Entrez Gene

Basic Information
Gene ID	3164
Name	NR4A1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1205A>G; p.D402G; 12:52057103-52057103	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1349G>A; p.R450H; 12:52057247-52057247	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1032G>A; p.G344G; 12:52056519-52056519	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1091T>G; p.L364R; 12:52056578-52056578	skin	malignant_melanoma	Substitution - Missense
c.943C>T; p.R315W; 12:52056096-52056096	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1571T>G; p.V524G; 12:52058718-52058718	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.684G>A; p.T228T; 12:52055012-52055012	breast	carcinoma	Substitution - coding silent
c.1493T>C; p.V498A; 12:52057483-52057483	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.105G>A; p.M35I; 12:52054433-52054433	thyroid	other; neoplasm	Substitution - Missense
c.264A>C; p.T88T; 12:52054592-52054592	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.453C>G; p.L151L; 12:52054781-52054781	breast	carcinoma	Substitution - coding silent
c.366G>A; p.E122E; 12:52054694-52054694	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.337C>T; p.P113S; 12:52054665-52054665	skin	malignant_melanoma	Substitution - Missense
c.334T>C; p.Y112H; 12:52054662-52054662	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.768G>A; p.R256R; 12:52055096-52055096	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1454G>A; p.S485N; 12:52057444-52057444	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1092C>T; p.L364L; 12:52056579-52056579	skin	malignant_melanoma	Substitution - coding silent
c.51C>T; p.P17P; 12:52054379-52054379	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.913G>T; p.A305S; 12:52056066-52056066	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1494C>T; p.V498V; 12:52057484-52057484	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1684C>A; p.L562M; 12:52058831-52058831	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	breast	carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>A; p.L562M; 12:52058831-52058831	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.444G>T; p.P148P; 12:52054772-52054772	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1450G>T; p.D484Y; 12:52057440-52057440	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1617G>A; p.V539V; 12:52058764-52058764	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.52C>T; p.R18C; 12:52054380-52054380	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.894C>T; p.N298N; 12:52056047-52056047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1262C>T; p.A421V; 12:52057160-52057160	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1438G>A; p.G480R; 12:52057428-52057428	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1224C>G; p.D408E; 12:52057122-52057122	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.888G>A; p.Q296Q; 12:52056041-52056041	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.310G>A; p.E104K; 12:52054638-52054638	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.685G>A; p.A229T; 12:52055013-52055013	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1441G>T; p.D481Y; 12:52057431-52057431	oesophagus	carcinoma	Substitution - Missense
c.106G>C; p.D36H; 12:52054434-52054434	thyroid	other; neoplasm	Substitution - Missense
c.286_287insCTGCCT; p.S100_F101insAS; 12:52054614-52054615	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Insertion - In frame
c.1235G>T; p.G412V; 12:52057133-52057133	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.498T>G; p.T166T; 12:52054826-52054826	skin	malignant_melanoma	Substitution - coding silent
c.1034G>A; p.R345Q; 12:52056521-52056521	liver	carcinoma	Substitution - Missense
c.1034G>A; p.R345Q; 12:52056521-52056521	liver	carcinoma	Substitution - Missense
c.1323G>A; p.S441S; 12:52057221-52057221	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1509C>T; p.F503F; 12:52057499-52057499	breast	carcinoma	Substitution - coding silent
c.1424G>A; p.C475Y; 12:52057414-52057414	breast	carcinoma	Substitution - Missense
c.612G>A; p.Q204Q; 12:52054940-52054940	liver	carcinoma	Substitution - coding silent
c.1464C>T; p.A488A; 12:52057454-52057454	skin	malignant_melanoma	Substitution - coding silent
c.603C>A; p.S201R; 12:52054931-52054931	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.986C>T; p.A329V; 12:52056139-52056139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1456A>G; p.I486V; 12:52057446-52057446	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.174C>T; p.D58D; 12:52054502-52054502	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1544G>C; p.R515P; 12:52058691-52058691	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1507T>C; p.F503L; 12:52057497-52057497	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1446G>A; p.W482*; 12:52057436-52057436	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.470C>T; p.S157F; 12:52054798-52054798	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.947G>A; p.R316Q; 12:52056100-52056100	breast	carcinoma	Substitution - Missense
c.1109G>A; p.R370H; 12:52056596-52056596	urinary_tract; bladder	carcinoma	Substitution - Missense
c.947G>A; p.R316Q; 12:52056100-52056100	urinary_tract; bladder	carcinoma	Substitution - Missense
c.783T>G; p.G261G; 12:52055111-52055111	breast	carcinoma	Substitution - coding silent
c.883G>A; p.V295M; 12:52056036-52056036	oesophagus	carcinoma	Substitution - Missense
