Entrez Gene

Basic Information
Gene ID	4314
Name	MMP3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.210C>T; p.F70F; 11:102842812-102842812	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.836C>T; p.P279L; 11:102840207-102840207	skin	malignant_melanoma	Substitution - Missense
c.97C>T; p.L33F; 11:102843450-102843450	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.185A>T; p.K62I; 11:102842837-102842837	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.563G>T; p.G188V; 11:102842216-102842216	breast	carcinoma	Substitution - Missense
c.133A>G; p.K45E; 11:102842889-102842889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.604C>A; p.Q202K; 11:102842175-102842175	breast	carcinoma	Substitution - Missense
c.1191G>A; p.K397K; 11:102838589-102838589	skin	malignant_melanoma	Substitution - coding silent
c.1180G>C; p.D394H; 11:102838600-102838600	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1018G>T; p.V340L; 11:102839161-102839161	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.133A>G; p.K45E; 11:102842889-102842889	breast	carcinoma	Substitution - Missense
c.1018G>A; p.V340M; 11:102839161-102839161	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.754T>C; p.S252P; 11:102840465-102840465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.499+2T>C; p.?; 11:102842429-102842429	stomach	adenocarcinoma	Unknown
c.799C>T; p.P267S; 11:102840244-102840244	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.283C>T; p.P95S; 11:102842739-102842739	skin	malignant_melanoma	Substitution - Missense
c.243C>T; p.S81S; 11:102842779-102842779	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1106G>A; p.R369Q; 11:102838674-102838674	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1391A>C; p.K464T; 11:102836169-102836169	skin	malignant_melanoma	Substitution - Missense
c.791G>A; p.G264E; 11:102840252-102840252	skin	malignant_melanoma	Substitution - Missense
c.320C>T; p.P107L; 11:102842702-102842702	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.219G>A; p.L73L; 11:102842803-102842803	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1026C>A; p.A342A; 11:102839153-102839153	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1009C>T; p.P337S; 11:102839170-102839170	skin	malignant_melanoma	Substitution - Missense
c.798C>A; p.P266P; 11:102840245-102840245	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.601G>A; p.E201K; 11:102842178-102842178	skin	malignant_melanoma	Substitution - Missense
c.1191G>T; p.K397N; 11:102838589-102838589	breast	carcinoma	Substitution - Missense
c.190delA; p.I64fs*12; 11:102842832-102842832	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.190delA; p.I64fs*12; 11:102842832-102842832	thyroid	carcinoma; medullary_carcinoma	Deletion - Frameshift
c.741T>G; p.T247T; 11:102840478-102840478	ovary	other; neoplasm	Substitution - coding silent
c.262C>T; p.R88C; 11:102842760-102842760	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1080C>A; p.F360L; 11:102838700-102838700	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1234G>C; p.D412H; 11:102837397-102837397	breast	carcinoma	Substitution - Missense
c.1124G>A; p.G375D; 11:102838656-102838656	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.391G>C; p.D131H; 11:102842539-102842539	liver	carcinoma	Substitution - Missense
c.546C>A; p.A182A; 11:102842233-102842233	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1047G>A; p.K349K; 11:102839132-102839132	skin	malignant_melanoma	Substitution - coding silent
c.1047G>A; p.K349K; 11:102839132-102839132	skin	malignant_melanoma	Substitution - coding silent
c.806C>T; p.S269F; 11:102840237-102840237	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.806C>T; p.S269F; 11:102840237-102840237	skin	malignant_melanoma	Substitution - Missense
c.806C>T; p.S269F; 11:102840237-102840237	skin	malignant_melanoma	Substitution - Missense
c.139G>T; p.D47Y; 11:102842883-102842883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1347C>A; p.F449L; 11:102836213-102836213	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326G>A; p.W109*; 11:102842696-102842696	skin	malignant_melanoma	Substitution - Nonsense
c.288T>C; p.D96D; 11:102842734-102842734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.288T>C; p.D96D; 11:102842734-102842734	breast	carcinoma	Substitution - coding silent
c.669C>T; p.S223S; 11:102840550-102840550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.410C>T; p.A137V; 11:102842520-102842520	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.435T>A; p.T145T; 11:102842495-102842495	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1153G>A; p.V385M; 11:102838627-102838627	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1153G>A; p.V385M; 11:102838627-102838627	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.987C>T; p.I329I; 11:102839192-102839192	skin	malignant_melanoma	Substitution - coding silent
c.1196A>G; p.K399R; 11:102838584-102838584	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.831G>C; p.T277T; 11:102840212-102840212	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.652C>T; p.H218Y; 11:102840567-102840567	skin	malignant_melanoma	Substitution - Missense
c.268C>T; p.P90S; 11:102842754-102842754	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.568_569GG>AA; p.G190K; 11:102842210-102842211	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.470C>G; p.A157G; 11:102842460-102842460	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.460G>A; p.E154K; 11:102842470-102842470	skin	malignant_melanoma	Substitution - Missense
c.663C>T; p.G221G; 11:102840556-102840556	skin	malignant_melanoma	Substitution - coding silent
c.1229+2T>C; p.?; 11:102838549-102838549	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.946C>T; p.R316C; 11:102839233-102839233	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.946C>T; p.R316C; 11:102839233-102839233	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.946C>T; p.R316C; 11:102839233-102839233	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.946C>T; p.R316C; 11:102839233-102839233	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.946C>T; p.R316C; 11:102839233-102839233	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.816C>T; p.T272T; 11:102840227-102840227	skin	malignant_melanoma	Substitution - coding silent
