.764A>G; p.D255G; 3:177047488-177047488	liver	carcinoma	Substitution - Missense
c.1255T>A; p.S419T; 3:177033132-177033132	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1255T>A; p.S419T; 3:177033132-177033132	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.161A>T; p.Q54L; 3:177053816-177053816	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.959_961delACA; p.N320delN; 3:177038399-177038401	breast	carcinoma	Deletion - In frame
c.1473G>C; p.W491C; 3:177026418-177026418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.222T>C; p.D74D; 3:177051709-177051709	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.423_424insTA; p.A142fs*1; 3:177051507-177051508	breast	carcinoma	Insertion - Frameshift
c.423_424insTA; p.A142fs*1; 3:177051507-177051508	breast	carcinoma	Insertion - Frameshift
c.423_424insTA; p.A142fs*1; 3:177051507-177051508	breast	carcinoma	Insertion - Frameshift
c.381_382insA; p.E128fs*17; 3:177051549-177051550	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Insertion - Frameshift
c.98A>G; p.H33R; 3:177053879-177053879	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.100A>G; p.I34V; 3:177053877-177053877	breast	carcinoma	Substitution - Missense
c.232delA; p.I78fs*1; 3:177051699-177051699	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.3G>C; p.M1I; 3:177064975-177064975	breast	carcinoma	Substitution - Missense
c.419_420insCA; p.A142fs*1; 3:177051511-177051512	breast	carcinoma	Insertion - Frameshift
c.9A>G; p.I3M; 3:177064969-177064969	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.R216*; 3:177050053-177050053	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.342C>T; p.A114A; 3:177051589-177051589	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.251_252insC; p.D85fs*6; 3:177051679-177051680	liver	carcinoma	Insertion - Frameshift
c.113A>G; p.N38S; 3:177053864-177053864	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.148A>T; p.I50F; 3:177053829-177053829	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.766+5A>G; p.?; 3:177047481-177047481	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1048-1G>C; p.?; 3:177038173-177038173	prostate	carcinoma; adenocarcinoma	Unknown
c.337G>A; p.A113T; 3:177051594-177051594	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1261G>C; p.D421H; 3:177033126-177033126	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1261G>C; p.D421H; 3:177033126-177033126	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.791A>T; p.Q264L; 3:177047373-177047373	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1003A>C; p.K335Q; 3:177038357-177038357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1128G>T; p.W376C; 3:177034320-177034320	liver	carcinoma	Substitution - Missense
c.204+1G>C; p.?; 3:177053772-177053772	breast	carcinoma	Unknown
c.1462G>A; p.E488K; 3:177026429-177026429	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.840C>T; p.F280F; 3:177047324-177047324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.140C>A; p.A47D; 3:177053837-177053837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.234_235delAG; p.E79fs*11; 3:177051696-177051697	prostate	carcinoma	Deletion - Frameshift
c.585A>G; p.I195M; 3:177050114-177050114	liver	carcinoma	Substitution - Missense
c.585A>G; p.I195M; 3:177050114-177050114	liver	carcinoma	Substitution - Missense
c.35_38delTATA; p.Y13fs*17; 3:177064940-177064943	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Deletion - Frameshift
c.1336T>G; p.Y446D; 3:177033051-177033051	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1339A>G; p.S447G; 3:177033048-177033048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.575C>T; p.T192I; 3:177050124-177050124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.229C>A; p.P77T; 3:177051702-177051702	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.728G>T; p.G243V; 3:177047524-177047524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.596G>A; p.S199N; 3:177050103-177050103	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1007T>C; p.L336S; 3:177038353-177038353	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1046C>T; p.T349M; 3:177038314-177038314	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.345A>C; p.A115A; 3:177051586-177051586	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.974G>C; p.C325S; 3:177038386-177038386	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.562T>A; p.S188T; 3:177050137-177050137	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.168T>A; p.G56G; 3:177053809-177053809	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.258C>T; p.A86A; 3:177051673-177051673	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.614delG; p.G205fs*5; 3:177050085-177050085	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Deletion - Frameshift
c.1387G>A; p.D463N; 3:177033000-177033000	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.283A>C; p.R95R; 3:177051648-177051648	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.496C>T; p.R166W; 3:177050542-177050542	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.832G>A; p.G278R; 3:177047332-177047332	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.504T>C; p.H168H; 3:177050534-177050534	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.763G>T; p.D255Y; 3:177047489-177047489	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.337G>T; p.A113S; 3:177051594-177051594	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.662A>G; p.D221G; 3:177050037-177050037	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1108G>A; p.D370N; 3:177038112-177038112	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.106C>T; p.Q36*; 3:177053871-177053871	breast	carcinoma	Substitution - Nonsense
c.1250G>A; p.S417N; 3:177034198-177034198	skin	malignant_melanoma	Substitution - Missense
c.1250G>A; p.S417N; 3:177034198-177034198	skin	malignant_melanoma	Substitution - Missense
c.920A>T; p.H307L; 3:177046134-177046134	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1457T>G; p.I486R; 3:177026434-177026434	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1183T>C; p.Y395H; 3:177034265-177034265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.691C>G; p.L231V; 3:177050008-177050008	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.868A>G; p.T290A; 3:177046186-177046186	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.202G>A; p.E68K; 3:177053775-177053775	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1122G>T; p.K374N; 3:177038098-177038098	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1489A>T; p.K497*; 3:177026402-177026402	breast	carcinoma	Substitution - Nonsense
