Entrez Gene

Basic Information
Gene ID	2303
Name	FOXC2

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.382G>A; p.E128K; 16:86567717-86567717	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.354C>T; p.N118N; 16:86567689-86567689	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.706G>T; p.A236S; 16:86568041-86568041	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1477C>T; p.P493S; 16:86568812-86568812	skin	malignant_melanoma	Substitution - Missense
c.70T>C; p.Y24H; 16:86567405-86567405	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.453C>A; p.D151E; 16:86567788-86567788	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.117C>T; p.G39G; 16:86567452-86567452	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.748G>A; p.G250S; 16:86568083-86568083	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.459C>G; p.Y153*; 16:86567794-86567794	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.420C>T; p.P140P; 16:86567755-86567755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.306C>T; p.I102I; 16:86567641-86567641	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.441C>G; p.T147T; 16:86567776-86567776	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.152G>A; p.G51E; 16:86567487-86567487	lung	carcinoid-endocrine_tumour; typical	Substitution - Missense
c.420C>A; p.P140P; 16:86567755-86567755	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.409G>A; p.D137N; 16:86567744-86567744	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.409G>A; p.D137N; 16:86567744-86567744	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.563C>T; p.P188L; 16:86567898-86567898	urinary_tract; bladder	carcinoma	Substitution - Missense
c.456C>G; p.S152S; 16:86567791-86567791	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1000C>T; p.R334*; 16:86568335-86568335	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1371C>T; p.H457H; 16:86568706-86568706	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.868G>A; p.G290R; 16:86568203-86568203	liver	carcinoma	Substitution - Missense
c.868G>A; p.G290R; 16:86568203-86568203	liver	carcinoma	Substitution - Missense
c.190C>T; p.P64S; 16:86567525-86567525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.405C>T; p.R135R; 16:86567740-86567740	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1259A>G; p.Q420R; 16:86568594-86568594	liver	carcinoma	Substitution - Missense
c.1078G>C; p.D360H; 16:86568413-86568413	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1259A>G; p.Q420R; 16:86568594-86568594	liver	carcinoma	Substitution - Missense
c.1354G>A; p.E452K; 16:86568689-86568689	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1486T>C; p.Y496H; 16:86568821-86568821	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.456C>A; p.S152S; 16:86567791-86567791	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.616G>C; p.E206Q; 16:86567951-86567951	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.261C>A; p.N87K; 16:86567596-86567596	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.324C>G; p.F108L; 16:86567659-86567659	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.60C>T; p.S20S; 16:86567395-86567395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.516C>T; p.D172D; 16:86567851-86567851	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.872C>G; p.A291G; 16:86568207-86568207	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.662C>T; p.A221V; 16:86567997-86567997	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1243G>A; p.G415R; 16:86568578-86568578	skin	malignant_melanoma	Substitution - Missense
c.83C>A; p.A28E; 16:86567418-86567418	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.954T>C; p.A318A; 16:86568289-86568289	liver	carcinoma	Substitution - coding silent
c.1094C>T; p.P365L; 16:86568429-86568429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.121T>C; p.Y41H; 16:86567456-86567456	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1280A>G; p.N427S; 16:86568615-86568615	skin; mucosal	malignant_melanoma	Substitution - Missense
c.484C>T; p.L162L; 16:86567819-86567819	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.128G>A; p.G43D; 16:86567463-86567463	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.157G>A; p.G53S; 16:86567492-86567492	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1427G>T; p.S476I; 16:86568762-86568762	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.35C>A; p.A12D; 16:86567370-86567370	urinary_tract; bladder	carcinoma	Substitution - Missense
c.35C>A; p.A12D; 16:86567370-86567370	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.562C>T; p.P188S; 16:86567897-86567897	skin	malignant_melanoma	Substitution - Missense
c.1456C>A; p.P486T; 16:86568791-86568791	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.118G>A; p.V40I; 16:86567453-86567453	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1468C>T; p.H490Y; 16:86568803-86568803	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1026C>T; p.A342A; 16:86568361-86568361	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.531G>T; p.K177N; 16:86567866-86567866	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.490C>T; p.R164C; 16:86567825-86567825	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1454C>A; p.P485Q; 16:86568789-86568789	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1454C>A; p.P485Q; 16:86568789-86568789	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1440C>T; p.P480P; 16:86568775-86568775	skin	malignant_melanoma	Substitution - coding silent
c.360C>G; p.I120M; 16:86567695-86567695	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1347C>T; p.N449N; 16:86568682-86568682	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1439C>G; p.P480R; 16:86568774-86568774	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.197C>T; p.A66V; 16:86567532-86567532	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.84G>A; p.A28A; 16:86567419-86567419	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.69T>G; p.N23K; 16:86567404-86567404	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.646G>A; p.E216K; 16:86567981-86567981	skin	malignant_melanoma	Substitution - Missense
c.8C>T; p.A3V; 16:86567343-86567343	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.186C>G; p.H62Q; 16:86567521-86567521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.608C>A; p.A203D; 16:86567943-86567943	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.589_590insC; p.H199fs*264; 16:86567924-86567925	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1251C>G; p.A417A; 16:86568586-86568586	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.192C>T; p.P64P; 16:86567527-86567527	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.364C>A; p.H122N; 16:86567699-86567699	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.282C>T; p.T94T; 16:86567617-86567617	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.826A>G; p.M276V; 16:86568161-86568161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.590C>A; p.T197N; 16:86567925-86567925	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.363_364CC>AA; p.H122N; 16:86567698-86567699	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.363_364CC>AA; p.H122N; 16:86567698-86567699	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1497G>A; p.T499T; 16:86568832-86568832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1497G>A; p.T499T; 16:86568832-86568832	skin	malignant_melanoma	Substitution - coding silent
c.320C>A; p.P107H; 16:86567655-86567655	ovary	carcinoma; serous_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database