Entrez Gene

Basic Information
Gene ID	7049
Name	TGFBR3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.2240C>T; p.T747M; 1:91708710-91708710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1321C>T; p.P441S; 1:91719985-91719985	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.956A>G; p.D319G; 1:91722074-91722074	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2300G>A; p.S767N; 1:91698118-91698118	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.216A>G; p.A72A; 1:91797317-91797317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2472C>T; p.S824S; 1:91683823-91683823	skin	malignant_melanoma	Substitution - coding silent
c.528A>G; p.E176E; 1:91734816-91734816	thyroid	carcinoma	Substitution - coding silent
c.1653G>A; p.P551P; 1:91716622-91716622	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.581C>A; p.P194H; 1:91729961-91729961	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>T; p.G56C; 1:91797367-91797367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.579C>T; p.F193F; 1:91729963-91729963	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2429C>A; p.S810Y; 1:91695680-91695680	breast	carcinoma	Substitution - Missense
c.52G>T; p.A18S; 1:91861480-91861480	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1071T>G; p.N357K; 1:91721959-91721959	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2416T>A; p.W806R; 1:91695693-91695693	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2346G>T; p.L782L; 1:91695763-91695763	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.795_796GG>AC; p.V266L; 1:91727748-91727749	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.391G>A; p.E131K; 1:91734953-91734953	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.289C>A; p.H97N; 1:91758708-91758708	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.128T>C; p.M43T; 1:91797405-91797405	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.600G>T; p.G200G; 1:91729942-91729942	skin	malignant_melanoma	Substitution - coding silent
c.2410G>T; p.A804S; 1:91695699-91695699	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2127G>T; p.L709L; 1:91712282-91712282	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.189G>T; p.E63D; 1:91797344-91797344	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1102C>A; p.H368N; 1:91720204-91720204	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1419T>C; p.S473S; 1:91719459-91719459	prostate	carcinoma	Substitution - coding silent
c.1448T>G; p.L483W; 1:91719430-91719430	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.965C>G; p.S322*; 1:91722065-91722065	ovary	other; neoplasm	Substitution - Nonsense
c.280C>T; p.H94Y; 1:91758717-91758717	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1779C>G; p.F593L; 1:91716323-91716323	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2278G>T; p.E760*; 1:91708672-91708672	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.684G>T; p.Q228H; 1:91729858-91729858	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.738T>C; p.S246S; 1:91727806-91727806	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.61+2T>C; p.?; 1:91861469-91861469	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1460G>T; p.C487F; 1:91719418-91719418	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1394_1395delTA; p.V465fs*50; 1:91719911-91719912	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.2107C>G; p.L703V; 1:91712302-91712302	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2519C>T; p.T840M; 1:91683776-91683776	prostate	adenoma	Substitution - Missense
c.1387G>A; p.V463M; 1:91719919-91719919	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1781A>T; p.N594I; 1:91716321-91716321	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.538G>A; p.A180T; 1:91734806-91734806	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.232C>T; p.Q78*; 1:91797301-91797301	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.280C>A; p.H94N; 1:91758717-91758717	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1821C>T; p.S607S; 1:91716281-91716281	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1368T>A; p.C456*; 1:91719938-91719938	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1054C>T; p.H352Y; 1:91721976-91721976	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2537C>A; p.S846Y; 1:91683758-91683758	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.413C>A; p.S138*; 1:91734931-91734931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1480A>G; p.T494A; 1:91719398-91719398	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.854C>A; p.S285Y; 1:91727690-91727690	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.107C>T; p.S36F; 1:91797426-91797426	skin	malignant_melanoma	Substitution - Missense