c.820delC; p.L274fs*29; 11:102840223-102840223	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.122A>G; p.Y41C; 11:102842900-102842900	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.783C>T; p.S261S; 11:102840436-102840436	skin	malignant_melanoma	Substitution - coding silent
c.122A>G; p.Y41C; 11:102842900-102842900	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.569G>T; p.G190V; 11:102842210-102842210	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.783C>T; p.S261S; 11:102840436-102840436	skin	malignant_melanoma	Substitution - coding silent
c.499G>A; p.E167K; 11:102842431-102842431	thyroid	other; neoplasm	Substitution - Missense
c.1186G>A; p.E396K; 11:102838594-102838594	skin	malignant_melanoma	Substitution - Missense
c.673G>T; p.G225C; 11:102840546-102840546	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.83A>G; p.D28G; 11:102843464-102843464	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.891T>C; p.D297D; 11:102840152-102840152	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1254G>A; p.M418I; 11:102837377-102837377	skin	malignant_melanoma	Substitution - Missense
c.1353T>C; p.T451T; 11:102836207-102836207	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1254G>A; p.M418I; 11:102837377-102837377	skin	malignant_melanoma	Substitution - Missense
c.1000C>T; p.P334S; 11:102839179-102839179	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.542T>A; p.L181*; 11:102842237-102842237	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Nonsense
c.1033G>A; p.E345K; 11:102839146-102839146	skin	malignant_melanoma	Substitution - Missense
c.984G>T; p.L328F; 11:102839195-102839195	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.831G>A; p.T277T; 11:102840212-102840212	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.193C>T; p.R65*; 11:102842829-102842829	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1086T>C; p.A362A; 11:102838694-102838694	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.811G>A; p.E271K; 11:102840232-102840232	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1048G>A; p.D350N; 11:102839131-102839131	skin	malignant_melanoma	Substitution - Missense
c.351G>A; p.R117R; 11:102842579-102842579	skin	malignant_melanoma	Substitution - coding silent
c.415A>G; p.K139E; 11:102842515-102842515	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.628A>T; p.T210S; 11:102840591-102840591	thyroid	carcinoma	Substitution - Missense
c.1201T>C; p.Y401H; 11:102838579-102838579	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.491C>T; p.A164V; 11:102842439-102842439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.33C>T; p.C11C; 11:102843514-102843514	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.951A>G; p.K317K; 11:102839228-102839228	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.351-1G>T; p.?; 11:102842580-102842580	lung	carcinoma; adenocarcinoma	Unknown
c.1261G>A; p.G421S; 11:102837370-102837370	pancreas	carcinoma	Substitution - Missense
c.727C>T; p.L243F; 11:102840492-102840492	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.984G>A; p.L328L; 11:102839195-102839195	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.947G>A; p.R316H; 11:102839232-102839232	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.947G>A; p.R316H; 11:102839232-102839232	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.274T>C; p.C92R; 11:102842748-102842748	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1128C>T; p.I376I; 11:102838652-102838652	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.412C>T; p.L138L; 11:102842518-102842518	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.93G>A; p.M31I; 11:102843454-102843454	skin	malignant_melanoma	Substitution - Missense
c.1025C>A; p.A342D; 11:102839154-102839154	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.132C>T; p.L44L; 11:102842890-102842890	large_intestine; rectum	adenoma	Substitution - coding silent
c.1403C>T; p.T468I; 11:102836157-102836157	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.216A>C; p.G72G; 11:102842806-102842806	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1403C>T; p.T468I; 11:102836157-102836157	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1378C>T; p.P460S; 11:102836182-102836182	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.820_821insC; p.L274fs*18; 11:102840222-102840223	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.228G>T; p.T76T; 11:102842794-102842794	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.321G>A; p.P107P; 11:102842701-102842701	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1026C>T; p.A342A; 11:102839153-102839153	lung	carcinoma	Substitution - coding silent
c.572T>G; p.I191S; 11:102842207-102842207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.572T>G; p.I191S; 11:102842207-102842207	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.419T>G; p.V140G; 11:102842511-102842511	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.802G>T; p.D268Y; 11:102840241-102840241	skin	malignant_melanoma	Substitution - Missense
c.1241A>T; p.K414M; 11:102837390-102837390	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1144C>T; p.P382S; 11:102838636-102838636	skin	malignant_melanoma	Substitution - Missense
c.699A>G; p.E233E; 11:102840520-102840520	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1241A>T; p.K414M; 11:102837390-102837390	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1143C>T; p.F381F; 11:102838637-102838637	skin	malignant_melanoma	Substitution - coding silent
c.1143C>T; p.F381F; 11:102838637-102838637	skin	malignant_melanoma	Substitution - coding silent
c.382G>A; p.D128N; 11:102842548-102842548	skin	malignant_melanoma	Substitution - Missense
c.953C>A; p.S318Y; 11:102839226-102839226	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database