Entrez Gene

Basic Information
Gene ID	27165
Name	GLS2

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.480C>A; p.F160L; 12:56479106-56479106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.538G>A; p.A180T; 12:56478259-56478259	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.969C>T; p.A323A; 12:56475071-56475071	skin	malignant_melanoma	Substitution - coding silent
c.414C>T; p.S138S; 12:56479172-56479172	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1411C>T; p.R471W; 12:56473266-56473266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1411C>T; p.R471W; 12:56473266-56473266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1411C>A; p.R471R; 12:56473266-56473266	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.262C>T; p.P88S; 12:56480308-56480308	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.517G>A; p.E173K; 12:56479069-56479069	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.525T>C; p.T175T; 12:56479061-56479061	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.918C>T; p.F306F; 12:56475635-56475635	oesophagus	carcinoma	Substitution - coding silent
c.1523C>G; p.S508*; 12:56472184-56472184	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1484A>G; p.Y495C; 12:56472717-56472717	pancreas	carcinoma	Substitution - Missense
c.1484A>G; p.Y495C; 12:56472717-56472717	pancreas	carcinoma	Substitution - Missense
c.183-4A>G; p.?; 12:56480391-56480391	ovary	other; neoplasm	Unknown
c.89C>T; p.P30L; 12:56488030-56488030	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1649A>G; p.D550G; 12:56471776-56471776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1412G>A; p.R471Q; 12:56473265-56473265	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.615-1_617delGGCA; p.?; 12:56478094-56478097	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1123A>G; p.I375V; 12:56474645-56474645	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1102G>A; p.A368T; 12:56474666-56474666	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.584G>A; p.G195D; 12:56478213-56478213	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1669C>T; p.L557L; 12:56471627-56471627	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1454A>C; p.K485T; 12:56472747-56472747	liver	carcinoma	Substitution - Missense
c.212G>A; p.R71H; 12:56480358-56480358	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.319C>T; p.R107W; 12:56479865-56479865	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.319C>T; p.R107W; 12:56479865-56479865	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1586A>C; p.E529A; 12:56472121-56472121	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1646delA; p.K549fs*50; 12:56471779-56471779	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.487C>G; p.H163D; 12:56479099-56479099	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.654G>A; p.Q218Q; 12:56478057-56478057	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.673A>C; p.T225P; 12:56478038-56478038	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1101C>T; p.L367L; 12:56474667-56474667	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1101C>T; p.L367L; 12:56474667-56474667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1558C>T; p.R520C; 12:56472149-56472149	pancreas	carcinoma	Substitution - Missense
c.1558C>T; p.R520C; 12:56472149-56472149	pancreas	carcinoma	Substitution - Missense
c.1447C>T; p.R483W; 12:56473230-56473230	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1558C>T; p.R520C; 12:56472149-56472149	pancreas	carcinoma	Substitution - Missense
c.1559G>A; p.R520H; 12:56472148-56472148	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1177A>G; p.M393V; 12:56474591-56474591	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.422T>C; p.I141T; 12:56479164-56479164	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1650C>A; p.D550E; 12:56471775-56471775	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1786G>A; p.E596K; 12:56471510-56471510	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.954G>A; p.G318G; 12:56475086-56475086	skin	malignant_melanoma	Substitution - coding silent
c.1614G>A; p.L538L; 12:56471811-56471811	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1475T>A; p.F492Y; 12:56472726-56472726	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1032T>C; p.L344L; 12:56474861-56474861	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1339_1340GG>AA; p.G447K; 12:56473479-56473480	skin	malignant_melanoma	Substitution - Missense
c.1648G>T; p.D550Y; 12:56471777-56471777	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1771G>A; p.E591K; 12:56471525-56471525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.987G>A; p.K329K; 12:56475053-56475053	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1117T>C; p.C373R; 12:56474651-56474651	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117T>C; p.C373R; 12:56474651-56474651	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.930-1G>A; p.?; 12:56475111-56475111	skin	malignant_melanoma	Unknown
c.325C>T; p.R109*; 12:56479859-56479859	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Nonsense
c.1536G>A; p.M512I; 12:56472171-56472171	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.256C>T; p.R86*; 12:56480314-56480314	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1703T>G; p.V568G; 12:56471593-56471593	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.257G>A; p.R86Q; 12:56480313-56480313	skin	malignant_melanoma	Substitution - Missense
c.257G>A; p.R86Q; 12:56480313-56480313	skin; neck	malignant_melanoma	Substitution - Missense
c.1491C>T; p.G497G; 12:56472710-56472710	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1647delG; p.D550fs*49; 12:56471778-56471778	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1325G>A; p.G442E; 12:56473494-56473494	stomach	adenocarcinoma	Substitution - Missense
c.1501G>T; p.A501S; 12:56472700-56472700	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.58C>G; p.R20G; 12:56488061-56488061	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1795G>T; p.E599*; 12:56471501-56471501	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.394C>A; p.L132I; 12:56479790-56479790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.186T>C; p.D62D; 12:56480384-56480384	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.276C>A; p.F92L; 12:56480294-56480294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.984C>G; p.L328L; 12:56475056-56475056	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.865G>C; p.D289H; 12:56475950-56475950	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1189G>A; p.G397S; 12:56474579-56474579	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.94C>A; p.L32I; 12:56488025-56488025	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1727A>T; p.Q576L; 12:56471569-56471569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326G>A; p.R109Q; 12:56479858-56479858	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.946G>A; p.E316K; 12:56475094-56475094	skin	malignant_melanoma	Substitution - Missense
c.1326G>A; p.G442G; 12:56473493-56473493	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1326G>A; p.G442G; 12:56473493-56473493	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.228C>A; p.L76L; 12:56480342-56480342	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.388C>A; p.R130R; 12:56479796-56479796	central_nervous_system; medulla	primitive_neuroectodermal_tumour-medulloblastoma; classic	Substitution - coding silent
c.58C>T; p.R20*; 12:56488061-56488061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1127C>T; p.T376I; 12:56474641-56474641	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.748C>T; p.R250C; 12:56477963-56477963	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.Q102*; 12:56479880-56479880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1494T>C; p.D498D; 12:56472707-56472707	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494T>C; p.D498D; 12:56472707-56472707	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494T>C; p.D498D; 12:56472707-56472707	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1617C>T; p.I539I; 12:56471808-56471808	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1617C>T; p.I539I; 12:56471808-56471808	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180C>T; p.H394Y; 12:56474588-56474588	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1016A>G; p.D339G; 12:56474877-56474877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1053T>C; p.C351C; 12:56474715-56474715	bone; femur	chondrosarcoma	Substitution - coding silent
c.1430G>A; p.R477H; 12:56473247-56473247	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1287G>A; p.M429I; 12:56473532-56473532	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1310_1311insC; p.L438fs*9; 12:56473508-56473509	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift

The somatic mutations from COSMIC database