Entrez Gene

Basic Information
Gene ID	54910
Name	SEMA4C

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.159C>T; p.F53F; 2:96866382-96866382	skin	malignant_melanoma	Substitution - coding silent
c.274C>T; p.P92S; 2:96865914-96865914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1759C>T; p.R587C; 2:96861369-96861369	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.125T>A; p.V42E; 2:96866416-96866416	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.266G>T; p.W89L; 2:96865922-96865922	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1494C>T; p.A498A; 2:96861844-96861844	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.981G>A; p.S327S; 2:96864364-96864364	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.879C>T; p.Y293Y; 2:96864788-96864788	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1289G>A; p.G430E; 2:96863967-96863967	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.172C>G; p.L58V; 2:96866369-96866369	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2299G>T; p.G767C; 2:96860829-96860829	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1647C>T; p.I549I; 2:96861604-96861604	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1814A>G; p.Y605C; 2:96861314-96861314	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.176C>T; p.T59M; 2:96866365-96866365	pancreas	carcinoma	Substitution - Missense
c.176C>T; p.T59M; 2:96866365-96866365	pancreas	carcinoma	Substitution - Missense
c.176C>T; p.T59M; 2:96866365-96866365	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.468G>T; p.K156N; 2:96865490-96865490	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1631C>T; p.S544L; 2:96861620-96861620	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.206C>T; p.A69V; 2:96866335-96866335	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1016G>A; p.R339Q; 2:96864329-96864329	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1016G>A; p.R339Q; 2:96864329-96864329	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1427T>C; p.V476A; 2:96863698-96863698	large_intestine; colon	adenoma	Substitution - Missense
c.2330A>T; p.H777L; 2:96860798-96860798	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.119C>T; p.T40M; 2:96866422-96866422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2339delG; p.G780fs*15; 2:96860789-96860789	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.12C>T; p.H4H; 2:96867875-96867875	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1575C>T; p.R525R; 2:96861763-96861763	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1903C>T; p.R635W; 2:96861225-96861225	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1760G>A; p.R587H; 2:96861368-96861368	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1275C>T; p.A425A; 2:96863981-96863981	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2162G>A; p.R721Q; 2:96860966-96860966	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.325G>A; p.E109K; 2:96865761-96865761	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1949C>T; p.S650L; 2:96861179-96861179	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1866C>T; p.A622A; 2:96861262-96861262	skin	malignant_melanoma	Substitution - coding silent
c.1804T>A; p.S602T; 2:96861324-96861324	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1179C>T; p.F393F; 2:96864077-96864077	skin	malignant_melanoma	Substitution - coding silent
c.127C>T; p.R43W; 2:96866414-96866414	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1756G>T; p.A586S; 2:96861372-96861372	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1756G>T; p.A586S; 2:96861372-96861372	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1756G>T; p.A586S; 2:96861372-96861372	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.359A>G; p.Y120C; 2:96865727-96865727	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1756G>T; p.A586S; 2:96861372-96861372	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.383G>C; p.C128S; 2:96865703-96865703	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.383G>C; p.C128S; 2:96865703-96865703	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1551C>T; p.C517C; 2:96861787-96861787	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.295T>C; p.C99R; 2:96865893-96865893	breast	carcinoma	Substitution - Missense
c.2331C>T; p.H777H; 2:96860797-96860797	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1314G>T; p.V438V; 2:96863942-96863942	liver	carcinoma	Substitution - coding silent
c.1314G>T; p.V438V; 2:96863942-96863942	liver	carcinoma	Substitution - coding silent
c.1097G>A; p.R366Q; 2:96864248-96864248	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1330G>T; p.G444*; 2:96863926-96863926	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1099C>A; p.P367T; 2:96864246-96864246	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1729T>C; p.C577R; 2:96861399-96861399	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2431G>A; p.D811N; 2:96860697-96860697	skin	malignant_melanoma	Substitution - Missense
c.2060G>A; p.R687H; 2:96861068-96861068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2431G>A; p.D811N; 2:96860697-96860697	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1542C>T; p.D514D; 2:96861796-96861796	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.651C>A; p.G217G; 2:96865099-96865099	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.403C>G; p.P135A; 2:96865683-96865683	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2351C>G; p.S784*; 2:96860777-96860777	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1964C>A; p.A655D; 2:96861164-96861164	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1654C>T; p.L552F; 2:96861597-96861597	skin	malignant_melanoma	Substitution - Missense
c.828C>T; p.T276T; 2:96864839-96864839	skin	malignant_melanoma	Substitution - coding silent
c.511C>T; p.L171F; 2:96865447-96865447	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1629C>T; p.T543T; 2:96861622-96861622	skin	malignant_melanoma	Substitution - coding silent
c.1156C>T; p.L386L; 2:96864100-96864100	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1665T>G; p.S555R; 2:96861586-96861586	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1858C>T; p.R620C; 2:96861270-96861270	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2082G>A; p.L694L; 2:96861046-96861046	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1871C>T; p.A624V; 2:96861257-96861257	skin	malignant_melanoma	Substitution - Missense
