Entrez Gene

Basic Information
Gene ID	2896
Name	GRN

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.286C>A; p.H96N; 17:44349688-44349688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1340A>C; p.H447P; 17:44352175-44352175	urinary_tract; bladder	carcinoma	Substitution - Missense
c.980C>T; p.T327M; 17:44351596-44351596	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1533C>T; p.S511S; 17:44352460-44352460	skin	malignant_melanoma	Substitution - coding silent
c.709-7C>A; p.?; 17:44351030-44351030	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.578_579CC>TT; p.A193V; 17:44350557-44350558	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.89G>A; p.C30Y; 17:44349253-44349253	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.796G>A; p.A266T; 17:44351124-44351124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.101_102CC>TT; p.P34>?; 17:44349265-44349266	NS	malignant_melanoma	Complex
c.452C>T; p.P151L; 17:44350330-44350330	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1612C>A; p.R538R; 17:44352539-44352539	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.573C>T; p.L191L; 17:44350552-44350552	skin	malignant_melanoma	Substitution - coding silent
c.646C>T; p.P216S; 17:44350738-44350738	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1539C>T; p.H513H; 17:44352466-44352466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.453C>T; p.P151P; 17:44350331-44350331	skin	malignant_melanoma	Substitution - coding silent
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1762G>T; p.A588S; 17:44352778-44352778	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.555delC; p.L187fs*69; 17:44350534-44350534	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.433G>T; p.G145C; 17:44350311-44350311	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.496C>T; p.P166S; 17:44350475-44350475	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.869G>T; p.C290F; 17:44351396-44351396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1110C>T; p.S370S; 17:44351726-44351726	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.545C>T; p.T182M; 17:44350524-44350524	breast	carcinoma	Substitution - Missense
c.128G>A; p.R43H; 17:44349292-44349292	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.674C>A; p.P225H; 17:44350766-44350766	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.585G>T; p.R195S; 17:44350564-44350564	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.350-1G>A; p.?; 17:44350227-44350227	skin	malignant_melanoma	Unknown
c.1639C>T; p.R547C; 17:44352566-44352566	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1426G>C; p.E476Q; 17:44352353-44352353	urinary_tract; bladder	carcinoma	Substitution - Missense
c.388C>T; p.Q130*; 17:44350266-44350266	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.325G>A; p.G109R; 17:44349727-44349727	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.207C>T; p.A69A; 17:44349494-44349494	skin	malignant_melanoma	Substitution - coding silent
c.1578C>T; p.F526F; 17:44352505-44352505	skin	malignant_melanoma	Substitution - coding silent
c.467C>T; p.S156F; 17:44350446-44350446	skin; arm	malignant_melanoma	Substitution - Missense
c.615G>A; p.S205S; 17:44350707-44350707	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.9C>T; p.T3T; 17:44349173-44349173	skin	malignant_melanoma	Substitution - coding silent
c.205G>C; p.A69P; 17:44349492-44349492	skin	malignant_melanoma	Substitution - Missense
c.127C>T; p.R43C; 17:44349291-44349291	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.429C>A; p.V143V; 17:44350307-44350307	breast	carcinoma	Substitution - coding silent
c.332C>T; p.S111F; 17:44349734-44349734	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1617G>A; p.Q539Q; 17:44352544-44352544	skin	malignant_melanoma	Substitution - coding silent
c.1555G>A; p.V519M; 17:44352482-44352482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1027C>T; p.P343S; 17:44351643-44351643	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.340C>G; p.Q114E; 17:44349742-44349742	breast	carcinoma	Substitution - Missense
c.1647C>T; p.G549G; 17:44352663-44352663	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.949G>T; p.D317Y; 17:44351565-44351565	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.77G>T; p.C26F; 17:44349241-44349241	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1174C>A; p.P392T; 17:44351790-44351790	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.914G>A; p.G305D; 17:44351441-44351441	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1496T>G; p.V499G; 17:44352423-44352423	skin	malignant_melanoma	Substitution - Missense
c.1342A>G; p.T448A; 17:44352177-44352177	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1664G>T; p.R555L; 17:44352680-44352680	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.504T>G; p.G168G; 17:44350483-44350483	breast	carcinoma	Substitution - coding silent
