Entrez Gene

Basic Information
Gene ID	6695
Name	SPOCK1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.706A>G; p.R236G; 5:136992484-136992484	skin	malignant_melanoma	Substitution - Missense
c.1056G>T; p.T352T; 5:136979405-136979405	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.870C>T; p.S290S; 5:136988480-136988480	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.655G>A; p.E219K; 5:136992535-136992535	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1258G>A; p.V420M; 5:136978716-136978716	pancreas	carcinoma	Substitution - Missense
c.367G>T; p.A123S; 5:137112542-137112542	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.655G>A; p.E219K; 5:136992535-136992535	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.655G>A; p.E219K; 5:136992535-136992535	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1258G>A; p.V420M; 5:136978716-136978716	pancreas	carcinoma	Substitution - Missense
c.1258G>A; p.V420M; 5:136978716-136978716	breast	carcinoma	Substitution - Missense
c.1258G>A; p.V420M; 5:136978716-136978716	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.75C>T; p.D25D; 5:137498484-137498484	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.598G>C; p.D200H; 5:136992592-136992592	liver	carcinoma	Substitution - Missense
c.598G>C; p.D200H; 5:136992592-136992592	liver	carcinoma	Substitution - Missense
c.827A>C; p.K276T; 5:136988523-136988523	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.49C>T; p.L17F; 5:137498510-137498510	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.419C>T; p.P140L; 5:137112490-137112490	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.419C>T; p.P140L; 5:137112490-137112490	skin	malignant_melanoma	Substitution - Missense
c.1039C>A; p.Q347K; 5:136979422-136979422	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.527G>A; p.C176Y; 5:137067777-137067777	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.419C>T; p.P140L; 5:137112490-137112490	skin	malignant_melanoma	Substitution - Missense
c.602A>G; p.K201R; 5:136992588-136992588	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.81C>G; p.L27L; 5:137498478-137498478	liver	carcinoma	Substitution - coding silent
c.81C>G; p.L27L; 5:137498478-137498478	liver	carcinoma	Substitution - coding silent
c.594C>T; p.C198C; 5:136992596-136992596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.259C>A; p.L87M; 5:137140668-137140668	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.316C>A; p.L106M; 5:137140611-137140611	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1044C>T; p.C348C; 5:136979417-136979417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1125C>G; p.S375R; 5:136979336-136979336	ovary	other; neoplasm	Substitution - Missense
c.84C>T; p.A28A; 5:137498475-137498475	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1252C>G; p.R418G; 5:136978722-136978722	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1121T>C; p.V374A; 5:136979340-136979340	breast	carcinoma	Substitution - Missense
c.461C>A; p.S154Y; 5:137112448-137112448	NS	malignant_melanoma	Substitution - Missense
c.461C>A; p.S154Y; 5:137112448-137112448	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.421G>A; p.V141M; 5:137112488-137112488	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.101A>G; p.N34S; 5:137498458-137498458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.933C>T; p.L311L; 5:136985198-136985198	breast	carcinoma	Substitution - coding silent
c.843C>T; p.I281I; 5:136988507-136988507	skin	malignant_melanoma	Substitution - coding silent
c.598G>T; p.D200Y; 5:136992592-136992592	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.856A>T; p.N286Y; 5:136988494-136988494	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.822G>A; p.L274L; 5:136988528-136988528	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.187-1G>T; p.?; 5:137267056-137267056	stomach	carcinoma; adenocarcinoma	Unknown
c.187-1G>T; p.?; 5:137267056-137267056	lung	carcinoma; adenocarcinoma	Unknown
c.412C>T; p.P138S; 5:137112497-137112497	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.868T>A; p.S290T; 5:136988482-136988482	liver	carcinoma	Substitution - Missense
c.868T>A; p.S290T; 5:136988482-136988482	liver	carcinoma	Substitution - Missense
c.831C>G; p.Y277*; 5:136988519-136988519	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Nonsense
c.610C>T; p.R204W; 5:136992580-136992580	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.610C>T; p.R204W; 5:136992580-136992580	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.296C>T; p.T99I; 5:137140631-137140631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1212G>T; p.L404L; 5:136978762-136978762	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.625C>T; p.R209W; 5:136992565-136992565	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.625C>T; p.R209W; 5:136992565-136992565	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.625C>T; p.R209W; 5:136992565-136992565	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.142G>A; p.V48I; 5:137498417-137498417	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.142G>A; p.V48I; 5:137498417-137498417	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.955A>T; p.R319*; 5:136985176-136985176	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.329G>A; p.R110H; 5:137140598-137140598	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.206G>A; p.W69*; 5:137267036-137267036	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.189T>G; p.D63E; 5:137267053-137267053	skin	malignant_melanoma	Substitution - Missense
c.212C>T; p.P71L; 5:137267030-137267030	skin	malignant_melanoma	Substitution - Missense
c.1170G>T; p.G390G; 5:136978804-136978804	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.516C>T; p.L172L; 5:137067788-137067788	breast	carcinoma	Substitution - coding silent
