Entrez Gene

Basic Information
Gene ID	5358
Name	PLS3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.412G>T; p.E138*; 23:115629879-115629879	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1721_1722GT>AC; p.S574>?; 23:115647978-115647979	lung	carcinoma; adenocarcinoma	Complex
c.1115A>G; p.N372S; 23:115643440-115643440	large_intestine; colon	carcinoma	Substitution - Missense
c.127G>C; p.E43Q; 23:115622299-115622299	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1115A>G; p.N372S; 23:115643440-115643440	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.649G>A; p.E217K; 23:115634947-115634947	breast	carcinoma	Substitution - Missense
c.1132C>G; p.P378A; 23:115643457-115643457	NS	NS	Substitution - Missense
c.276C>T; p.T92T; 23:115629236-115629236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.293A>C; p.N98T; 23:115629253-115629253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.711C>T; p.I237I; 23:115635009-115635009	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.418G>T; p.D140Y; 23:115629885-115629885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.46G>A; p.E16K; 23:115610296-115610296	breast	carcinoma	Substitution - Missense
c.1254T>A; p.H418Q; 23:115645091-115645091	skin	malignant_melanoma	Substitution - Missense
c.1107C>T; p.F369F; 23:115643432-115643432	skin	malignant_melanoma	Substitution - coding silent
c.368-1G>A; p.?; 23:115629834-115629834	ovary	carcinoma; serous_carcinoma	Unknown
c.838C>G; p.H280D; 23:115636925-115636925	urinary_tract; bladder	carcinoma	Substitution - Missense
c.949G>A; p.G317S; 23:115640465-115640465	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.22C>T; p.Q8*; 23:115610272-115610272	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.676C>T; p.L226L; 23:115634974-115634974	skin	malignant_melanoma	Substitution - coding silent
c.340A>T; p.S114C; 23:115629300-115629300	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1367A>G; p.N456S; 23:115646176-115646176	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1353G>A; p.P451P; 23:115646162-115646162	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.319G>T; p.G107C; 23:115629279-115629279	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.255A>C; p.K85N; 23:115629215-115629215	skin	malignant_melanoma	Substitution - Missense
c.1262C>T; p.A421V; 23:115645099-115645099	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1262C>T; p.A421V; 23:115645099-115645099	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.337T>C; p.S113P; 23:115629297-115629297	NS	NS	Substitution - Missense
c.952G>A; p.E318K; 23:115640468-115640468	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.226G>A; p.E76K; 23:115622398-115622398	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.768A>G; p.R256R; 23:115636855-115636855	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.524C>T; p.P175L; 23:115634023-115634023	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.754G>T; p.A252S; 23:115636841-115636841	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1869G>A; p.M623I; 23:115649537-115649537	breast	carcinoma	Substitution - Missense
c.858G>A; p.W286*; 23:115636945-115636945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.501-3delC; p.?; 23:115633997-115633997	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.784G>C; p.E262Q; 23:115636871-115636871	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.261T>C; p.S87S; 23:115629221-115629221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1673T>G; p.L558*; 23:115647930-115647930	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1479G>C; p.L493L; 23:115646503-115646503	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.896C>T; p.S299F; 23:115640412-115640412	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1009G>T; p.A337S; 23:115643334-115643334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.444A>G; p.P148P; 23:115629911-115629911	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.919A>G; p.N307D; 23:115640435-115640435	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1742A>G; p.D581G; 23:115647999-115647999	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1775T>C; p.M592T; 23:115649443-115649443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.238-2A>T; p.?; 23:115629196-115629196	lung	carcinoma; adenocarcinoma	Unknown
c.892-2A>T; p.?; 23:115640406-115640406	liver	carcinoma	Unknown
