Entrez Gene

Basic Information
Gene ID	5054
Name	SERPINE1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.625C>T; p.R209C; 7:101131994-101131994	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432C>A; p.V144V; 7:101130581-101130581	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.114C>T; p.F38F; 7:101128507-101128507	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.442G>A; p.D148N; 7:101130591-101130591	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.49G>A; p.V17I; 7:101128442-101128442	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.152A>G; p.K51R; 7:101128545-101128545	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>A; p.A95T; 7:101130432-101130432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.256G>A; p.G86R; 7:101128649-101128649	skin	malignant_melanoma	Substitution - Missense
c.742G>T; p.E248*; 7:101133736-101133736	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.520T>C; p.L174L; 7:101131889-101131889	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.186G>T; p.V62V; 7:101128579-101128579	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.839A>G; p.Q280R; 7:101133833-101133833	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1018G>A; p.V340I; 7:101135732-101135732	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1018G>A; p.V340I; 7:101135732-101135732	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1018G>A; p.V340I; 7:101135732-101135732	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.879C>A; p.P293P; 7:101133873-101133873	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.43G>A; p.A15T; 7:101128436-101128436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1023G>A; p.A341A; 7:101135737-101135737	central_nervous_system; brain	glioma	Substitution - coding silent
c.439G>T; p.V147L; 7:101130588-101130588	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.272-1G>C; p.?; 7:101130420-101130420	breast	carcinoma	Unknown
c.602C>T; p.P201L; 7:101131971-101131971	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.72G>T; p.V24V; 7:101128465-101128465	breast	carcinoma	Substitution - coding silent
c.244C>T; p.Q82*; 7:101128637-101128637	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.695A>G; p.N232S; 7:101132064-101132064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.25T>G; p.C9G; 7:101128418-101128418	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.356C>T; p.A119V; 7:101130505-101130505	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.356C>T; p.A119V; 7:101130505-101130505	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.340A>G; p.I114V; 7:101130489-101130489	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.899+2T>C; p.?; 7:101133895-101133895	breast	carcinoma	Unknown
c.1040T>G; p.V347G; 7:101135754-101135754	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.574C>A; p.L192I; 7:101131943-101131943	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.223G>A; p.G75R; 7:101128616-101128616	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>G; p.P250A; 7:101133742-101133742	breast	carcinoma	Substitution - Missense
c.461G>A; p.R154K; 7:101130610-101130610	urinary_tract; bladder	carcinoma	Substitution - Missense
c.486G>T; p.W162C; 7:101130635-101130635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.880C>T; p.R294C; 7:101133874-101133874	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>C; p.A95P; 7:101130432-101130432	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.77A>G; p.H26R; 7:101128470-101128470	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.144_145GG>AA; p.A49T; 7:101128537-101128538	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.285C>T; p.A95A; 7:101130434-101130434	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.417G>T; p.L139L; 7:101130566-101130566	breast	carcinoma	Substitution - coding silent
c.522G>A; p.L174L; 7:101131891-101131891	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.714G>A; p.T238T; 7:101133708-101133708	breast	carcinoma	Substitution - coding silent
c.714G>A; p.T238T; 7:101133708-101133708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.629G>A; p.R210H; 7:101131998-101131998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.629G>A; p.R210H; 7:101131998-101131998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.407T>C; p.F136S; 7:101130556-101130556	breast	carcinoma	Substitution - Missense
c.629G>A; p.R210H; 7:101131998-101131998	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>T; p.E267*; 7:101133793-101133793	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.226G>T; p.E76*; 7:101128619-101128619	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1047C>G; p.I349M; 7:101135761-101135761	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1120G>A; p.E374K; 7:101137033-101137033	skin	malignant_melanoma	Substitution - Missense
c.742G>A; p.E248K; 7:101133736-101133736	skin	malignant_melanoma	Substitution - Missense
c.100C>A; p.L34M; 7:101128493-101128493	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.191C>T; p.S64L; 7:101128584-101128584	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.294C>T; p.L98L; 7:101130443-101130443	breast	carcinoma	Substitution - coding silent
c.524T>G; p.L175R; 7:101131893-101131893	pancreas	carcinoma	Substitution - Missense
c.1184T>C; p.F395S; 7:101137417-101137417	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.713C>T; p.T238M; 7:101133707-101133707	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.513C>A; p.I171I; 7:101131882-101131882	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1184T>C; p.F395S; 7:101137417-101137417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.713C>T; p.T238M; 7:101133707-101133707	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.632T>A; p.L211H; 7:101132001-101132001	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.632T>A; p.L211H; 7:101132001-101132001	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.257G>T; p.G86V; 7:101128650-101128650	prostate	carcinoma	Substitution - Missense
c.156C>T; p.D52D; 7:101128549-101128549	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1152G>C; p.V384V; 7:101137065-101137065	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.364G>A; p.V122I; 7:101130513-101130513	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.364G>A; p.V122I; 7:101130513-101130513	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.782C>A; p.A261D; 7:101133776-101133776	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.286C>T; p.P96S; 7:101130435-101130435	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.527G>C; p.G176A; 7:101131896-101131896	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.750C>T; p.P250P; 7:101133744-101133744	kidney	other; neoplasm	Substitution - coding silent
c.541G>A; p.D181N; 7:101131910-101131910	skin	malignant_melanoma	Substitution - Missense
c.1105C>T; p.R369C; 7:101137018-101137018	skin	malignant_melanoma	Substitution - Missense
c.1098C>T; p.V366V; 7:101137011-101137011	breast	carcinoma	Substitution - coding silent
c.609C>T; p.P203P; 7:101131978-101131978	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.11C>G; p.S4C; 7:101128404-101128404	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.315C>A; p.L105L; 7:101130464-101130464	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.11C>G; p.S4C; 7:101128404-101128404	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.11C>G; p.S4C; 7:101128404-101128404	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1152G>T; p.V384V; 7:101137065-101137065	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.355G>T; p.A119S; 7:101130504-101130504	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1158G>A; p.R386R; 7:101137071-101137071	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.100C>G; p.L34V; 7:101128493-101128493	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.843C>T; p.L281L; 7:101133837-101133837	skin	malignant_melanoma	Substitution - coding silent
c.145G>T; p.A49S; 7:101128538-101128538	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.428C>A; p.T143K; 7:101130577-101130577	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.342C>T; p.I114I; 7:101130491-101130491	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.342C>T; p.I114I; 7:101130491-101130491	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.124G>A; p.V42M; 7:101128517-101128517	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.978G>T; p.Q326H; 7:101135572-101135572	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.948G>A; p.L316L; 7:101135542-101135542	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.854G>A; p.W285*; 7:101133848-101133848	skin	malignant_melanoma	Substitution - Nonsense
c.461G>T; p.R154I; 7:101130610-101130610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>T; p.P59P; 7:101128570-101128570	skin	malignant_melanoma	Substitution - coding silent
c.312G>A; p.E104E; 7:101130461-101130461	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.815C>T; p.A272V; 7:101133809-101133809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.826A>T; p.I276F; 7:101133820-101133820	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.225A>C; p.G75G; 7:101128618-101128618	skin	malignant_melanoma	Substitution - coding silent
c.689A>C; p.K230T; 7:101132058-101132058	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.867G>A; p.M289I; 7:101133861-101133861	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database