Entrez Gene

Basic Information
Gene ID	4988
Name	OPRM1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1133C>T; p.T378M; 6:154091441-154091441	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.844A>G; p.R282G; 6:154091152-154091152	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.829C>T; p.L277F; 6:154091137-154091137	skin	malignant_melanoma	Substitution - Missense
c.1105C>T; p.R369C; 6:154091413-154091413	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1105C>T; p.R369C; 6:154091413-154091413	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1105C>T; p.R369C; 6:154091413-154091413	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1240G>C; p.G414R; 6:154093345-154093345	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1105C>T; p.R369C; 6:154091413-154091413	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1105C>T; p.R369C; 6:154091413-154091413	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1105C>T; p.R369C; 6:154091413-154091413	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1105C>T; p.R369C; 6:154091413-154091413	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.876C>T; p.I292I; 6:154091184-154091184	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1015G>A; p.A339T; 6:154091323-154091323	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1031A>G; p.N344S; 6:154091339-154091339	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>A; p.A104T; 6:154089845-154089845	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.267C>T; p.F89F; 6:154039811-154039811	skin	malignant_melanoma	Substitution - coding silent
c.371C>T; p.P124L; 6:154089906-154089906	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.190A>G; p.S64G; 6:154039734-154039734	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.813A>C; p.K271N; 6:154091121-154091121	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.7A>C; p.S3R; 6:154039551-154039551	thyroid	other; neoplasm	Substitution - Missense
c.1022T>A; p.L341Q; 6:154091330-154091330	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.723C>T; p.F241F; 6:154091031-154091031	breast	carcinoma	Substitution - coding silent
c.833G>A; p.R278Q; 6:154091141-154091141	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1040G>C; p.R347P; 6:154091348-154091348	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.833G>A; p.R278Q; 6:154091141-154091141	skin	malignant_melanoma	Substitution - Missense
c.1171C>T; p.P391S; 6:154093276-154093276	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.171C>G; p.S57R; 6:154039715-154039715	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.468C>T; p.S156S; 6:154090003-154090003	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.779G>A; p.R260H; 6:154091087-154091087	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.779G>A; p.R260H; 6:154091087-154091087	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.779G>A; p.R260H; 6:154091087-154091087	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.779G>A; p.R260H; 6:154091087-154091087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1291C>T; p.R431C; 6:154093396-154093396	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1242A>T; p.G414G; 6:154093347-154093347	breast	carcinoma	Substitution - coding silent
c.793C>T; p.R265C; 6:154091101-154091101	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.464C>T; p.T155I; 6:154089999-154089999	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.136G>A; p.G46S; 6:154039680-154039680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.832C>T; p.R278*; 6:154091140-154091140	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.931C>T; p.P311S; 6:154091239-154091239	skin	malignant_melanoma	Substitution - Missense
c.349G>T; p.A117S; 6:154089884-154089884	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.547C>A; p.P183T; 6:154090082-154090082	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1027G>A; p.E343K; 6:154091335-154091335	skin	malignant_melanoma	Substitution - Missense
c.106C>T; p.H36Y; 6:154039650-154039650	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1256A>G; p.Y419C; 6:154093361-154093361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1323A>G; p.G441G; 6:154093428-154093428	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1323A>G; p.G441G; 6:154093428-154093428	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1079T>C; p.I360T; 6:154091387-154091387	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1311C>A; p.S437R; 6:154093416-154093416	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.588C>T; p.L196L; 6:154090123-154090123	skin	malignant_melanoma	Substitution - coding silent
c.1011T>C; p.L337L; 6:154091319-154091319	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.873C>T; p.F291F; 6:154091181-154091181	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.775T>C; p.L259L; 6:154091083-154091083	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.12C>T; p.S4S; 6:154039556-154039556	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.237C>T; p.I79I; 6:154039781-154039781	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.237C>T; p.I79I; 6:154039781-154039781	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.160G>A; p.G54R; 6:154039704-154039704	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.85G>T; p.G29C; 6:154039629-154039629	liver	carcinoma	Substitution - Missense
c.85G>T; p.G29C; 6:154039629-154039629	liver	carcinoma	Substitution - Missense
c.582G>A; p.W194*; 6:154090117-154090117	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.85G>T; p.G29C; 6:154039629-154039629	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.752C>A; p.T251N; 6:154091060-154091060	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.369G>A; p.L123L; 6:154089904-154089904	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.717C>A; p.F239L; 6:154091025-154091025	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.947A>T; p.Q316L; 6:154091255-154091255	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.215C>T; p.T72M; 6:154039759-154039759	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.215C>T; p.T72M; 6:154039759-154039759	urinary_tract; bladder	carcinoma	Substitution - Missense
c.215C>T; p.T72M; 6:154039759-154039759	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.689G>T; p.W230L; 6:154090997-154090997	breast	carcinoma	Substitution - Missense
c.1234C>T; p.L412L; 6:154093339-154093339	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.243C>T; p.C81C; 6:154039787-154039787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.135C>T; p.C45C; 6:154039679-154039679	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1292G>A; p.R431H; 6:154093397-154093397	breast	carcinoma	Substitution - Missense
