Entrez Gene

Basic Information
Gene ID	56649
Name	TMPRSS4

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.585C>T; p.A195A; 11:118111742-118111742	skin	malignant_melanoma	Substitution - coding silent
c.750T>C; p.H250H; 11:118113275-118113275	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1238C>A; p.P413Q; 11:118117390-118117390	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1283G>A; p.W428*; 11:118117435-118117435	skin	malignant_melanoma	Substitution - Nonsense
c.357C>T; p.A119A; 11:118104737-118104737	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1038G>A; p.A346A; 11:118115166-118115166	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.157+1G>T; p.?; 11:118099099-118099099	lung	carcinoma; adenocarcinoma	Unknown
c.1038G>A; p.A346A; 11:118115166-118115166	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.42C>T; p.L14L; 11:118094854-118094854	skin	malignant_melanoma	Substitution - coding silent
c.55C>A; p.L19M; 11:118098996-118098996	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1140G>A; p.V380V; 11:118115268-118115268	skin	malignant_melanoma	Substitution - coding silent
c.1120G>T; p.G374C; 11:118115248-118115248	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1234G>A; p.G412S; 11:118117386-118117386	prostate	carcinoma	Substitution - Missense
c.630G>T; p.E210D; 11:118111787-118111787	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.673G>A; p.D225N; 11:118111830-118111830	breast	carcinoma	Substitution - Missense
c.968C>G; p.P323R; 11:118114886-118114886	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.296G>A; p.G99E; 11:118103239-118103239	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.673G>A; p.D225N; 11:118111830-118111830	skin	malignant_melanoma	Substitution - Missense
c.877C>G; p.L293V; 11:118113402-118113402	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1152+1G>T; p.?; 11:118115281-118115281	lung	carcinoma; adenocarcinoma	Unknown
c.1059C>T; p.S353S; 11:118115187-118115187	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1010G>A; p.G337E; 11:118115138-118115138	skin	malignant_melanoma	Substitution - Missense
c.531G>A; p.R177R; 11:118107864-118107864	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.995C>T; p.T332M; 11:118114913-118114913	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.58C>T; p.R20C; 11:118098999-118098999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1215T>C; p.S405S; 11:118117367-118117367	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.361G>T; p.G121W; 11:118104741-118104741	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>T; p.P72S; 11:118103157-118103157	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1083G>A; p.A361A; 11:118115211-118115211	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.775C>T; p.R259W; 11:118113300-118113300	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1083G>A; p.A361A; 11:118115211-118115211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1063C>T; p.R355W; 11:118115191-118115191	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1144A>T; p.T382S; 11:118115272-118115272	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.813G>T; p.L271L; 11:118113338-118113338	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1001A>T; p.Q334L; 11:118114919-118114919	pleura	pulmonary_blastoma	Substitution - Missense
c.638T>C; p.V213A; 11:118111795-118111795	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.43G>T; p.D15Y; 11:118094855-118094855	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.73C>T; p.P25S; 11:118099014-118099014	skin	malignant_melanoma	Substitution - Missense
c.1233G>T; p.G411G; 11:118117385-118117385	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.1186G>A; p.D396N; 11:118117338-118117338	breast	carcinoma	Substitution - Missense
c.111C>T; p.I37I; 11:118099052-118099052	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1052T>C; p.I351T; 11:118115180-118115180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.657G>T; p.Q219H; 11:118111814-118111814	breast	carcinoma	Substitution - Missense
c.8A>G; p.Q3R; 11:118094820-118094820	liver	carcinoma	Substitution - Missense
c.8A>G; p.Q3R; 11:118094820-118094820	liver	carcinoma	Substitution - Missense
c.405C>T; p.L135L; 11:118104785-118104785	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.251C>T; p.P84L; 11:118103194-118103194	skin	malignant_melanoma	Substitution - Missense
c.605delC; p.R204fs*91; 11:118111762-118111762	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.50A>G; p.K17R; 11:118098991-118098991	skin	malignant_melanoma	Substitution - Missense
c.628G>A; p.E210K; 11:118111785-118111785	skin	malignant_melanoma	Substitution - Missense
c.10G>A; p.D4N; 11:118094822-118094822	skin	malignant_melanoma	Substitution - Missense
c.996G>A; p.T332T; 11:118114914-118114914	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.10G>A; p.D4N; 11:118094822-118094822	skin	malignant_melanoma	Substitution - Missense
c.292G>A; p.E98K; 11:118103235-118103235	skin	malignant_melanoma	Substitution - Missense
c.292G>A; p.E98K; 11:118103235-118103235	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1101C>T; p.T367T; 11:118115229-118115229	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.314G>A; p.R105H; 11:118104694-118104694	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.755A>T; p.D252V; 11:118113280-118113280	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.268G>A; p.E90K; 11:118103211-118103211	skin	malignant_melanoma	Substitution - Missense
c.65C>T; p.P22L; 11:118099006-118099006	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1239G>A; p.P413P; 11:118117391-118117391	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.765C>G; p.N255K; 11:118113290-118113290	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1247C>T; p.P416L; 11:118117399-118117399	skin	malignant_melanoma	Substitution - Missense
c.192C>T; p.C64C; 11:118103135-118103135	ovary	other; neoplasm	Substitution - coding silent
c.523C>T; p.R175C; 11:118107856-118107856	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.192C>T; p.C64C; 11:118103135-118103135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.523C>T; p.R175C; 11:118107856-118107856	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.192C>T; p.C64C; 11:118103135-118103135	ovary	other; neoplasm	Substitution - coding silent
c.9G>A; p.Q3Q; 11:118094821-118094821	skin	malignant_melanoma	Substitution - coding silent
c.192C>T; p.C64C; 11:118103135-118103135	ovary	other; neoplasm	Substitution - coding silent
c.523C>T; p.R175C; 11:118107856-118107856	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.523C>T; p.R175C; 11:118107856-118107856	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.920G>T; p.R307M; 11:118114838-118114838	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.920G>T; p.R307M; 11:118114838-118114838	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.204C>G; p.L68L; 11:118103147-118103147	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1077C>T; p.D359D; 11:118115205-118115205	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1011G>A; p.G337G; 11:118115139-118115139	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1230C>T; p.C410C; 11:118117382-118117382	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.384C>T; p.F128F; 11:118104764-118104764	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.779C>T; p.A260V; 11:118113304-118113304	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.384C>T; p.F128F; 11:118104764-118104764	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.13C>T; p.P5S; 11:118094825-118094825	skin	malignant_melanoma	Substitution - Missense
c.94G>A; p.V32M; 11:118099035-118099035	skin	malignant_melanoma	Substitution - Missense
c.1177T>C; p.Y393H; 11:118117329-118117329	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.130G>C; p.A44P; 11:118099071-118099071	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.517G>A; p.E173K; 11:118107850-118107850	skin; leg	malignant_melanoma; nodular	Substitution - Missense
c.936_938delCTT; p.F314delF; 11:118114854-118114856	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.210C>T; p.F70F; 11:118103153-118103153	skin	malignant_melanoma	Substitution - coding silent
c.909A>G; p.S303S; 11:118113434-118113434	thyroid	carcinoma	Substitution - coding silent
c.809_810CC>AT; p.S270Y; 11:118113334-118113335	skin	malignant_melanoma	Substitution - Missense
c.4-1A>G; p.?; 11:118094815-118094815	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.611G>A; p.R204H; 11:118111768-118111768	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database