c.516C>T; p.L172L; 5:137067788-137067788	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.723C>A; p.I241I; 5:136988627-136988627	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.31G>A; p.A11T; 5:137498528-137498528	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.827A>T; p.K276M; 5:136988523-136988523	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>T; p.Q100H; 5:137140627-137140627	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.705C>T; p.G235G; 5:136992485-136992485	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1253G>A; p.R418Q; 5:136978721-136978721	skin	malignant_melanoma	Substitution - Missense
c.970A>T; p.S324C; 5:136985161-136985161	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.644G>A; p.G215E; 5:136992546-136992546	skin	malignant_melanoma	Substitution - Missense
c.1003C>T; p.P335S; 5:136979458-136979458	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.369C>A; p.A123A; 5:137112540-137112540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.591C>T; p.A197A; 5:136992599-136992599	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.893A>C; p.N298T; 5:136988457-136988457	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.520A>T; p.T174S; 5:137067784-137067784	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.298C>T; p.Q100*; 5:137140629-137140629	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.415T>G; p.C139G; 5:137112494-137112494	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.490C>G; p.H164D; 5:137067814-137067814	breast	carcinoma	Substitution - Missense
c.177C>T; p.R59R; 5:137498382-137498382	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.513C>G; p.S171R; 5:137067791-137067791	pancreas	carcinoma	Substitution - Missense
c.1117G>A; p.A373T; 5:136979344-136979344	breast	carcinoma	Substitution - Missense
c.750C>A; p.G250G; 5:136988600-136988600	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.626G>A; p.R209Q; 5:136992564-136992564	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.626G>A; p.R209Q; 5:136992564-136992564	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.976G>A; p.G326R; 5:136985155-136985155	skin	malignant_melanoma	Substitution - Missense
c.766T>C; p.L256L; 5:136988584-136988584	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.601A>C; p.K201Q; 5:136992589-136992589	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.542C>T; p.P181L; 5:137067762-137067762	skin	malignant_melanoma	Substitution - Missense
c.1276G>C; p.D426H; 5:136978698-136978698	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.393G>A; p.S131S; 5:137112516-137112516	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.393G>A; p.S131S; 5:137112516-137112516	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.393G>A; p.S131S; 5:137112516-137112516	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.393G>A; p.S131S; 5:137112516-137112516	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.393G>A; p.S131S; 5:137112516-137112516	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.423G>T; p.V141V; 5:137112486-137112486	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.893A>G; p.N298S; 5:136988457-136988457	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.341T>C; p.L114P; 5:137140586-137140586	skin	malignant_melanoma	Substitution - Missense
c.881G>A; p.G294D; 5:136988469-136988469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1184_1185TG>TC; p.L395>?; 5:136978789-136978790	lung	carcinoma; adenocarcinoma	Complex
c.774G>A; p.M258I; 5:136988576-136988576	skin	malignant_melanoma	Substitution - Missense
c.106G>T; p.G36C; 5:137498453-137498453	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.517G>A; p.A173T; 5:137067787-137067787	prostate	carcinoma	Substitution - Missense
c.556C>T; p.P186S; 5:137067748-137067748	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1257C>T; p.A419A; 5:136978717-136978717	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>C; p.V392V; 5:136978798-136978798	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.590C>A; p.A197D; 5:136992600-136992600	breast	carcinoma	Substitution - Missense
c.1138C>T; p.Q380*; 5:136978836-136978836	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1269_1274delTGATGA; p.D423_D424delDD; 5:136978700-136978705	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - In frame
c.605A>C; p.E202A; 5:136992585-136992585	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.749delG; p.G250fs*9; 5:136988601-136988601	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.611G>A; p.R204Q; 5:136992579-136992579	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.611G>A; p.R204Q; 5:136992579-136992579	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1153G>T; p.D385Y; 5:136978821-136978821	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.884A>C; p.K295T; 5:136988466-136988466	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1217delC; p.P406fs*8; 5:136978757-136978757	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.419_420CC>TT; p.P140L; 5:137112489-137112490	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.929-3delT; p.?; 5:136985205-136985205	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.793G>C; p.D265H; 5:136988557-136988557	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1280A>T; p.E427V; 5:136978694-136978694	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1205G>A; p.R402Q; 5:136978769-136978769	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.776A>C; p.N259T; 5:136988574-136988574	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.313G>A; p.A105T; 5:137140614-137140614	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.700C>T; p.Q234*; 5:136992490-136992490	skin	malignant_melanoma	Substitution - Nonsense
c.85G>A; p.G29R; 5:137498474-137498474	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.735C>A; p.C245*; 5:136988615-136988615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.535C>T; p.P179S; 5:137067769-137067769	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1305C>T; p.V435V; 5:136978669-136978669	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent

The somatic mutations from COSMIC database