Entrez Gene

Basic Information
Gene ID	4327
Name	MMP19

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.619C>T; p.R207C; 12:55839643-55839643	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1463C>T; p.P488L; 12:55837100-55837100	skin	malignant_melanoma	Substitution - Missense
c.1075C>T; p.R359C; 12:55837668-55837668	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.125T>C; p.L42P; 12:55842401-55842401	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.131G>A; p.G44E; 12:55842395-55842395	skin	malignant_melanoma	Substitution - Missense
c.1424G>A; p.R475Q; 12:55837139-55837139	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1461T>A; p.T487T; 12:55837102-55837102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.736G>C; p.D246H; 12:55839526-55839526	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.520G>T; p.G174W; 12:55840667-55840667	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1016C>T; p.A339V; 12:55837887-55837887	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1016C>T; p.A339V; 12:55837887-55837887	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1002C>T; p.P334P; 12:55837901-55837901	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.376C>T; p.R126W; 12:55840811-55840811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.24G>A; p.L8L; 12:55842807-55842807	skin	malignant_melanoma	Substitution - coding silent
c.40A>G; p.M14V; 12:55842791-55842791	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1053C>T; p.F351F; 12:55837850-55837850	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1195G>A; p.G399R; 12:55837368-55837368	pancreas	carcinoma	Substitution - Missense
c.579C>T; p.D193D; 12:55839683-55839683	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.733C>T; p.P245S; 12:55839529-55839529	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.728T>C; p.L243P; 12:55839534-55839534	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.879G>A; p.L293L; 12:55838622-55838622	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1326C>A; p.F442L; 12:55837237-55837237	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1326C>A; p.F442L; 12:55837237-55837237	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.378G>T; p.R126R; 12:55840809-55840809	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.776G>A; p.S259N; 12:55838725-55838725	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.282G>A; p.K94K; 12:55841128-55841128	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1287C>A; p.P429P; 12:55837276-55837276	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1472C>T; p.T491M; 12:55837091-55837091	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1289C>A; p.S430*; 12:55837274-55837274	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.65G>T; p.G22V; 12:55842766-55842766	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.122C>T; p.P41L; 12:55842404-55842404	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.S157S; 12:55840716-55840716	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1364T>G; p.L455R; 12:55837199-55837199	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1001C>T; p.P334L; 12:55837902-55837902	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.377G>A; p.R126Q; 12:55840810-55840810	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>A; p.A56T; 12:55842360-55842360	meninges	meningioma	Substitution - Missense
c.499T>A; p.S167T; 12:55840688-55840688	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.807G>T; p.E269D; 12:55838694-55838694	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.577G>A; p.D193N; 12:55839685-55839685	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.268C>T; p.P90S; 12:55841142-55841142	skin	malignant_melanoma	Substitution - Missense
c.1444T>A; p.S482T; 12:55837119-55837119	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.311G>A; p.W104*; 12:55840876-55840876	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.596G>A; p.G199E; 12:55839666-55839666	skin	malignant_melanoma	Substitution - Missense
c.1043G>T; p.W348L; 12:55837860-55837860	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.819C>A; p.P273P; 12:55838682-55838682	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1392T>C; p.N464N; 12:55837171-55837171	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.282G>T; p.K94N; 12:55841128-55841128	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.902G>A; p.R301H; 12:55838001-55838001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.117G>A; p.Q39Q; 12:55842409-55842409	breast	carcinoma	Substitution - coding silent
c.715C>T; p.P239S; 12:55839547-55839547	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.713G>A; p.R238Q; 12:55839549-55839549	central_nervous_system; brain	glioma	Substitution - Missense
c.343A>T; p.N115Y; 12:55840844-55840844	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.645C>T; p.G215G; 12:55839617-55839617	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1157G>A; p.W386*; 12:55837586-55837586	skin	malignant_melanoma	Substitution - Nonsense
c.1034G>A; p.R345Q; 12:55837869-55837869	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1034G>A; p.R345Q; 12:55837869-55837869	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1034G>A; p.R345Q; 12:55837869-55837869	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1034G>A; p.R345Q; 12:55837869-55837869	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.960G>A; p.P320P; 12:55837943-55837943	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.154G>T; p.D52Y; 12:55842372-55842372	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1292C>A; p.A431D; 12:55837271-55837271	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1110C>G; p.P370P; 12:55837633-55837633	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1273G>A; p.V425M; 12:55837290-55837290	liver	carcinoma	Substitution - Missense
c.1273G>A; p.V425M; 12:55837290-55837290	liver	carcinoma	Substitution - Missense
c.1263_1265delGTT; p.L421delL; 12:55837298-55837300	ovary	carcinoma; serous_carcinoma	Deletion - In frame
c.454G>A; p.A152T; 12:55840733-55840733	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454G>A; p.A152T; 12:55840733-55840733	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.333C>T; p.F111F; 12:55840854-55840854	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.224C>G; p.A75G; 12:55841186-55841186	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.437_449del13; p.E146fs*55; 12:55840738-55840750	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.947C>T; p.S316L; 12:55837956-55837956	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.265G>A; p.D89N; 12:55841145-55841145	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1068G>A; p.K356K; 12:55837675-55837675	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.388C>T; p.R130C; 12:55840799-55840799	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.171G>T; p.L57L; 12:55842355-55842355	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.75G>T; p.E25D; 12:55842756-55842756	breast	carcinoma	Substitution - Missense
c.970T>C; p.F324L; 12:55837933-55837933	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1028C>T; p.S343L; 12:55837875-55837875	skin; mucosal	malignant_melanoma	Substitution - Missense
c.985C>G; p.L329V; 12:55837918-55837918	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.696A>G; p.P232P; 12:55839566-55839566	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.38C>T; p.P13L; 12:55842793-55842793	liver	carcinoma	Substitution - Missense
c.38C>T; p.P13L; 12:55842793-55842793	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1152C>T; p.L384L; 12:55837591-55837591	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.796G>A; p.E266K; 12:55838705-55838705	skin	malignant_melanoma	Substitution - Missense
c.1511C>A; p.T504N; 12:55837052-55837052	skin	malignant_melanoma	Substitution - Missense
c.1475G>A; p.G492D; 12:55837088-55837088	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.883G>A; p.A295T; 12:55838618-55838618	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1223G>A; p.R408Q; 12:55837340-55837340	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1223G>A; p.R408Q; 12:55837340-55837340	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1076G>A; p.R359H; 12:55837667-55837667	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.856C>A; p.P286T; 12:55838645-55838645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.80C>T; p.A27V; 12:55842751-55842751	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.80C>T; p.A27V; 12:55842751-55842751	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.790G>A; p.D264N; 12:55838711-55838711	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.407G>A; p.W136*; 12:55840780-55840780	skin	malignant_melanoma	Substitution - Nonsense
c.176C>A; p.A59D; 12:55841234-55841234	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1213G>A; p.E405K; 12:55837350-55837350	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.706G>A; p.G236S; 12:55839556-55839556	skin	malignant_melanoma	Substitution - Missense
c.500C>T; p.S167F; 12:55840687-55840687	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.580G>A; p.E194K; 12:55839682-55839682	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1362G>A; p.Q454Q; 12:55837201-55837201	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.866G>A; p.C289Y; 12:55838635-55838635	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.929A>G; p.D310G; 12:55837974-55837974	skin	malignant_melanoma	Substitution - Missense
c.191C>G; p.S64C; 12:55841219-55841219	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1194C>T; p.S398S; 12:55837369-55837369	skin	malignant_melanoma	Substitution - coding silent
c.200C>A; p.P67Q; 12:55841210-55841210	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database