c.854C>A; p.S285Y; 1:91727690-91727690	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1268G>A; p.R423Q; 1:91720038-91720038	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2527A>T; p.T843S; 1:91683768-91683768	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1616G>C; p.G539A; 1:91716659-91716659	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1377G>A; p.E459E; 1:91719929-91719929	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.702C>T; p.I234I; 1:91729840-91729840	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.531C>A; p.L177L; 1:91734813-91734813	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2320A>T; p.I774F; 1:91698098-91698098	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1210C>T; p.P404S; 1:91720096-91720096	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1411C>T; p.Q471*; 1:91719895-91719895	skin	malignant_melanoma	Substitution - Nonsense
c.293A>C; p.K98T; 1:91758704-91758704	breast	carcinoma	Substitution - Missense
c.1934C>T; p.S645L; 1:91712475-91712475	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1211C>T; p.P404L; 1:91720095-91720095	skin	malignant_melanoma	Substitution - Missense
c.526G>A; p.E176K; 1:91734818-91734818	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2133G>A; p.T711T; 1:91712276-91712276	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1401delA; p.D468fs*24; 1:91719905-91719905	liver	carcinoma	Deletion - Frameshift
c.494G>A; p.R165Q; 1:91734850-91734850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1394T>G; p.V465G; 1:91719912-91719912	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.494G>A; p.R165Q; 1:91734850-91734850	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1196G>C; p.G399A; 1:91720110-91720110	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1946G>T; p.R649M; 1:91712463-91712463	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2156A>G; p.K719R; 1:91712253-91712253	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.787C>G; p.L263V; 1:91727757-91727757	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2202C>T; p.D734D; 1:91708748-91708748	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.583C>G; p.P195A; 1:91729959-91729959	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1690C>T; p.R564*; 1:91716585-91716585	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Nonsense
c.531C>T; p.L177L; 1:91734813-91734813	oesophagus	carcinoma	Substitution - coding silent
c.1690C>T; p.R564*; 1:91716585-91716585	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Nonsense
c.1935G>A; p.S645S; 1:91712474-91712474	skin	malignant_melanoma	Substitution - coding silent
c.1293C>T; p.S431S; 1:91720013-91720013	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1246G>A; p.E416K; 1:91720060-91720060	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1942G>A; p.D648N; 1:91712467-91712467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1123C>T; p.R375W; 1:91720183-91720183	stomach	adenocarcinoma	Substitution - Missense
c.1708-1G>C; p.?; 1:91716395-91716395	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.1264C>T; p.P422S; 1:91720042-91720042	skin	malignant_melanoma	Substitution - Missense
c.333G>A; p.V111V; 1:91758664-91758664	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.333G>A; p.V111V; 1:91758664-91758664	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1680C>T; p.S560S; 1:91716595-91716595	skin	malignant_melanoma	Substitution - coding silent
c.1414-2A>T; p.?; 1:91719466-91719466	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.1025A>C; p.Y342S; 1:91722005-91722005	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1838T>C; p.V613A; 1:91716264-91716264	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.977A>G; p.N326S; 1:91722053-91722053	prostate	carcinoma	Substitution - Missense
c.2028T>C; p.F676F; 1:91712381-91712381	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.2511C>T; p.I837I; 1:91683784-91683784	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2028T>C; p.F676F; 1:91712381-91712381	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2028T>C; p.F676F; 1:91712381-91712381	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2028T>C; p.F676F; 1:91712381-91712381	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1427C>T; p.S476L; 1:91719451-91719451	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1428G>A; p.S476S; 1:91719450-91719450	breast	carcinoma	Substitution - coding silent
c.1519A>G; p.T507A; 1:91719359-91719359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.671C>G; p.S224C; 1:91729871-91729871	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1522C>T; p.R508W; 1:91719356-91719356	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1719C>T; p.S573S; 1:91716383-91716383	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.158C>T; p.A53V; 1:91797375-91797375	thyroid	carcinoma	Substitution - Missense