c.785A>G; p.K262R; 6:154091093-154091093	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.186C>A; p.T62T; 6:154039730-154039730	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1083G>A; p.E361E; 6:154091391-154091391	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.146G>T; p.R49L; 6:154039690-154039690	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.346G>T; p.D116Y; 6:154089881-154089881	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.146G>T; p.R49L; 6:154039690-154039690	liver	carcinoma	Substitution - Missense
c.941C>T; p.T314M; 6:154091249-154091249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.435G>A; p.V145V; 6:154089970-154089970	skin	malignant_melanoma	Substitution - coding silent
c.1006G>T; p.V336F; 6:154091314-154091314	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.597C>A; p.A199A; 6:154090132-154090132	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1066A>G; p.T356A; 6:154091374-154091374	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1106G>A; p.R369H; 6:154091414-154091414	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1106G>A; p.R369H; 6:154091414-154091414	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.794G>A; p.R265H; 6:154091102-154091102	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1111A>C; p.N371H; 6:154091419-154091419	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.462C>A; p.F154L; 6:154089997-154089997	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.974C>T; p.A325V; 6:154091282-154091282	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1035C>A; p.F345L; 6:154091343-154091343	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.314C>A; p.T105N; 6:154089849-154089849	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.904G>C; p.V302L; 6:154091212-154091212	breast	carcinoma	Substitution - Missense
c.979G>C; p.G327R; 6:154091287-154091287	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.966C>A; p.F322L; 6:154091274-154091274	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1209C>T; p.G403G; 6:154093314-154093314	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.93G>A; p.W31*; 6:154039637-154039637	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1024G>A; p.D342N; 6:154091332-154091332	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.466A>G; p.S156G; 6:154090001-154090001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.864G>A; p.V288V; 6:154091172-154091172	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1164+4C>T; p.?; 6:154091476-154091476	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.1014T>C; p.Y338Y; 6:154091322-154091322	breast	carcinoma	Substitution - coding silent
c.753C>T; p.T251T; 6:154091061-154091061	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.551G>A; p.R184Q; 6:154090086-154090086	pancreas	carcinoma	Substitution - Missense
c.753C>T; p.T251T; 6:154091061-154091061	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - coding silent
c.551G>A; p.R184Q; 6:154090086-154090086	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.903C>T; p.Y301Y; 6:154091211-154091211	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.903C>T; p.Y301Y; 6:154091211-154091211	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.187G>A; p.G63S; 6:154039731-154039731	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.594A>G; p.S198S; 6:154090129-154090129	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1035C>T; p.F345F; 6:154091343-154091343	skin	malignant_melanoma	Substitution - coding silent
c.870G>T; p.V290V; 6:154091178-154091178	breast	carcinoma	Substitution - coding silent
c.136G>T; p.G46C; 6:154039680-154039680	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.118A>G; p.N40D; 6:154039662-154039662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.186C>T; p.T62T; 6:154039730-154039730	pancreas	carcinoma	Substitution - coding silent
c.1002C>A; p.N334K; 6:154091310-154091310	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.261A>C; p.G87G; 6:154039805-154039805	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1040G>A; p.R347Q; 6:154091348-154091348	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.942G>A; p.T314T; 6:154091250-154091250	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1040G>A; p.R347Q; 6:154091348-154091348	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.870G>A; p.V290V; 6:154091178-154091178	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.82C>T; p.P28S; 6:154039626-154039626	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1099C>T; p.R367*; 6:154091407-154091407	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.24G>A; p.T8T; 6:154039568-154039568	oesophagus	carcinoma	Substitution - coding silent
c.904G>A; p.V302I; 6:154091212-154091212	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1073C>T; p.S358F; 6:154091381-154091381	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1073C>T; p.S358F; 6:154091381-154091381	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.904G>A; p.V302I; 6:154091212-154091212	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1333C>T; p.L445L; 6:154093438-154093438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.239T>C; p.V80A; 6:154039783-154039783	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.146G>A; p.R49H; 6:154039690-154039690	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1100G>A; p.R367Q; 6:154091408-154091408	skin	malignant_melanoma	Substitution - Missense
c.809C>T; p.S270F; 6:154091117-154091117	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1206A>T; p.Q402H; 6:154093311-154093311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1206A>T; p.Q402H; 6:154093311-154093311	thyroid	other; neoplasm	Substitution - Missense
c.1272C>T; p.I424I; 6:154093377-154093377	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1100G>T; p.R367L; 6:154091408-154091408	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.607C>A; p.P203T; 6:154090142-154090142	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1164+5G>A; p.?; 6:154091477-154091477	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1116T>G; p.T372T; 6:154091424-154091424	skin	malignant_melanoma	Substitution - coding silent
c.918C>A; p.A306A; 6:154091226-154091226	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.794G>T; p.R265L; 6:154091102-154091102	meninges	meningioma; haemangiopericytic	Substitution - Missense
c.605T>G; p.L202R; 6:154090140-154090140	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.993C>G; p.S331R; 6:154091301-154091301	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.365delC; p.L123fs*6; 6:154089900-154089900	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Deletion - Frameshift
c.678A>C; p.P226P; 6:154090986-154090986	skin	malignant_melanoma	Substitution - coding silent
c.370C>T; p.P124S; 6:154089905-154089905	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.547C>T; p.P183S; 6:154090082-154090082	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.815A>G; p.E272G; 6:154091123-154091123	breast	carcinoma	Substitution - Missense
c.877G>A; p.V293I; 6:154091185-154091185	stomach	carcinoma; adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database