c.909G>T; p.Q303H; 3:177046145-177046145	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1256C>T; p.S419F; 3:177033131-177033131	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1256C>T; p.S419F; 3:177033131-177033131	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1256C>T; p.S419F; 3:177033131-177033131	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.497G>A; p.R166Q; 3:177050541-177050541	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.497G>A; p.R166Q; 3:177050541-177050541	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1051G>T; p.E351*; 3:177038169-177038169	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1335G>T; p.V445V; 3:177033052-177033052	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - coding silent
c.70T>C; p.S24P; 3:177053907-177053907	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.632_633ins14; p.R212fs*25; 3:177050066-177050067	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Insertion - Frameshift
c.1177G>T; p.E393*; 3:177034271-177034271	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.253G>C; p.D85H; 3:177051678-177051678	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1177G>T; p.E393*; 3:177034271-177034271	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1177G>T; p.E393*; 3:177034271-177034271	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.520A>G; p.I174V; 3:177050518-177050518	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.862_864+4delAAGGTAA; p.?; 3:177047296-177047302	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Unknown
c.200A>G; p.N67S; 3:177053777-177053777	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Missense
c.1089C>G; p.L363L; 3:177038131-177038131	parathyroid	carcinoma	Substitution - coding silent
c.1510G>T; p.D504Y; 3:177026381-177026381	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.646C>A; p.R216R; 3:177050053-177050053	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1186A>G; p.T396A; 3:177034262-177034262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.127C>T; p.L43F; 3:177053850-177053850	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.127C>T; p.L43F; 3:177053850-177053850	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.511G>A; p.E171K; 3:177050527-177050527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.281C>G; p.T94R; 3:177051650-177051650	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.226C>T; p.R76*; 3:177051705-177051705	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.463G>C; p.V155L; 3:177050575-177050575	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.531G>T; p.W177C; 3:177050507-177050507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.458G>A; p.G153E; 3:177050580-177050580	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.923C>T; p.S308L; 3:177046131-177046131	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1145A>G; p.N382S; 3:177034303-177034303	breast	carcinoma	Substitution - Missense
c.227G>C; p.R76P; 3:177051704-177051704	liver	carcinoma	Substitution - Missense
c.227G>C; p.R76P; 3:177051704-177051704	liver	carcinoma	Substitution - Missense
c.301G>A; p.D101N; 3:177051630-177051630	skin	malignant_melanoma	Substitution - Missense
c.628G>A; p.V210I; 3:177050071-177050071	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - Missense
c.683T>C; p.V228A; 3:177050016-177050016	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1539G>A; p.R513R; 3:177025504-177025504	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.257C>A; p.A86D; 3:177051674-177051674	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.686C>G; p.T229R; 3:177050013-177050013	haematopoietic_and_lymphoid_tissue; skin	lymphoid_neoplasm; mycosis_fungoides-Sezary_syndrome	Substitution - Missense
c.1345G>C; p.A449P; 3:177033042-177033042	ovary	other; neoplasm	Substitution - Missense
c.846A>G; p.L282L; 3:177047318-177047318	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.467A>G; p.E156G; 3:177050571-177050571	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1071G>T; p.W357C; 3:177038149-177038149	ovary	other; neoplasm	Substitution - Missense
c.739G>A; p.G247R; 3:177047513-177047513	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.1376G>A; p.S459N; 3:177033011-177033011	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1015G>T; p.D339Y; 3:177038345-177038345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1531G>C; p.D511H; 3:177025512-177025512	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.377delA; p.N126fs*16; 3:177051554-177051554	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.377delA; p.N126fs*16; 3:177051554-177051554	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.377delA; p.N126fs*16; 3:177051554-177051554	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.377delA; p.N126fs*16; 3:177051554-177051554	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.377delA; p.N126fs*16; 3:177051554-177051554	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.174G>T; p.Q58H; 3:177053803-177053803	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.637C>A; p.H213N; 3:177050062-177050062	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.134C>T; p.P45L; 3:177053843-177053843	urinary_tract; bladder	carcinoma	Substitution - Missense
c.606_624del19; p.T203fs*1; 3:177050075-177050093	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.281C>T; p.T94I; 3:177051650-177051650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.G167D; 3:177050538-177050538	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.977G>A; p.S326N; 3:177038383-177038383	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1340G>A; p.S447N; 3:177033047-177033047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1127G>T; p.W376L; 3:177034321-177034321	urinary_tract; bladder	carcinoma	Substitution - Missense
c.854G>T; p.G285V; 3:177047310-177047310	breast	carcinoma	Substitution - Missense
c.785T>C; p.L262S; 3:177047379-177047379	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1047G>A; p.T349T; 3:177038313-177038313	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1257_1258CT>TC; p.F420L; 3:177033129-177033130	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1047G>A; p.T349T; 3:177038313-177038313	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.422_423delTA; p.I141fs*3; 3:177051508-177051509	breast	carcinoma	Deletion - Frameshift
c.1274G>T; p.R425M; 3:177033113-177033113	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1087C>G; p.L363V; 3:177038133-177038133	urinary_tract; bladder	carcinoma	Substitution - Missense
c.287A>C; p.Q96P; 3:177051644-177051644	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1424C>T; p.A475V; 3:177026467-177026467	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.883G>A; p.A295T; 3:177046171-177046171	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.883G>A; p.A295T; 3:177046171-177046171	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.230C>T; p.P77L; 3:177051701-177051701	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.680A>G; p.D227G; 3:177050019-177050019	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1019G>T; p.R340I; 3:177038341-177038341	lung	carcinoma; adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database