Entrez Gene

Basic Information
Gene ID	780
Name	DDR1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.2197C>T; p.R733W; 6:30898164-30898164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.342C>G; p.F114L; 6:30889355-30889355	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1811C>T; p.P604L; 6:30897066-30897066	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1456G>A; p.E486K; 6:30894614-30894614	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2153G>A; p.R718H; 6:30898120-30898120	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.571C>T; p.L191F; 6:30891385-30891385	breast	carcinoma	Substitution - Missense
c.1836T>A; p.P612P; 6:30897091-30897091	skin	malignant_melanoma	Substitution - coding silent
c.2457C>T; p.N819N; 6:30899004-30899004	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2457C>T; p.N819N; 6:30899004-30899004	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2457C>T; p.N819N; 6:30899004-30899004	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2288A>T; p.Q763L; 6:30898255-30898255	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.383G>A; p.R128H; 6:30889396-30889396	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.383G>A; p.R128H; 6:30889396-30889396	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2192C>T; p.A731V; 6:30898159-30898159	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.8C>T; p.P3L; 6:30888737-30888737	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.887G>A; p.R296H; 6:30892330-30892330	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.700G>A; p.G234S; 6:30892036-30892036	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2112A>G; p.P704P; 6:30898079-30898079	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2152C>T; p.R718C; 6:30898119-30898119	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.993C>T; p.A331A; 6:30892436-30892436	skin	malignant_melanoma	Substitution - coding silent
c.1196-1G>A; p.?; 6:30893271-30893271	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1755G>T; p.G585G; 6:30896862-30896862	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.107G>A; p.G36D; 6:30888929-30888929	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.130G>T; p.D44Y; 6:30888952-30888952	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1248C>T; p.T416T; 6:30893324-30893324	bone; humerus	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2302C>T; p.L768L; 6:30898269-30898269	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2472_2473CC>TT; p.R825W; 6:30899019-30899020	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2472_2473CC>TT; p.R825W; 6:30899019-30899020	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2590C>T; p.L864L; 6:30899255-30899255	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.711G>T; p.G237G; 6:30892047-30892047	breast	carcinoma	Substitution - coding silent
c.1797T>C; p.V599V; 6:30897052-30897052	prostate	adenoma	Substitution - coding silent
c.1797T>C; p.V599V; 6:30897052-30897052	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2488C>T; p.Q830*; 6:30899035-30899035	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1365G>A; p.L455L; 6:30894523-30894523	stomach	adenocarcinoma	Substitution - coding silent
c.1081G>A; p.E361K; 6:30892524-30892524	skin	malignant_melanoma	Substitution - Missense
c.307C>A; p.Q103K; 6:30889320-30889320	skin	malignant_melanoma	Substitution - Missense
c.1663delC; p.P556fs*60; 6:30896770-30896770	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.271C>G; p.L91V; 6:30889284-30889284	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1655C>A; p.P552H; 6:30896762-30896762	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2143T>C; p.S715P; 6:30898110-30898110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1260C>T; p.I420I; 6:30893336-30893336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2460G>A; p.A820A; 6:30899007-30899007	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.466delG; p.M159fs*16; 6:30891021-30891021	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.2087C>T; p.A696V; 6:30897579-30897579	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.640A>C; p.T214P; 6:30891454-30891454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.701G>A; p.G234D; 6:30892037-30892037	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1934C>A; p.P645Q; 6:30897426-30897426	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1940T>C; p.I647T; 6:30897432-30897432	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2519C>T; p.P840L; 6:30899184-30899184	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1914C>T; p.I638I; 6:30897406-30897406	skin	malignant_melanoma	Substitution - coding silent
c.743G>T; p.R248L; 6:30892079-30892079	skin	malignant_melanoma	Substitution - Missense
c.1662_1663insC; p.G557fs*35; 6:30896769-30896770	lung	carcinoma; small_cell_carcinoma	Insertion - Frameshift
c.630C>G; p.L210L; 6:30891444-30891444	ovary	other; neoplasm	Substitution - coding silent
c.343T>A; p.S115T; 6:30889356-30889356	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1438G>A; p.E480K; 6:30894596-30894596	breast	carcinoma	Substitution - Missense
c.2558G>A; p.R853Q; 6:30899223-30899223	prostate	carcinoma	Substitution - Missense
c.658G>A; p.V220M; 6:30891472-30891472	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1705C>T; p.P569S; 6:30896812-30896812	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1074C>T; p.L358L; 6:30892517-30892517	skin	malignant_melanoma	Substitution - coding silent
c.1489G>T; p.A497S; 6:30894647-30894647	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1489G>T; p.A497S; 6:30894647-30894647	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2297C>T; p.A766V; 6:30898264-30898264	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1487C>T; p.S496F; 6:30894645-30894645	skin	malignant_melanoma	Substitution - Missense
c.1297A>G; p.I433V; 6:30893373-30893373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1297A>G; p.I433V; 6:30893373-30893373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.243C>T; p.P81P; 6:30889256-30889256	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1297A>G; p.I433V; 6:30893373-30893373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.176C>G; p.A59G; 6:30888998-30888998	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1633delG; p.G546fs*70; 6:30896740-30896740	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.774G>T; p.W258C; 6:30892110-30892110	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1741G>C; p.E581Q; 6:30896848-30896848	breast	carcinoma	Substitution - Missense
c.1566C>T; p.P522P; 6:30896673-30896673	skin	malignant_melanoma	Substitution - coding silent
