Entrez Gene

Basic Information
Gene ID	3320
Name	HSP90AA1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.2053G>A; p.E685K; 14:102083102-102083102	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1534G>A; p.D512N; 14:102083963-102083963	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1534G>A; p.D512N; 14:102083963-102083963	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2076_2077CC>TT; p.L693F; 14:102083078-102083079	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1322A>G; p.D441G; 14:102084706-102084706	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1446C>T; p.N482N; 14:102084466-102084466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1697A>C; p.N566T; 14:102083800-102083800	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1923C>A; p.I641I; 14:102083232-102083232	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.998C>T; p.S333F; 14:102085329-102085329	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1876A>G; p.N626D; 14:102083279-102083279	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1263A>C; p.R421S; 14:102084765-102084765	oesophagus	carcinoma	Substitution - Missense
c.433C>T; p.Q145*; 14:102086312-102086312	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2494G>T; p.A832S; 14:102081783-102081783	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1102G>T; p.E368*; 14:102084926-102084926	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1538C>T; p.S513L; 14:102083959-102083959	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.243C>A; p.L81L; 14:102101998-102101998	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1099A>G; p.K367E; 14:102084929-102084929	liver	carcinoma	Substitution - Missense
c.1099A>G; p.K367E; 14:102084929-102084929	liver	carcinoma	Substitution - Missense
c.2356A>G; p.I786V; 14:102082210-102082210	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2391C>G; p.G797G; 14:102082175-102082175	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.492G>C; p.E164D; 14:102086253-102086253	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.261C>T; p.H87H; 14:102101980-102101980	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.261C>T; p.H87H; 14:102101980-102101980	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.539A>C; p.K180T; 14:102086114-102086114	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.539A>C; p.K180T; 14:102086114-102086114	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.539A>C; p.K180T; 14:102086114-102086114	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.483G>C; p.S161S; 14:102086262-102086262	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1519_1520insTC; p.R508fs*5; 14:102083977-102083978	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.112C>A; p.P38T; 14:102139293-102139293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.656G>A; p.G219E; 14:102085997-102085997	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.656G>A; p.G219E; 14:102085997-102085997	urinary_tract; bladder	carcinoma	Substitution - Missense
c.981G>C; p.E327D; 14:102085346-102085346	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.218C>A; p.S73Y; 14:102102023-102102023	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2062delA; p.T688fs*10; 14:102083093-102083093	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.282C>T; p.T94T; 14:102101959-102101959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2062delA; p.T688fs*10; 14:102083093-102083093	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1108G>C; p.E370Q; 14:102084920-102084920	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2528G>T; p.G843V; 14:102081749-102081749	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1608G>T; p.K536N; 14:102083889-102083889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1863G>C; p.K621N; 14:102083292-102083292	breast	carcinoma	Substitution - Missense
c.1839C>T; p.I613I; 14:102083559-102083559	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.164C>A; p.P55H; 14:102102077-102102077	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1778G>T; p.G593V; 14:102083620-102083620	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1998C>T; p.V666V; 14:102083157-102083157	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1778G>T; p.G593V; 14:102083620-102083620	stomach	adenocarcinoma	Substitution - Missense
c.1089A>C; p.K363N; 14:102084939-102084939	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.513T>A; p.I171I; 14:102086232-102086232	skin	malignant_melanoma	Substitution - coding silent
c.2093A>C; p.K698T; 14:102083062-102083062	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1096_1099delGAAA; p.E366fs*72; 14:102084929-102084932	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.1214A>C; p.K405T; 14:102084814-102084814	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2283C>T; p.D761D; 14:102082283-102082283	skin	malignant_melanoma	Substitution - coding silent
c.1900C>T; p.R634W; 14:102083255-102083255	skin	malignant_melanoma	Substitution - Missense
c.1387C>T; p.L463L; 14:102084525-102084525	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.450G>A; p.Q150Q; 14:102086295-102086295	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1775C>G; p.S592C; 14:102083623-102083623	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>A; p.P301H; 14:102085425-102085425	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1651G>A; p.E551K; 14:102083846-102083846	oesophagus	carcinoma	Substitution - Missense
c.2057A>G; p.K686R; 14:102083098-102083098	thyroid	other; neoplasm	Substitution - Missense
c.2100A>G; p.I700M; 14:102083055-102083055	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2515C>T; p.P839S; 14:102081762-102081762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1651G>T; p.E551*; 14:102083846-102083846	skin	malignant_melanoma	Substitution - Nonsense