c.1374C>T; p.G458G; 12:52057364-52057364	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.450G>A; p.Q150Q; 12:52054778-52054778	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1539C>T; p.T513T; 12:52057529-52057529	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1314G>A; p.L438L; 12:52057212-52057212	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.394T>A; p.Y132N; 12:52054722-52054722	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.394T>A; p.Y132N; 12:52054722-52054722	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.656G>T; p.G219V; 12:52054984-52054984	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1579C>G; p.L527V; 12:52058726-52058726	thyroid	other; neoplasm	Substitution - Missense
c.112G>T; p.A38S; 12:52054440-52054440	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1500C>T; p.V500V; 12:52057490-52057490	skin	malignant_melanoma	Substitution - coding silent
c.1041C>G; p.G347G; 12:52056528-52056528	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1069C>T; p.P357S; 12:52056556-52056556	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.416C>T; p.P139L; 12:52054744-52054744	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.767G>A; p.R256Q; 12:52055095-52055095	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.767G>A; p.R256Q; 12:52055095-52055095	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.767G>A; p.R256Q; 12:52055095-52055095	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1263G>T; p.A421A; 12:52057161-52057161	prostate	adenoma	Substitution - coding silent
c.474C>T; p.F158F; 12:52054802-52054802	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1154C>G; p.S385C; 12:52056641-52056641	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.704C>T; p.P235L; 12:52055032-52055032	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1014A>G; p.R338R; 12:52056501-52056501	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.297C>T; p.A99A; 12:52054625-52054625	thyroid	other; neoplasm	Substitution - coding silent
c.884T>A; p.V295E; 12:52056037-52056037	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1154C>T; p.S385F; 12:52056641-52056641	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1307_1308ins56; p.L438fs*1; 12:52057205-52057206	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Insertion - Frameshift
c.1773C>A; p.I591I; 12:52058920-52058920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.766C>T; p.R256W; 12:52055094-52055094	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.437T>G; p.F146C; 12:52054765-52054765	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.475G>A; p.G159S; 12:52054803-52054803	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1562C>T; p.P521L; 12:52058709-52058709	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1058C>T; p.P353L; 12:52056545-52056545	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1058C>T; p.P353L; 12:52056545-52056545	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.876+5C>T; p.?; 12:52055209-52055209	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.1076C>A; p.A359D; 12:52056563-52056563	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1033C>T; p.R345W; 12:52056520-52056520	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1033C>T; p.R345W; 12:52056520-52056520	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1033C>T; p.R345W; 12:52056520-52056520	large_intestine; colon	carcinoma	Substitution - Missense
c.502G>A; p.E168K; 12:52054830-52054830	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1033C>T; p.R345W; 12:52056520-52056520	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.395A>G; p.Y132C; 12:52054723-52054723	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.395A>G; p.Y132C; 12:52054723-52054723	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1202G>A; p.G401E; 12:52057100-52057100	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1202G>A; p.G401E; 12:52057100-52057100	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1475C>T; p.S492F; 12:52057465-52057465	skin	malignant_melanoma	Substitution - Missense
c.1364C>G; p.S455C; 12:52057354-52057354	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.849A>G; p.T283T; 12:52055177-52055177	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1700C>T; p.T567I; 12:52058847-52058847	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.572C>T; p.S191F; 12:52054900-52054900	skin	malignant_melanoma	Substitution - Missense
c.292T>C; p.S98P; 12:52054620-52054620	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.870C>T; p.F290F; 12:52055198-52055198	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.486G>A; p.S162S; 12:52054814-52054814	liver	carcinoma	Substitution - coding silent
c.270G>A; p.S90S; 12:52054598-52054598	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.486G>A; p.S162S; 12:52054814-52054814	liver	carcinoma	Substitution - coding silent
c.1459C>A; p.L487M; 12:52057449-52057449	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1335G>T; p.E445D; 12:52057233-52057233	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3G>C; p.M1I; 12:52054331-52054331	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1134C>T; p.S378S; 12:52056621-52056621	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.877-7C>T; p.?; 12:52056023-52056023	lung	carcinoma; squamous_cell_carcinoma	Unknown

The somatic mutations from COSMIC database