Entrez Gene

Basic Information
Gene ID	27250
Name	PDCD4

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.187_204del18; p.L63_S68delLRKNSS; 10:110881376-110881393	breast	carcinoma; basal_(triple-negative)_carcinoma	Deletion - In frame
c.929G>A; p.R310H; 10:110890609-110890609	breast	carcinoma	Substitution - Missense
c.1114T>A; p.L372I; 10:110894427-110894427	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.1114T>A; p.L372I; 10:110894427-110894427	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.226T>C; p.S76P; 10:110881415-110881415	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.206G>A; p.R69Q; 10:110881395-110881395	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1323A>G; p.K441K; 10:110896061-110896061	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1237C>T; p.P413S; 10:110895975-110895975	skin	malignant_melanoma	Substitution - Missense
c.62A>G; p.D21G; 10:110881251-110881251	skin	malignant_melanoma	Substitution - Missense
c.1086G>T; p.E362D; 10:110894186-110894186	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1212T>C; p.G404G; 10:110895950-110895950	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.228G>T; p.S76S; 10:110881417-110881417	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.227C>T; p.S76L; 10:110881416-110881416	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.278C>T; p.T93I; 10:110881467-110881467	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1283G>A; p.R428Q; 10:110896021-110896021	pancreas	carcinoma	Substitution - Missense
c.558A>G; p.E186E; 10:110887667-110887667	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1031T>C; p.I344T; 10:110894131-110894131	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.860A>G; p.D287G; 10:110889615-110889615	thyroid	carcinoma	Substitution - Missense
c.154G>A; p.E52K; 10:110881343-110881343	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.111G>T; p.K37N; 10:110881300-110881300	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1220G>T; p.R407I; 10:110895958-110895958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.P141S; 10:110883077-110883077	skin	malignant_melanoma	Substitution - Missense
c.557A>G; p.E186G; 10:110887666-110887666	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.604G>A; p.V202M; 10:110887713-110887713	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1333G>T; p.D445Y; 10:110896071-110896071	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.4G>A; p.D2N; 10:110876031-110876031	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.736G>T; p.D246Y; 10:110887845-110887845	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.736G>T; p.D246Y; 10:110887845-110887845	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.555G>A; p.A185A; 10:110885366-110885366	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.172A>G; p.K58E; 10:110881361-110881361	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.450T>C; p.C150C; 10:110885261-110885261	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1372G>A; p.E458K; 10:110898050-110898050	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.37C>T; p.P13S; 10:110876064-110876064	skin	malignant_melanoma	Substitution - Missense
c.228G>A; p.S76S; 10:110881417-110881417	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1295A>T; p.E432V; 10:110896033-110896033	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1303C>T; p.Q435*; 10:110896041-110896041	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Nonsense
c.44-2A>C; p.?; 10:110881231-110881231	breast	carcinoma	Unknown
c.1009G>T; p.E337*; 10:110894109-110894109	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1274T>A; p.V425E; 10:110896012-110896012	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.342G>C; p.K114N; 10:110881531-110881531	urinary_tract; bladder	carcinoma	Substitution - Missense
c.96G>A; p.G32G; 10:110881285-110881285	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.394G>A; p.D132N; 10:110883050-110883050	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.724A>G; p.K242E; 10:110887833-110887833	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.163_164insT; p.N56fs*1; 10:110881352-110881353	liver	carcinoma	Insertion - Frameshift
c.308G>A; p.R103Q; 10:110881497-110881497	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.337C>T; p.P113S; 10:110881526-110881526	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.498G>T; p.K166N; 10:110885309-110885309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.867G>A; p.V289V; 10:110889622-110889622	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.867G>A; p.V289V; 10:110889622-110889622	skin	malignant_melanoma	Substitution - coding silent
c.358G>C; p.G120R; 10:110883014-110883014	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.169G>A; p.A57T; 10:110881358-110881358	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.249C>T; p.D83D; 10:110881438-110881438	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.426_427delCT; p.N142fs*2; 10:110883082-110883083	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.870G>T; p.Q290H; 10:110889625-110889625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.251C>T; p.A84V; 10:110881440-110881440	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.151A>G; p.N51D; 10:110881340-110881340	skin	malignant_melanoma	Substitution - Missense
c.133A>G; p.I45V; 10:110881322-110881322	urinary_tract; bladder	carcinoma	Substitution - Missense
c.914C>T; p.S305F; 10:110890594-110890594	skin	malignant_melanoma	Substitution - Missense
c.442-1G>A; p.?; 10:110885252-110885252	skin	malignant_melanoma	Unknown
c.77G>A; p.G26D; 10:110881266-110881266	central_nervous_system; brain	glioma	Substitution - Missense
c.533A>G; p.H178R; 10:110885344-110885344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>A; p.P255H; 10:110887873-110887873	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.866T>C; p.V289A; 10:110889621-110889621	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.330G>T; p.R110S; 10:110881519-110881519	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1373A>G; p.E458G; 10:110898051-110898051	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1071T>G; p.P357P; 10:110894171-110894171	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.923G>C; p.G308A; 10:110890603-110890603	breast	carcinoma	Substitution - Missense
c.960G>C; p.G320G; 10:110890640-110890640	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1071T>C; p.P357P; 10:110894171-110894171	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.621A>T; p.L207F; 10:110887730-110887730	lung	carcinoma; adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database