c.47_48CC>TT; p.S16F; 14:102139357-102139358	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.622G>T; p.D208Y; 14:102086031-102086031	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1105_1110delAAAGAA; p.K369_E370delKE; 14:102084918-102084923	liver	carcinoma	Deletion - In frame
c.1105_1110delAAAGAA; p.K369_E370delKE; 14:102084918-102084923	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.2248A>G; p.M750V; 14:102082318-102082318	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1937C>T; p.P646L; 14:102083218-102083218	ovary	other; neoplasm	Substitution - Missense
c.1561T>A; p.S521T; 14:102083936-102083936	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1051G>C; p.E351Q; 14:102084977-102084977	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.974T>C; p.I325T; 14:102085353-102085353	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.462G>C; p.L154F; 14:102086283-102086283	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2136C>T; p.N712N; 14:102082430-102082430	skin	malignant_melanoma	Substitution - coding silent
c.1414G>C; p.D472H; 14:102084498-102084498	urinary_tract; bladder	carcinoma	Substitution - Missense
c.339G>A; p.L113L; 14:102101902-102101902	ovary	other; neoplasm	Substitution - coding silent
c.1010G>C; p.G337A; 14:102085317-102085317	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1864G>A; p.D622N; 14:102083291-102083291	thyroid	carcinoma	Substitution - Missense
c.2137C>T; p.R713*; 14:102082429-102082429	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.1894C>T; p.R632C; 14:102083261-102083261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1026T>C; p.L342L; 14:102085301-102085301	oesophagus	carcinoma	Substitution - coding silent
c.2116G>A; p.E706K; 14:102083039-102083039	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1715A>T; p.H572L; 14:102083683-102083683	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1715A>T; p.H572L; 14:102083683-102083683	stomach	adenocarcinoma	Substitution - Missense
c.1377C>T; p.F459F; 14:102084535-102084535	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2417A>G; p.H806R; 14:102082149-102082149	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2132C>A; p.S711*; 14:102082434-102082434	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2423A>C; p.N808T; 14:102082143-102082143	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.420G>C; p.E140D; 14:102086325-102086325	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1302C>A; p.F434L; 14:102084726-102084726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1414G>A; p.D472N; 14:102084498-102084498	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1623delA; p.K541fs*3; 14:102083874-102083874	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1414G>A; p.D472N; 14:102084498-102084498	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.60G>A; p.R20R; 14:102139345-102139345	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1205T>C; p.I402T; 14:102084823-102084823	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.632T>C; p.L211P; 14:102086021-102086021	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1096_1098delGAA; p.E366delE; 14:102084930-102084932	breast	carcinoma	Deletion - In frame
c.499C>G; p.L167V; 14:102086246-102086246	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.470A>C; p.N157T; 14:102086275-102086275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.980A>G; p.E327G; 14:102085347-102085347	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.980A>G; p.E327G; 14:102085347-102085347	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.980A>G; p.E327G; 14:102085347-102085347	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1204_1205insAGA; p.K401_I402insK; 14:102084823-102084824	endometrium	carcinoma; endometrioid_carcinoma	Insertion - In frame
c.845A>G; p.Y282C; 14:102085808-102085808	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.37C>T; p.P13S; 14:102139368-102139368	kidney	Wilms_tumour	Substitution - Missense
c.2164G>A; p.V722I; 14:102082402-102082402	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.199C>A; p.L67I; 14:102102042-102102042	breast	carcinoma	Substitution - Missense
c.1066G>T; p.E356*; 14:102084962-102084962	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1525G>T; p.G509W; 14:102083972-102083972	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1543G>A; p.D515N; 14:102083954-102083954	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2213C>A; p.A738D; 14:102082353-102082353	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2213C>A; p.A738D; 14:102082353-102082353	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1238A>G; p.N413S; 14:102084790-102084790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2561A>G; p.D854G; 14:102081716-102081716	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2039A>G; p.K680R; 14:102083116-102083116	urinary_tract; bladder	carcinoma	Substitution - Missense
c.95A>G; p.D32G; 14:102139310-102139310	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2150C>T; p.S717F; 14:102082416-102082416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1330G>A; p.D444N; 14:102084698-102084698	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1265A>G; p.N422S; 14:102084763-102084763	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.102G>A; p.L34L; 14:102139303-102139303	ovary	other; neoplasm	Substitution - coding silent
c.2250G>A; p.M750I; 14:102082316-102082316	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2463T>C; p.D821D; 14:102081814-102081814	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1852+10C>T; p.?; 14:102083536-102083536	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.967C>G; p.R323G; 14:102085360-102085360	prostate	carcinoma	Substitution - Missense
c.1619A>T; p.K540I; 14:102083878-102083878	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database