c.1466G>A; p.G489E; 23:115646490-115646490	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1745A>G; p.K582R; 23:115648002-115648002	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1345C>A; p.P449T; 23:115646154-115646154	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.868A>T; p.N290Y; 23:115636955-115636955	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1359G>A; p.L453L; 23:115646168-115646168	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.762A>T; p.L254F; 23:115636849-115636849	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1047_1050delCAGA; p.R350fs*17; 23:115643372-115643375	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1847T>C; p.M616T; 23:115649515-115649515	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1422T>A; p.A474A; 23:115646446-115646446	liver	carcinoma	Substitution - coding silent
c.1506G>T; p.M502I; 23:115646530-115646530	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1010C>T; p.A337V; 23:115643335-115643335	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.869A>G; p.N290S; 23:115636956-115636956	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.869A>G; p.N290S; 23:115636956-115636956	breast	carcinoma	Substitution - Missense
c.869A>G; p.N290S; 23:115636956-115636956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.775G>C; p.E259Q; 23:115636862-115636862	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1089C>G; p.P363P; 23:115643414-115643414	oesophagus	carcinoma	Substitution - coding silent
c.163G>T; p.E55*; 23:115622335-115622335	skin	malignant_melanoma	Substitution - Nonsense
c.163G>T; p.E55*; 23:115622335-115622335	skin	malignant_melanoma	Substitution - Nonsense
c.1796G>C; p.R599T; 23:115649464-115649464	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1016G>T; p.S339I; 23:115643341-115643341	liver	carcinoma	Substitution - Missense
c.721G>A; p.A241T; 23:115635019-115635019	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.927C>T; p.I309I; 23:115640443-115640443	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.385T>A; p.F129I; 23:115629852-115629852	skin	malignant_melanoma	Substitution - Missense
c.1186G>A; p.E396K; 23:115645023-115645023	breast	carcinoma	Substitution - Missense
c.110T>C; p.L37P; 23:115622282-115622282	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.37G>A; p.E13K; 23:115610287-115610287	liver	carcinoma	Substitution - Missense
c.37G>A; p.E13K; 23:115610287-115610287	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.555G>C; p.K185N; 23:115634054-115634054	breast	carcinoma	Substitution - Missense
c.573C>T; p.F191F; 23:115634072-115634072	breast	carcinoma	Substitution - coding silent
c.915T>A; p.L305L; 23:115640431-115640431	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.69A>C; p.K23N; 23:115610319-115610319	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.805C>T; p.P269S; 23:115636892-115636892	skin	malignant_melanoma	Substitution - Missense
c.762A>G; p.L254L; 23:115636849-115636849	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.317T>A; p.L106Q; 23:115629277-115629277	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1149A>G; p.P383P; 23:115643474-115643474	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.294C>T; p.N98N; 23:115629254-115629254	breast	carcinoma	Substitution - coding silent
c.745G>A; p.E249K; 23:115635043-115635043	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.745G>A; p.E249K; 23:115635043-115635043	urinary_tract; bladder	carcinoma	Substitution - Missense
c.932C>G; p.P311R; 23:115640448-115640448	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.299A>C; p.K100T; 23:115629259-115629259	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1676T>G; p.I559S; 23:115647933-115647933	central_nervous_system; brain	glioma	Substitution - Missense
c.1653C>T; p.S551S; 23:115647910-115647910	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.301G>T; p.E101*; 23:115629261-115629261	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1798G>C; p.V600L; 23:115649466-115649466	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1078A>G; p.S360G; 23:115643403-115643403	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.795G>A; p.M265I; 23:115636882-115636882	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1454A>G; p.D485G; 23:115646478-115646478	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1307T>A; p.I436N; 23:115646116-115646116	skin	malignant_melanoma	Substitution - Missense
c.1467G>A; p.G489G; 23:115646491-115646491	skin	malignant_melanoma	Substitution - coding silent
c.1776G>T; p.M592I; 23:115649444-115649444	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.745G>C; p.E249Q; 23:115635043-115635043	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1454A>C; p.D485A; 23:115646478-115646478	breast	carcinoma; ductal_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database