Entrez Gene

Basic Information
Gene ID	4320
Name	MMP11

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1158G>A; p.P386P; 22:23782308-23782308	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1455C>T; p.N485N; 22:23783532-23783532	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.332C>T; p.T111I; 22:23779410-23779410	ovary	other; neoplasm	Substitution - Missense
c.1287G>A; p.W429*; 22:23782437-23782437	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1223A>G; p.Y408C; 22:23782373-23782373	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.711C>T; p.Y237Y; 22:23780953-23780953	prostate	carcinoma	Substitution - coding silent
c.483-1G>T; p.?; 22:23780581-23780581	stomach	carcinoma; adenocarcinoma	Unknown
c.496G>A; p.D166N; 22:23780595-23780595	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1368G>A; p.W456*; 22:23783445-23783445	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.939G>A; p.A313A; 22:23781273-23781273	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.307G>A; p.G103R; 22:23779385-23779385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.665G>A; p.G222E; 22:23780907-23780907	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.414C>T; p.S138S; 22:23780434-23780434	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.184G>T; p.A62S; 22:23779262-23779262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.185C>T; p.A62V; 22:23779263-23779263	skin	malignant_melanoma	Substitution - Missense
c.1200C>G; p.I400M; 22:23782350-23782350	liver	carcinoma	Substitution - Missense
c.1200C>G; p.I400M; 22:23782350-23782350	liver	carcinoma	Substitution - Missense
c.603C>T; p.I201I; 22:23780702-23780702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.447C>T; p.H149H; 22:23780467-23780467	breast	carcinoma	Substitution - coding silent
c.1460T>C; p.F487S; 22:23783537-23783537	skin	malignant_melanoma	Substitution - Missense
c.392C>T; p.A131V; 22:23780412-23780412	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.448G>C; p.E150Q; 22:23780468-23780468	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1410C>T; p.P470P; 22:23783487-23783487	skin	malignant_melanoma	Substitution - coding silent
c.1186G>A; p.E396K; 22:23782336-23782336	breast	carcinoma	Substitution - Missense
c.1410C>T; p.P470P; 22:23783487-23783487	skin	malignant_melanoma	Substitution - coding silent
c.1073A>G; p.Q358R; 22:23781407-23781407	thyroid	other; neoplasm	Substitution - Missense
c.445C>T; p.H149Y; 22:23780465-23780465	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.421A>C; p.T141P; 22:23780441-23780441	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.294C>T; p.F98F; 22:23779372-23779372	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.445C>T; p.H149Y; 22:23780465-23780465	urinary_tract; bladder	carcinoma	Substitution - Missense
c.343C>T; p.L115F; 22:23780363-23780363	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.562G>T; p.E188*; 22:23780661-23780661	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1098C>T; p.D366D; 22:23782248-23782248	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.210G>A; p.R70R; 22:23779288-23779288	skin; arm	malignant_melanoma	Substitution - coding silent
c.210G>A; p.R70R; 22:23779288-23779288	skin; arm	malignant_melanoma	Substitution - coding silent
c.550A>G; p.K184E; 22:23780649-23780649	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1141G>A; p.G381S; 22:23782291-23782291	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1352G>A; p.R451H; 22:23783429-23783429	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.949T>C; p.W317R; 22:23781283-23781283	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.209G>A; p.R70Q; 22:23779287-23779287	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.209G>T; p.R70L; 22:23779287-23779287	skin; arm	malignant_melanoma	Substitution - Missense
c.209G>T; p.R70L; 22:23779287-23779287	skin; arm	malignant_melanoma	Substitution - Missense
c.1183C>T; p.P395S; 22:23782333-23782333	skin	malignant_melanoma	Substitution - Missense
c.1183C>T; p.P395S; 22:23782333-23782333	skin	malignant_melanoma	Substitution - Missense
c.1039T>G; p.F347V; 22:23781373-23781373	skin	malignant_melanoma	Substitution - Missense
c.187C>T; p.P63S; 22:23779265-23779265	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1123G>A; p.A375T; 22:23782273-23782273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.953G>A; p.R318H; 22:23781287-23781287	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232C>T; p.P78S; 22:23779310-23779310	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.704C>T; p.A235V; 22:23780946-23780946	skin; face	malignant_melanoma	Substitution - Missense
