Entrez Gene

Basic Information
Gene ID	3146
Name	HMGB1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.447G>A; p.A149A; 13:30462562-30462562	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.260_261insA; p.K88fs*21; 13:30463242-30463243	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.374T>A; p.V125D; 13:30462635-30462635	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.443C>G; p.A148G; 13:30462566-30462566	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.119_120delAG; p.E40fs*3; 13:30463561-30463562	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.627A>T; p.E209D; 13:30461378-30461378	pleura	pulmonary_blastoma	Substitution - Missense
c.548A>G; p.K183R; 13:30461457-30461457	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.242C>T; p.P81L; 13:30463261-30463261	skin	malignant_melanoma	Substitution - Missense
c.597G>T; p.E199D; 13:30461408-30461408	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.260delA; p.K87fs*65; 13:30463243-30463243	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.466G>A; p.E156K; 13:30462543-30462543	skin	malignant_melanoma	Substitution - Missense
c.588T>G; p.D196E; 13:30461417-30461417	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.488G>A; p.R163Q; 13:30461517-30461517	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.177A>G; p.K59K; 13:30463326-30463326	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.378G>A; p.A126A; 13:30462631-30462631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.378G>A; p.A126A; 13:30462631-30462631	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.378G>A; p.A126A; 13:30462631-30462631	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.253A>G; p.T85A; 13:30463250-30463250	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.71G>A; p.R24Q; 13:30463610-30463610	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.151A>T; p.T51S; 13:30463352-30463352	bone; femur	chondrosarcoma	Substitution - Missense
c.296+1G>A; p.?; 13:30463206-30463206	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.296+1G>A; p.?; 13:30463206-30463206	ovary	carcinoma; serous_carcinoma	Unknown
c.328C>T; p.R110C; 13:30462681-30462681	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.120G>C; p.E40D; 13:30463561-30463561	breast	carcinoma	Substitution - Missense
c.320C>T; p.S107F; 13:30462689-30462689	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.630A>T; p.E210D; 13:30461375-30461375	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.297-3delT; p.?; 13:30462715-30462715	stomach	adenocarcinoma	Unknown
c.630A>T; p.E210D; 13:30461375-30461375	breast	carcinoma	Substitution - Missense
c.584A>G; p.E195G; 13:30461421-30461421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.166G>C; p.E56Q; 13:30463337-30463337	urinary_tract; bladder	carcinoma	Substitution - Missense
c.131A>C; p.K44T; 13:30463550-30463550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.333A>G; p.P111P; 13:30462676-30462676	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.312C>A; p.L104L; 13:30462697-30462697	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.313T>C; p.F105L; 13:30462696-30462696	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense

The somatic mutations from COSMIC database