c.1574C>T; p.P525L; 6:30896681-30896681	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2408G>C; p.C803S; 6:30898955-30898955	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.511G>T; p.D171Y; 6:30891066-30891066	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2612A>T; p.D871V; 6:30899277-30899277	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.2090A>T; p.Q697L; 6:30897582-30897582	liver	carcinoma	Substitution - Missense
c.2090A>T; p.Q697L; 6:30897582-30897582	liver	carcinoma	Substitution - Missense
c.1603G>T; p.A535S; 6:30896710-30896710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1043G>C; p.C348S; 6:30892486-30892486	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.167C>T; p.S56F; 6:30888989-30888989	skin	malignant_melanoma	Substitution - Missense
c.1557G>A; p.P519P; 6:30896664-30896664	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1767G>A; p.L589L; 6:30897022-30897022	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.994C>T; p.R332W; 6:30892437-30892437	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2061delG; p.A689fs*48; 6:30897553-30897553	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.242C>T; p.P81L; 6:30889255-30889255	skin	malignant_melanoma	Substitution - Missense
c.1219C>T; p.P407S; 6:30893295-30893295	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2470T>C; p.F824L; 6:30899017-30899017	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1504delA; p.N502fs*114; 6:30894662-30894662	liver	carcinoma	Deletion - Frameshift
c.1400G>T; p.G467V; 6:30894558-30894558	skin	malignant_melanoma	Substitution - Missense
c.2599T>C; p.F867L; 6:30899264-30899264	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1956C>T; p.G652G; 6:30897448-30897448	stomach	adenocarcinoma	Substitution - coding silent
c.1709G>A; p.R570Q; 6:30896816-30896816	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1822C>T; p.R608C; 6:30897077-30897077	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1704C>T; p.F568F; 6:30896811-30896811	skin	malignant_melanoma	Substitution - coding silent
c.2600T>A; p.F867Y; 6:30899265-30899265	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1755G>A; p.G585G; 6:30896862-30896862	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1704C>T; p.F568F; 6:30896811-30896811	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1704C>T; p.F568F; 6:30896811-30896811	breast	carcinoma	Substitution - coding silent
c.1961G>A; p.C654Y; 6:30897453-30897453	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.988A>G; p.R330G; 6:30892431-30892431	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1275C>T; p.A425A; 6:30893351-30893351	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.443A>G; p.E148G; 6:30890998-30890998	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2352G>T; p.T784T; 6:30898899-30898899	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.169A>G; p.T57A; 6:30888991-30888991	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2065G>C; p.A689P; 6:30897557-30897557	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.43G>T; p.V15L; 6:30888772-30888772	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.729G>T; p.K243N; 6:30892065-30892065	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1488C>T; p.S496S; 6:30894646-30894646	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1020C>T; p.G340G; 6:30892463-30892463	skin	malignant_melanoma	Substitution - coding silent
c.1935A>C; p.P645P; 6:30897427-30897427	thyroid	other; neoplasm	Substitution - coding silent
c.493C>T; p.R165C; 6:30891048-30891048	skin	malignant_melanoma	Substitution - Missense
c.493C>T; p.R165C; 6:30891048-30891048	skin	malignant_melanoma	Substitution - Missense
c.876G>A; p.T292T; 6:30892319-30892319	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2299G>T; p.V767L; 6:30898266-30898266	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.876G>A; p.T292T; 6:30892319-30892319	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.342C>T; p.F114F; 6:30889355-30889355	skin	malignant_melanoma	Substitution - coding silent
c.2062G>C; p.G688R; 6:30897554-30897554	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2507C>T; p.P836L; 6:30899172-30899172	large_intestine; colon	NS	Substitution - Missense
c.1318C>T; p.R440W; 6:30893394-30893394	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2082G>T; p.Q694H; 6:30897574-30897574	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1299C>A; p.I433I; 6:30893375-30893375	breast	carcinoma	Substitution - coding silent
c.760G>C; p.D254H; 6:30892096-30892096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1903G>C; p.E635Q; 6:30897395-30897395	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2250G>T; p.M750I; 6:30898217-30898217	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1380G>A; p.T460T; 6:30894538-30894538	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1380G>A; p.T460T; 6:30894538-30894538	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1463G>A; p.R488Q; 6:30894621-30894621	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1463G>A; p.R488Q; 6:30894621-30894621	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.702T>C; p.G234G; 6:30892038-30892038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1449G>A; p.P483P; 6:30894607-30894607	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2088G>A; p.A696A; 6:30897580-30897580	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2601C>T; p.F867F; 6:30899266-30899266	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.136G>A; p.D46N; 6:30888958-30888958	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1402G>A; p.D468N; 6:30894560-30894560	urinary_tract; bladder	carcinoma	Substitution - Missense
c.657C>T; p.T219T; 6:30891471-30891471	liver	carcinoma	Substitution - coding silent
c.2182C>T; p.R728W; 6:30898149-30898149	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1155G>T; p.W385C; 6:30893123-30893123	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1011C>T; p.P337P; 6:30892454-30892454	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.321C>T; p.A107A; 6:30889334-30889334	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.824A>T; p.D275V; 6:30892160-30892160	liver	carcinoma	Substitution - Missense
c.423C>A; p.I141I; 6:30890978-30890978	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.824A>T; p.D275V; 6:30892160-30892160	liver	carcinoma	Substitution - Missense
c.423C>A; p.I141I; 6:30890978-30890978	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.206G>T; p.G69V; 6:30889219-30889219	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.241C>T; p.P81S; 6:30889254-30889254	skin	malignant_melanoma	Substitution - Missense
c.1332C>T; p.R444R; 6:30893408-30893408	stomach	carcinoma; adenocarcinoma	Substitution - coding silent

The somatic mutations from COSMIC database