Entrez Gene

Basic Information
Gene ID	60529
Name	ALX4

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.578G>A; p.R193Q; 11:44275547-44275547	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.480C>T; p.S160S; 11:44275645-44275645	skin	malignant_melanoma	Substitution - coding silent
c.190G>A; p.A64T; 11:44309873-44309873	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>T; p.H363Y; 11:44265003-44265003	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>T; p.H363Y; 11:44265003-44265003	large_intestine; colon	carcinoma	Substitution - Missense
c.1087C>T; p.H363Y; 11:44265003-44265003	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1213G>A; p.A405T; 11:44264877-44264877	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	thyroid	other; neoplasm	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	thyroid	other; neoplasm	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>T; p.P102S; 11:44309759-44309759	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.777+1G>A; p.?; 11:44275347-44275347	lung	carcinoma; adenocarcinoma	Unknown
c.624G>T; p.E208D; 11:44275501-44275501	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.295C>T; p.P99S; 11:44309768-44309768	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1182G>A; p.A394A; 11:44264908-44264908	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.720C>T; p.D240D; 11:44275405-44275405	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.660C>T; p.T220T; 11:44275465-44275465	skin	malignant_melanoma	Substitution - coding silent
c.682G>A; p.E228K; 11:44275443-44275443	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.826G>C; p.G276R; 11:44267574-44267574	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.509C>T; p.S170F; 11:44275616-44275616	skin	malignant_melanoma	Substitution - Missense
c.615C>T; p.A205A; 11:44275510-44275510	skin	malignant_melanoma	Substitution - coding silent
c.621A>G; p.S207S; 11:44275504-44275504	thyroid	other; neoplasm	Substitution - coding silent
c.915C>A; p.N305K; 11:44265175-44265175	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.616G>A; p.D206N; 11:44275509-44275509	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1123C>T; p.P375S; 11:44264967-44264967	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.918G>A; p.P306P; 11:44265172-44265172	prostate	carcinoma	Substitution - coding silent
c.1025G>C; p.G342A; 11:44265065-44265065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.R216W; 11:44275479-44275479	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.R216W; 11:44275479-44275479	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.927C>A; p.L309L; 11:44265163-44265163	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.700C>T; p.Q234*; 11:44275425-44275425	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1017_1018insC; p.G340fs*>73; 11:44265072-44265073	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.772G>A; p.V258M; 11:44275353-44275353	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.772G>A; p.V258M; 11:44275353-44275353	breast	carcinoma	Substitution - Missense
c.1059T>G; p.S353S; 11:44265031-44265031	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.770G>A; p.R257H; 11:44275355-44275355	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.817G>T; p.E273*; 11:44267583-44267583	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.522G>T; p.G174G; 11:44275603-44275603	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.178G>A; p.A60T; 11:44309885-44309885	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1013C>T; p.P338L; 11:44265077-44265077	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.377G>A; p.R126Q; 11:44309686-44309686	urinary_tract; bladder	carcinoma	Substitution - Missense
c.377G>A; p.R126Q; 11:44309686-44309686	urinary_tract; bladder	carcinoma	Substitution - Missense
c.638A>G; p.K213R; 11:44275487-44275487	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.998C>T; p.S333F; 11:44265092-44265092	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.877C>T; p.L293F; 11:44267523-44267523	skin	malignant_melanoma	Substitution - Missense
c.538C>A; p.L180M; 11:44275587-44275587	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.471A>C; p.K157N; 11:44275654-44275654	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1149C>T; p.N383N; 11:44264941-44264941	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.86A>G; p.E29G; 11:44309977-44309977	liver	carcinoma	Substitution - Missense
c.886C>T; p.R296*; 11:44267514-44267514	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.381C>T; p.G127G; 11:44309682-44309682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.886C>T; p.R296*; 11:44267514-44267514	breast	carcinoma	Substitution - Nonsense
c.549G>A; p.K183K; 11:44275576-44275576	skin	malignant_melanoma	Substitution - coding silent
c.129C>T; p.F43F; 11:44309934-44309934	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.129C>T; p.F43F; 11:44309934-44309934	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.887G>A; p.R296Q; 11:44267513-44267513	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.69G>C; p.P23P; 11:44309994-44309994	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.569C>T; p.P190L; 11:44275556-44275556	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.351C>A; p.P117P; 11:44309712-44309712	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.443C>T; p.A148V; 11:44309620-44309620	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.79A>T; p.S27C; 11:44309984-44309984	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1028C>T; p.A343V; 11:44265062-44265062	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.781T>C; p.W261R; 11:44267619-44267619	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.79A>T; p.S27C; 11:44309984-44309984	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1009C>T; p.H337Y; 11:44265081-44265081	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.731G>A; p.R244Q; 11:44275394-44275394	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.793C>T; p.R265*; 11:44267607-44267607	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.500C>A; p.P167H; 11:44275625-44275625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.500C>A; p.P167H; 11:44275625-44275625	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecified	Substitution - Missense
