Entrez Gene

Basic Information
Gene ID	4215
Name	MAP3K3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1667C>T; p.T556I; 17:63693563-63693563	stomach	adenocarcinoma	Substitution - Missense
c.528A>C; p.S176S; 17:63681791-63681791	thyroid	other; neoplasm	Substitution - coding silent
c.1156C>T; p.R386C; 17:63690356-63690356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1412G>A; p.R471Q; 17:63691800-63691800	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.387T>C; p.S129S; 17:63666945-63666945	skin	malignant_melanoma	Substitution - coding silent
c.1246C>A; p.L416I; 17:63691135-63691135	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1696C>T; p.P566S; 17:63693592-63693592	skin	malignant_melanoma	Substitution - Missense
c.474C>T; p.P158P; 17:63667032-63667032	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1475-1G>A; p.?; 17:63692241-63692241	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.885_886insC; p.R297fs*85; 17:63689557-63689558	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.670T>C; p.L224L; 17:63685550-63685550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1365G>A; p.L455L; 17:63691753-63691753	pancreas	carcinoma	Substitution - coding silent
c.896G>A; p.R299Q; 17:63689568-63689568	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1840G>C; p.E614Q; 17:63693736-63693736	breast	carcinoma	Substitution - Missense
c.1698G>A; p.P566P; 17:63693594-63693594	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.166C>G; p.R56G; 17:63646073-63646073	skin	malignant_melanoma	Substitution - Missense
c.320T>C; p.L107S; 17:63657846-63657846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.532delC; p.P179fs*39; 17:63681795-63681795	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.532delC; p.P179fs*39; 17:63681795-63681795	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.833G>A; p.R278H; 17:63688843-63688843	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.389C>T; p.S130F; 17:63666947-63666947	skin; extremity	malignant_melanoma	Substitution - Missense
c.1047G>A; p.R349R; 17:63689719-63689719	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.704C>T; p.A235V; 17:63685584-63685584	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.649C>T; p.L217L; 17:63685529-63685529	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.730C>T; p.R244*; 17:63688546-63688546	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.132C>T; p.D44D; 17:63646039-63646039	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.365C>T; p.S122F; 17:63657891-63657891	skin	malignant_melanoma	Substitution - Missense
c.99C>A; p.N33K; 17:63632775-63632775	oesophagus	carcinoma	Substitution - Missense
c.501C>T; p.V167V; 17:63667059-63667059	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.871+1G>A; p.?; 17:63688882-63688882	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.37G>A; p.D13N; 17:63632713-63632713	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.7G>A; p.E3K; 17:63632683-63632683	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1281C>T; p.Y427Y; 17:63691170-63691170	skin	malignant_melanoma	Substitution - coding silent
c.374G>T; p.R125I; 17:63657900-63657900	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1012G>C; p.A338P; 17:63689684-63689684	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.157G>A; p.G53R; 17:63646064-63646064	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.691T>C; p.L231L; 17:63685571-63685571	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1790G>A; p.R597Q; 17:63693686-63693686	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1268G>A; p.R423H; 17:63691157-63691157	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1841A>T; p.E614V; 17:63693737-63693737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.520C>T; p.R174*; 17:63681783-63681783	pancreas	carcinoma	Substitution - Nonsense
c.396C>T; p.P132P; 17:63666954-63666954	skin	malignant_melanoma	Substitution - coding silent
c.1161A>C; p.E387D; 17:63690361-63690361	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.524G>A; p.S175N; 17:63681787-63681787	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.728C>T; p.S243L; 17:63688544-63688544	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1272C>T; p.I424I; 17:63691161-63691161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.446G>A; p.G149E; 17:63667004-63667004	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.685C>T; p.Q229*; 17:63685565-63685565	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.480C>T; p.P160P; 17:63667038-63667038	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.572G>A; p.R191Q; 17:63681835-63681835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.815G>A; p.G272D; 17:63688825-63688825	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.441C>T; p.S147S; 17:63666999-63666999	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1400G>A; p.R467Q; 17:63691788-63691788	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.529C>T; p.P177S; 17:63681792-63681792	thyroid	carcinoma	Substitution - Missense
c.94A>G; p.K32E; 17:63632770-63632770	urinary_tract; bladder	carcinoma	Substitution - Missense
c.94A>G; p.K32E; 17:63632770-63632770	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1723G>A; p.A575T; 17:63693619-63693619	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1593C>A; p.P531P; 17:63692360-63692360	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.844T>C; p.S282P; 17:63688854-63688854	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1823G>A; p.R608H; 17:63693719-63693719	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.6C>T; p.D2D; 17:63632682-63632682	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.829C>T; p.R277W; 17:63688839-63688839	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.829C>T; p.R277W; 17:63688839-63688839	prostate	carcinoma	Substitution - Missense