c.1462C>T; p.L488F; 22:23783539-23783539	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.635T>C; p.V212A; 22:23780877-23780877	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.891C>A; p.S297S; 22:23781225-23781225	skin	malignant_melanoma	Substitution - coding silent
c.1121C>T; p.P374L; 22:23782271-23782271	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1121C>T; p.P374L; 22:23782271-23782271	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.897C>T; p.D299D; 22:23781231-23781231	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.308G>T; p.G103V; 22:23779386-23779386	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1033G>A; p.A345T; 22:23781367-23781367	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.924C>A; p.L308L; 22:23781258-23781258	ovary	other; neoplasm	Substitution - coding silent
c.1442_1443CC>TT; p.A481V; 22:23783519-23783520	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.465C>T; p.I155I; 22:23780485-23780485	skin	malignant_melanoma	Substitution - coding silent
c.478G>A; p.A160T; 22:23780498-23780498	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.478G>A; p.A160T; 22:23780498-23780498	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	thyroid	other; neoplasm	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.A38V; 22:23779191-23779191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.324G>T; p.T108T; 22:23779402-23779402	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.952C>T; p.R318C; 22:23781286-23781286	ovary	other; neoplasm	Substitution - Missense
c.779C>T; p.P260L; 22:23781021-23781021	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1348C>A; p.L450M; 22:23783425-23783425	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1074A>T; p.Q358H; 22:23781408-23781408	thyroid	other; neoplasm	Substitution - Missense
c.574C>T; p.H192Y; 22:23780673-23780673	skin	malignant_melanoma	Substitution - Missense
c.574C>T; p.H192Y; 22:23780673-23780673	skin	malignant_melanoma	Substitution - Missense
c.959G>A; p.R320H; 22:23781293-23781293	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.574C>T; p.H192Y; 22:23780673-23780673	skin	malignant_melanoma	Substitution - Missense
c.346C>T; p.R116W; 22:23780366-23780366	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.194C>T; p.T65M; 22:23779272-23779272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.502C>T; p.L168L; 22:23780601-23780601	skin	malignant_melanoma	Substitution - coding silent
c.1247G>A; p.R416Q; 22:23782397-23782397	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.139G>A; p.G47R; 22:23779217-23779217	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.250G>A; p.D84N; 22:23779328-23779328	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.641C>T; p.A214V; 22:23780883-23780883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1292G>T; p.G431V; 22:23782442-23782442	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1354G>T; p.G452C; 22:23783431-23783431	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.499G>T; p.D167Y; 22:23780598-23780598	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1229G>A; p.R410H; 22:23782379-23782379	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1229G>A; p.R410H; 22:23782379-23782379	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.280C>T; p.R94*; 22:23779358-23779358	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Nonsense
c.301T>C; p.S101P; 22:23779379-23779379	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1235A>C; p.H412P; 22:23782385-23782385	breast	carcinoma	Substitution - Missense
c.579C>T; p.F193F; 22:23780678-23780678	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1055G>T; p.G352V; 22:23781389-23781389	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1068C>T; p.F356F; 22:23781402-23781402	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.249C>T; p.P83P; 22:23779327-23779327	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.267G>C; p.L89L; 22:23779345-23779345	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.267G>C; p.L89L; 22:23779345-23779345	breast	carcinoma	Substitution - coding silent
c.1427A>G; p.D476G; 22:23783504-23783504	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.249C>G; p.P83P; 22:23779327-23779327	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.839A>G; p.N280S; 22:23781081-23781081	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1323G>C; p.Q441H; 22:23782473-23782473	breast	carcinoma	Substitution - Missense
c.1411C>T; p.R471C; 22:23783488-23783488	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259G>A; p.D87N; 22:23779337-23779337	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.754G>A; p.G252S; 22:23780996-23780996	thyroid	carcinoma	Substitution - Missense
c.275G>A; p.R92H; 22:23779353-23779353	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense

The somatic mutations from COSMIC database