c.188G>A; p.R63Q; 11:44309875-44309875	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.819G>A; p.E273E; 11:44267581-44267581	breast	carcinoma	Substitution - coding silent
c.964G>A; p.V322M; 11:44265126-44265126	liver	carcinoma	Substitution - Missense
c.664A>G; p.T222A; 11:44275461-44275461	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1026G>C; p.G342G; 11:44265064-44265064	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.794G>A; p.R265Q; 11:44267606-44267606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.794G>A; p.R265Q; 11:44267606-44267606	breast	carcinoma	Substitution - Missense
c.776A>T; p.Q259L; 11:44275349-44275349	liver	carcinoma	Substitution - Missense
c.776A>T; p.Q259L; 11:44275349-44275349	liver	carcinoma	Substitution - Missense
c.821G>A; p.R274H; 11:44267579-44267579	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.814C>T; p.R272W; 11:44267586-44267586	liver	carcinoma	Substitution - Missense
c.814C>T; p.R272W; 11:44267586-44267586	liver	carcinoma	Substitution - Missense
c.949C>A; p.P317T; 11:44265141-44265141	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.83G>A; p.R28Q; 11:44309980-44309980	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.643C>G; p.R215G; 11:44275482-44275482	lung	carcinoid-endocrine_tumour; typical	Substitution - Missense
c.441C>T; p.S147S; 11:44309622-44309622	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.503delC; p.P168fs*13; 11:44275622-44275622	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.503delC; p.P168fs*13; 11:44275622-44275622	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.522G>A; p.G174G; 11:44275603-44275603	breast	carcinoma	Substitution - coding silent
c.728C>A; p.A243E; 11:44275397-44275397	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.613G>A; p.A205T; 11:44275512-44275512	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.708C>G; p.T236T; 11:44275417-44275417	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.402C>T; p.D134D; 11:44309661-44309661	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.104G>C; p.R35T; 11:44309959-44309959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.104G>C; p.R35T; 11:44309959-44309959	thyroid	other; neoplasm	Substitution - Missense
c.955C>A; p.P319T; 11:44265135-44265135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1091T>C; p.M364T; 11:44264999-44264999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.820C>A; p.R274S; 11:44267580-44267580	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.950C>A; p.P317Q; 11:44265140-44265140	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.917C>T; p.P306L; 11:44265173-44265173	skin	malignant_melanoma	Substitution - Missense
c.917C>T; p.P306L; 11:44265173-44265173	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1074C>T; p.H358H; 11:44265016-44265016	prostate	adenoma	Substitution - coding silent
c.1074C>T; p.H358H; 11:44265016-44265016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1158G>A; p.P386P; 11:44264932-44264932	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.106G>A; p.A36T; 11:44309957-44309957	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.845G>A; p.R282Q; 11:44267555-44267555	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.812_813insA; p.R272fs*19; 11:44267587-44267588	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1214C>T; p.A405V; 11:44264876-44264876	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.652C>T; p.R218W; 11:44275473-44275473	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.729G>A; p.A243A; 11:44275396-44275396	thyroid	other; neoplasm	Substitution - coding silent
c.729G>A; p.A243A; 11:44275396-44275396	thyroid	other; neoplasm	Substitution - coding silent
c.1123C>A; p.P375T; 11:44264967-44264967	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2T>C; p.M1T; 11:44310061-44310061	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.38C>T; p.P13L; 11:44310025-44310025	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.889G>A; p.A297T; 11:44267511-44267511	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1150G>A; p.G384S; 11:44264940-44264940	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1190G>A; p.R397H; 11:44264900-44264900	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.681G>T; p.E227D; 11:44275444-44275444	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1016delC; p.P339fs*12; 11:44265074-44265074	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.570C>T; p.P190P; 11:44275555-44275555	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1141G>A; p.E381K; 11:44264949-44264949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.653G>A; p.R218Q; 11:44275472-44275472	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.653G>A; p.R218Q; 11:44275472-44275472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.844C>T; p.R282*; 11:44267556-44267556	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.860C>A; p.T287N; 11:44267540-44267540	lung	carcinoma; small_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database