c.1444A>T; p.S482C; 17:63691832-63691832	skin	malignant_melanoma	Substitution - Missense
c.260A>G; p.N87S; 17:63652649-63652649	skin	malignant_melanoma	Substitution - Missense
c.1212G>T; p.K404N; 17:63690412-63690412	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.929C>T; p.P310L; 17:63689601-63689601	skin	malignant_melanoma	Substitution - Missense
c.1498G>A; p.A500T; 17:63692265-63692265	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.759C>T; p.D253D; 17:63688575-63688575	central_nervous_system; brain	glioma	Substitution - coding silent
c.224C>T; p.T75I; 17:63652613-63652613	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1790G>T; p.R597L; 17:63693686-63693686	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.895C>T; p.R299W; 17:63689567-63689567	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.550G>A; p.E184K; 17:63681813-63681813	thyroid	carcinoma	Substitution - Missense
c.1385C>A; p.T462K; 17:63691773-63691773	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1151C>T; p.T384M; 17:63690351-63690351	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1789C>T; p.R597W; 17:63693685-63693685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1660G>A; p.G554S; 17:63693556-63693556	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1789C>T; p.R597W; 17:63693685-63693685	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1503G>A; p.G501G; 17:63692270-63692270	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.133G>A; p.V45I; 17:63646040-63646040	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.133G>A; p.V45I; 17:63646040-63646040	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1684A>T; p.T562S; 17:63693580-63693580	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.280C>G; p.L94V; 17:63657806-63657806	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1566G>A; p.T522T; 17:63692333-63692333	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.791A>G; p.Q264R; 17:63688801-63688801	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1528delG; p.A510fs*25; 17:63692295-63692295	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1198_1199CC>TT; p.P400F; 17:63690398-63690399	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.496T>C; p.S166P; 17:63667054-63667054	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1409C>T; p.T470M; 17:63691797-63691797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.536C>T; p.P179L; 17:63681799-63681799	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1722C>T; p.A574A; 17:63693618-63693618	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1825C>A; p.Q609K; 17:63693721-63693721	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1538G>A; p.R513H; 17:63692305-63692305	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.803A>G; p.K268R; 17:63688813-63688813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.779-2A>T; p.?; 17:63688787-63688787	lung	carcinoma; small_cell_carcinoma	Unknown
c.1350G>C; p.S450S; 17:63691738-63691738	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - coding silent
c.779-2A>T; p.?; 17:63688787-63688787	lung	carcinoma; small_cell_carcinoma	Unknown
c.533C>T; p.P178L; 17:63681796-63681796	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.496T>G; p.S166A; 17:63667054-63667054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.503G>C; p.S168T; 17:63681766-63681766	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.503G>C; p.S168T; 17:63681766-63681766	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1317G>C; p.L439L; 17:63691206-63691206	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.905A>G; p.Q302R; 17:63689577-63689577	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.P216S; 17:63685526-63685526	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1088G>T; p.R363L; 17:63690288-63690288	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.937C>G; p.R313G; 17:63689609-63689609	skin	malignant_melanoma	Substitution - Missense
c.1088G>T; p.R363L; 17:63690288-63690288	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.167G>A; p.R56Q; 17:63646074-63646074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1301G>T; p.R434L; 17:63691190-63691190	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.664A>T; p.N222Y; 17:63685544-63685544	thyroid	carcinoma	Substitution - Missense
c.1395G>A; p.V465V; 17:63691783-63691783	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.1502G>A; p.G501E; 17:63692269-63692269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.636+1G>A; p.?; 17:63681900-63681900	stomach	carcinoma; adenocarcinoma	Unknown
c.88A>T; p.T30S; 17:63632764-63632764	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.72G>T; p.R24R; 17:63632748-63632748	liver	carcinoma	Substitution - coding silent
c.126+1_126+2delGT; p.?; 17:63632803-63632804	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.137G>A; p.R46K; 17:63646044-63646044	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.721C>T; p.R241W; 17:63688537-63688537	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1144G>A; p.V382M; 17:63690344-63690344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.640C>T; p.L214L; 17:63685520-63685520	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.176C>T; p.A59V; 17:63652565-63652565	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database