c.231C>T; p.S77S; 2:96866310-96866310	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1069C>T; p.R357C; 2:96864276-96864276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2271delG; p.P759fs*36; 2:96860857-96860857	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1573C>T; p.R525C; 2:96861765-96861765	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2095A>G; p.K699E; 2:96861033-96861033	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1503G>A; p.M501I; 2:96861835-96861835	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.789C>T; p.G263G; 2:96864878-96864878	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1987_1988GG>TT; p.G663L; 2:96861140-96861141	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1668G>A; p.K556K; 2:96861583-96861583	skin	malignant_melanoma	Substitution - coding silent
c.555G>T; p.L185L; 2:96865283-96865283	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.374T>C; p.L125P; 2:96865712-96865712	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.374T>C; p.L125P; 2:96865712-96865712	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2170C>A; p.P724T; 2:96860958-96860958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2371C>T; p.R791C; 2:96860757-96860757	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1733A>C; p.H578P; 2:96861395-96861395	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2339_2340insG; p.G781fs*28; 2:96860788-96860789	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2372G>A; p.R791H; 2:96860756-96860756	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1364G>T; p.G455V; 2:96863761-96863761	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2372G>A; p.R791H; 2:96860756-96860756	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1228C>T; p.R410C; 2:96864028-96864028	prostate	carcinoma	Substitution - Missense
c.85C>T; p.P29S; 2:96867802-96867802	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604C>G; p.S535C; 2:96861647-96861647	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2338G>A; p.G780S; 2:96860790-96860790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1697C>T; p.T566M; 2:96861431-96861431	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1219C>T; p.R407W; 2:96864037-96864037	skin	malignant_melanoma	Substitution - Missense
c.629T>C; p.L210P; 2:96865209-96865209	skin	malignant_melanoma	Substitution - Missense
c.1367C>T; p.P456L; 2:96863758-96863758	skin	malignant_melanoma	Substitution - Missense
c.1347C>G; p.L449L; 2:96863778-96863778	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1648T>C; p.C550R; 2:96861603-96861603	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1045C>T; p.H349Y; 2:96864300-96864300	skin	malignant_melanoma	Substitution - Missense
c.2059delC; p.R687fs*59; 2:96861069-96861069	skin; neck	malignant_melanoma	Deletion - Frameshift
c.1104C>T; p.G368G; 2:96864241-96864241	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.124G>A; p.V42I; 2:96866417-96866417	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.209G>A; p.R70Q; 2:96866332-96866332	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1234delC; p.L412fs*3; 2:96864022-96864022	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.799G>C; p.G267R; 2:96864868-96864868	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.2116G>T; p.V706L; 2:96861012-96861012	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2032G>C; p.V678L; 2:96861096-96861096	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.355C>T; p.P119S; 2:96865731-96865731	skin	malignant_melanoma	Substitution - Missense
c.1604C>T; p.S535F; 2:96861647-96861647	NS	NS	Substitution - Missense
c.1553C>T; p.A518V; 2:96861785-96861785	skin	malignant_melanoma	Substitution - Missense
c.2149A>G; p.S717G; 2:96860979-96860979	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.853T>C; p.C285R; 2:96864814-96864814	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.290C>A; p.T97N; 2:96865898-96865898	stomach	adenocarcinoma	Substitution - Missense
c.1923C>G; p.Y641*; 2:96861205-96861205	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.320A>T; p.Q107L; 2:96865868-96865868	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.574C>T; p.L192L; 2:96865264-96865264	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.705C>A; p.V235V; 2:96865045-96865045	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1058A>C; p.Q353P; 2:96864287-96864287	central_nervous_system; thalamus	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.250C>T; p.Q84*; 2:96866291-96866291	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.8C>A; p.P3Q; 2:96867879-96867879	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.199G>A; p.V67M; 2:96866342-96866342	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.864G>A; p.P288P; 2:96864803-96864803	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1558A>G; p.S520G; 2:96861780-96861780	skin; abdomen	malignant_melanoma	Substitution - Missense
c.2085G>T; p.E695D; 2:96861043-96861043	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1530C>T; p.V510V; 2:96861808-96861808	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1214G>T; p.G405V; 2:96864042-96864042	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1707G>T; p.A569A; 2:96861421-96861421	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1213G>T; p.G405W; 2:96864043-96864043	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2225C>T; p.S742F; 2:96860903-96860903	skin	malignant_melanoma	Substitution - Missense
c.2386G>T; p.G796W; 2:96860742-96860742	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.605A>C; p.K202T; 2:96865233-96865233	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2443C>T; p.R815C; 2:96860685-96860685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.350T>C; p.L117P; 2:96865736-96865736	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1898G>A; p.G633E; 2:96861230-96861230	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1274C>T; p.A425V; 2:96863982-96863982	skin	malignant_melanoma	Substitution - Missense
c.1898G>A; p.G633E; 2:96861230-96861230	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.614A>G; p.Y205C; 2:96865224-96865224	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database