c.578T>C; p.F193S; 1:91729964-91729964	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2386G>C; p.V796L; 1:91695723-91695723	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1849G>A; p.G617R; 1:91716253-91716253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1672G>A; p.D558N; 1:91716603-91716603	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1205C>T; p.P402L; 1:91720101-91720101	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1806C>T; p.L602L; 1:91716296-91716296	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1904C>T; p.A635V; 1:91712505-91712505	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1060C>T; p.R354W; 1:91721970-91721970	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1049G>T; p.R350I; 1:91721981-91721981	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2076C>A; p.F692L; 1:91712333-91712333	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.872G>A; p.S291N; 1:91727672-91727672	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.23C>T; p.A8V; 1:91861509-91861509	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.90G>C; p.L30L; 1:91797443-91797443	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1438G>A; p.V480I; 1:91719440-91719440	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.282C>A; p.H94Q; 1:91758715-91758715	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1280C>T; p.P427L; 1:91720026-91720026	skin	malignant_melanoma	Substitution - Missense
c.391G>C; p.E131Q; 1:91734953-91734953	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.603G>T; p.K201N; 1:91729939-91729939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1773C>T; p.I591I; 1:91716329-91716329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2012C>T; p.P671L; 1:91712397-91712397	skin	malignant_melanoma	Substitution - Missense
c.1938C>T; p.N646N; 1:91712471-91712471	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2396C>T; p.A799V; 1:91695713-91695713	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.463C>A; p.H155N; 1:91734881-91734881	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2418G>A; p.W806*; 1:91695691-91695691	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1686C>T; p.F562F; 1:91716589-91716589	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2300G>C; p.S767T; 1:91698118-91698118	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2064C>T; p.F688F; 1:91712345-91712345	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1469A>C; p.K490T; 1:91719409-91719409	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1663G>A; p.D555N; 1:91716612-91716612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.635A>G; p.Y212C; 1:91729907-91729907	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.635A>G; p.Y212C; 1:91729907-91729907	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2495G>A; p.S832N; 1:91683800-91683800	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.317C>T; p.S106F; 1:91758680-91758680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.317C>T; p.S106F; 1:91758680-91758680	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2066G>A; p.S689N; 1:91712343-91712343	breast	carcinoma	Substitution - Missense
c.1942G>C; p.D648H; 1:91712467-91712467	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1869A>G; p.V623V; 1:91712540-91712540	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2169T>C; p.C723C; 1:91708781-91708781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.542G>T; p.R181I; 1:91734802-91734802	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.542G>T; p.R181I; 1:91734802-91734802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1100T>C; p.V367A; 1:91720206-91720206	breast	carcinoma	Substitution - Missense
c.2392G>A; p.G798R; 1:91695717-91695717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.96T>A; p.P32P; 1:91797437-91797437	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1036C>T; p.P346S; 1:91721994-91721994	skin	malignant_melanoma	Substitution - Missense
c.2214C>A; p.I738I; 1:91708736-91708736	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1708-5_1708-4insT; p.?; 1:91716398-91716399	liver	carcinoma	Unknown
c.1402G>T; p.D468Y; 1:91719904-91719904	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2483C>G; p.S828W; 1:91683812-91683812	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2004C>A; p.F668L; 1:91712405-91712405	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2181C>T; p.D727D; 1:91708769-91708769	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.360C>A; p.A120A; 1:91758637-91758637	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206G>A; p.P402P; 1:91720100-91720100	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1206G>A; p.P402P; 1:91720100-91720100	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.44C>T; p.S15F; 1:91861488-91861488	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1691G>A; p.R564Q; 1:91716584-91716584	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.44C>T; p.S15F; 1:91861488-91861488	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.44C>T; p.S15F; 1:91861488-91861488	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.598G>A; p.G200R; 1:91729944-91729944	skin	malignant_melanoma	Substitution - Missense
c.2413T>C; p.L805L; 1:91695696-91695696	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.869G>A; p.G290E; 1:91727675-91727675	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2149C>T; p.P717S; 1:91712260-91712260	skin	malignant_melanoma	Substitution - Missense
c.428C>T; p.S143F; 1:91734916-91734916	skin	malignant_melanoma	Substitution - Missense
c.886-3C>T; p.?; 1:91722147-91722147	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown

The somatic mutations from COSMIC database