Entrez Gene

Basic Information
Gene ID	51474
Name	LIMA1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.171C>T; p.T57T; 12:50222480-50222480	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.73C>G; p.L25V; 12:50248679-50248679	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2248C>T; p.R750W; 12:50177096-50177096	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2248C>T; p.R750W; 12:50177096-50177096	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1170C>T; p.C390C; 12:50182008-50182008	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.570T>A; p.Y190*; 12:50222081-50222081	prostate	carcinoma	Substitution - Nonsense
c.286G>T; p.E96*; 12:50222365-50222365	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2035C>G; p.L679V; 12:50177309-50177309	breast	carcinoma	Substitution - Missense
c.2201G>T; p.G734V; 12:50177143-50177143	thyroid	other; neoplasm	Substitution - Missense
c.1018G>A; p.E340K; 12:50195842-50195842	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1018G>A; p.E340K; 12:50195842-50195842	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.920A>T; p.E307V; 12:50200829-50200829	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1509C>A; p.V503V; 12:50177835-50177835	breast	carcinoma	Substitution - coding silent
c.930C>T; p.P310P; 12:50200819-50200819	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.503C>T; p.S168F; 12:50222148-50222148	skin	malignant_melanoma	Substitution - Missense
c.508C>T; p.H170Y; 12:50222143-50222143	thyroid	other; neoplasm	Substitution - Missense
c.2220C>G; p.L740L; 12:50177124-50177124	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1819delA; p.T607fs*74; 12:50177525-50177525	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.2220C>G; p.L740L; 12:50177124-50177124	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1916C>T; p.A639V; 12:50177428-50177428	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.574G>A; p.V192I; 12:50222077-50222077	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.358C>A; p.Q120K; 12:50222293-50222293	breast	carcinoma	Substitution - Missense
c.419G>A; p.G140D; 12:50222232-50222232	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.788C>A; p.S263*; 12:50204628-50204628	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.26G>A; p.R9Q; 12:50248726-50248726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.256C>T; p.H86Y; 12:50222395-50222395	urinary_tract; bladder	carcinoma	Substitution - Missense
c.26G>A; p.R9Q; 12:50248726-50248726	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.256C>T; p.H86Y; 12:50222395-50222395	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.26G>A; p.R9Q; 12:50248726-50248726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1208T>C; p.L403P; 12:50181970-50181970	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1509C>T; p.V503V; 12:50177835-50177835	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1406delA; p.N469fs*25; 12:50177938-50177938	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1030+1G>A; p.?; 12:50195829-50195829	lung	carcinoma; adenocarcinoma	Unknown
c.1713C>G; p.V571V; 12:50177631-50177631	prostate	carcinoma	Substitution - coding silent
c.996G>A; p.L332L; 12:50195864-50195864	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1489C>T; p.P497S; 12:50177855-50177855	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2050G>A; p.A684T; 12:50177294-50177294	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.254C>T; p.S85F; 12:50222397-50222397	NS	NS	Substitution - Missense
c.1274+1G>T; p.?; 12:50181903-50181903	lung	carcinoma; adenocarcinoma	Unknown
c.733A>G; p.T245A; 12:50204683-50204683	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2152G>T; p.E718*; 12:50177192-50177192	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1371G>A; p.G457G; 12:50177973-50177973	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.64G>T; p.E22*; 12:50248688-50248688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.64G>T; p.E22*; 12:50248688-50248688	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1770A>G; p.P590P; 12:50177574-50177574	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2243G>T; p.R748I; 12:50177101-50177101	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.609A>C; p.K203N; 12:50222042-50222042	thyroid	other; neoplasm	Substitution - Missense
c.1969G>T; p.E657*; 12:50177375-50177375	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.83A>G; p.K28R; 12:50248669-50248669	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1094C>T; p.S365F; 12:50192498-50192498	central_nervous_system; brain	glioma	Substitution - Missense
c.1395G>A; p.W465*; 12:50177949-50177949	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1940A>G; p.N647S; 12:50177404-50177404	breast	carcinoma	Substitution - Missense
c.481_482insA; p.M161fs*11; 12:50222169-50222170	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Insertion - Frameshift
c.481_482insA; p.M161fs*11; 12:50222169-50222170	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Insertion - Frameshift
c.763C>T; p.R255*; 12:50204653-50204653	central_nervous_system; brain	glioma	Substitution - Nonsense
c.481_482insA; p.M161fs*11; 12:50222169-50222170	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1905A>G; p.Q635Q; 12:50177439-50177439	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.506G>T; p.R169M; 12:50222145-50222145	thyroid	other; neoplasm	Substitution - Missense
c.2272G>A; p.E758K; 12:50177072-50177072	breast	carcinoma	Substitution - Missense
c.622C>T; p.Q208*; 12:50222029-50222029	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.507G>C; p.R169S; 12:50222144-50222144	thyroid	other; neoplasm	Substitution - Missense
c.334G>A; p.A112T; 12:50222317-50222317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.797C>T; p.S266F; 12:50204619-50204619	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1047G>C; p.K349N; 12:50192545-50192545	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1947A>G; p.G649G; 12:50177397-50177397	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.796T>C; p.S266P; 12:50204620-50204620	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2196G>A; p.W732*; 12:50177148-50177148	liver	carcinoma	Substitution - Nonsense
c.178C>G; p.L60V; 12:50222473-50222473	breast	carcinoma	Substitution - Missense