c.924T>C; p.P308P; 17:44351451-44351451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1115G>A; p.C372Y; 17:44351731-44351731	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.414G>A; p.T138T; 17:44350292-44350292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.347C>G; p.S116*; 17:44349749-44349749	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1535C>T; p.P512L; 17:44352462-44352462	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.895C>T; p.L299L; 17:44351422-44351422	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.783C>T; p.L261L; 17:44351111-44351111	skin	malignant_melanoma	Substitution - coding silent
c.1590C>A; p.N530K; 17:44352517-44352517	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1704G>C; p.R568S; 17:44352720-44352720	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1624G>A; p.A542T; 17:44352551-44352551	stomach	adenocarcinoma	Substitution - Missense
c.630C>T; p.D210D; 17:44350722-44350722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.630C>T; p.D210D; 17:44350722-44350722	stomach	adenocarcinoma	Substitution - coding silent
c.1721G>A; p.R574H; 17:44352737-44352737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1721G>A; p.R574H; 17:44352737-44352737	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1163G>A; p.C388Y; 17:44351779-44351779	skin	malignant_melanoma	Substitution - Missense
c.1060C>G; p.L354V; 17:44351676-44351676	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1335C>T; p.D445D; 17:44352170-44352170	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1569A>C; p.E523D; 17:44352496-44352496	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.103G>A; p.G35R; 17:44349267-44349267	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.427G>A; p.V143I; 17:44350305-44350305	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.893G>A; p.R298H; 17:44351420-44351420	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1292C>T; p.A431V; 17:44352127-44352127	breast	carcinoma	Substitution - Missense
c.1736G>A; p.R579H; 17:44352752-44352752	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.828G>A; p.A276A; 17:44351156-44351156	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.828G>A; p.A276A; 17:44351156-44351156	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.441G>T; p.W147C; 17:44350319-44350319	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.828G>A; p.A276A; 17:44351156-44351156	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.410C>T; p.S137F; 17:44350288-44350288	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.327G>A; p.G109G; 17:44349729-44349729	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.360C>T; p.S120S; 17:44350238-44350238	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.360C>T; p.S120S; 17:44350238-44350238	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.183C>T; p.C61C; 17:44349470-44349470	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.229G>A; p.V77I; 17:44349516-44349516	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>A; p.V77I; 17:44349516-44349516	ovary	carcinoma; clear_cell_carcinoma	Substitution - Missense
c.67G>T; p.G23C; 17:44349231-44349231	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1148C>T; p.S383F; 17:44351764-44351764	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.503G>A; p.G168D; 17:44350482-44350482	skin	malignant_melanoma	Substitution - Missense
c.1707T>C; p.G569G; 17:44352723-44352723	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1735C>A; p.R579S; 17:44352751-44352751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.136C>G; p.L46V; 17:44349300-44349300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.824C>A; p.P275H; 17:44351152-44351152	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626C>T; p.P209L; 17:44350718-44350718	skin	malignant_melanoma	Substitution - Missense
c.56G>A; p.R19Q; 17:44349220-44349220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1304C>T; p.S435F; 17:44352139-44352139	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.498G>A; p.P166P; 17:44350477-44350477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.494G>A; p.C165Y; 17:44350473-44350473	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.85G>T; p.A29S; 17:44349249-44349249	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.85G>T; p.A29S; 17:44349249-44349249	oesophagus	carcinoma	Substitution - Missense
c.265-3C>T; p.?; 17:44349664-44349664	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1695C>T; p.C565C; 17:44352711-44352711	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.895C>G; p.L299V; 17:44351422-44351422	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1226C>A; p.T409K; 17:44352061-44352061	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1146G>T; p.T382T; 17:44351762-44351762	thyroid	other; neoplasm	Substitution - coding silent
c.1560G>T; p.E520D; 17:44352487-44352487	breast	carcinoma	Substitution - Missense
c.826G>A; p.A276T; 17:44351154-44351154	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database