c.1126_1127CC>AT; p.P376I; 12:50192465-50192466	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.888C>T; p.G296G; 12:50200861-50200861	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.888C>T; p.G296G; 12:50200861-50200861	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.888C>T; p.G296G; 12:50200861-50200861	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1003C>A; p.R335S; 12:50195857-50195857	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1766G>A; p.R589H; 12:50177578-50177578	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1605delC; p.T536fs*38; 12:50177739-50177739	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1140+1G>A; p.?; 12:50192451-50192451	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.219G>A; p.K73K; 12:50222432-50222432	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.889G>A; p.E297K; 12:50200860-50200860	breast	carcinoma	Substitution - Missense
c.306C>A; p.D102E; 12:50222345-50222345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.579G>A; p.P193P; 12:50222072-50222072	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1607C>T; p.T536I; 12:50177737-50177737	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.442G>A; p.G148S; 12:50222209-50222209	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.25C>T; p.R9W; 12:50248727-50248727	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.25C>T; p.R9W; 12:50248727-50248727	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.95C>T; p.S32L; 12:50248657-50248657	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2132T>C; p.V711A; 12:50177212-50177212	liver	carcinoma	Substitution - Missense
c.1486G>A; p.A496T; 12:50177858-50177858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.84G>T; p.K28N; 12:50248668-50248668	urinary_tract; bladder	carcinoma	Substitution - Missense
c.539A>G; p.N180S; 12:50222112-50222112	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1417G>C; p.E473Q; 12:50177927-50177927	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.307C>A; p.H103N; 12:50222344-50222344	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.778C>T; p.P260S; 12:50204638-50204638	skin	malignant_melanoma	Substitution - Missense
c.938C>A; p.P313H; 12:50200811-50200811	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.938C>A; p.P313H; 12:50200811-50200811	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.938C>A; p.P313H; 12:50200811-50200811	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1205G>A; p.R402H; 12:50181973-50181973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.973-4G>T; p.?; 12:50195891-50195891	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1304G>T; p.R435I; 12:50178040-50178040	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1304G>T; p.R435I; 12:50178040-50178040	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1584G>T; p.L528L; 12:50177760-50177760	breast	carcinoma	Substitution - coding silent
c.305A>T; p.D102V; 12:50222346-50222346	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1655C>G; p.S552*; 12:50177689-50177689	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.504C>G; p.S168S; 12:50222147-50222147	thyroid	other; neoplasm	Substitution - coding silent
c.1678G>A; p.D560N; 12:50177666-50177666	skin	malignant_melanoma	Substitution - Missense
c.2031G>A; p.E677E; 12:50177313-50177313	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1413C>T; p.N471N; 12:50177931-50177931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1822G>A; p.V608M; 12:50177522-50177522	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.784C>G; p.L262V; 12:50204632-50204632	urinary_tract; bladder	carcinoma	Substitution - Missense
c.747G>T; p.E249D; 12:50204669-50204669	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.772G>C; p.E258Q; 12:50204644-50204644	breast	carcinoma	Substitution - Missense
c.1668G>A; p.W556*; 12:50177676-50177676	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1668G>A; p.W556*; 12:50177676-50177676	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.697G>A; p.D233N; 12:50206002-50206002	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.575T>C; p.V192A; 12:50222076-50222076	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.92C>T; p.S31L; 12:50248660-50248660	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1792C>G; p.Q598E; 12:50177552-50177552	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1012C>T; p.P338S; 12:50195848-50195848	skin	malignant_melanoma	Substitution - Missense
c.231G>T; p.E77D; 12:50222420-50222420	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1105A>G; p.S369G; 12:50192487-50192487	ovary	other; neoplasm	Substitution - Missense
c.1616G>C; p.G539A; 12:50177728-50177728	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1473A>T; p.P491P; 12:50177871-50177871	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1932G>C; p.K644N; 12:50177412-50177412	breast	carcinoma	Substitution - Missense
c.1543C>G; p.Q515E; 12:50177801-50177801	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>T; p.S326F; 12:50195883-50195883	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.711_712CC>TT; p.P238S; 12:50205987-50205988	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.541A>G; p.T181A; 12:50222110-50222110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.172delG; p.E58fs*12; 12:50222479-50222479	liver	carcinoma	Deletion - Frameshift
c.1739G>C; p.R580P; 12:50177605-50177605	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.493C>T; p.L165L; 12:50222158-50222158	skin	malignant_melanoma	Substitution - coding silent
c.1879G>C; p.G627R; 12:50177465-50177465	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.435C>G; p.I145M; 12:50222216-50222216	urinary_tract; bladder	carcinoma	Substitution - Missense
c.72T>G; p.S24S; 12:50248680-50248680	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.608A>T; p.K203I; 12:50222043-50222043	thyroid	other; neoplasm	Substitution - Missense
c.77T>G; p.V26G; 12:50248675-50248675	liver	carcinoma	Substitution - Missense
c.1078C>T; p.P360S; 12:50192514-50192514	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.651A>G; p.R217R; 12:50206048-50206048	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.651A>G; p.R217R; 12:50206048-50206048	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent

The somatic mutations from COSMIC database