Entrez Gene

Basic Information
Gene ID	222663
Name	SCUBE3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.149C>T; p.P50L; 6:35227643-35227643	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2292C>T; p.R764R; 6:35244702-35244702	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2292C>T; p.R764R; 6:35244702-35244702	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2292C>T; p.R764R; 6:35244702-35244702	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2973C>A; p.P991P; 6:35248696-35248696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2519G>A; p.R840H; 6:35245345-35245345	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2931C>A; p.F977L; 6:35248654-35248654	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2519G>A; p.R840H; 6:35245345-35245345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.460C>A; p.R154R; 6:35231850-35231850	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1260C>A; p.G420G; 6:35241607-35241607	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2290C>T; p.R764C; 6:35244700-35244700	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1002C>G; p.N334K; 6:35240423-35240423	central_nervous_system; brain	glioma	Substitution - Missense
c.2128C>A; p.P710T; 6:35244019-35244019	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1309C>T; p.P437S; 6:35241656-35241656	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2718C>T; p.A906A; 6:35246062-35246062	breast	carcinoma	Substitution - coding silent
c.829G>T; p.D277Y; 6:35238018-35238018	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.252T>C; p.H84H; 6:35228657-35228657	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.928C>A; p.L310I; 6:35239850-35239850	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.672T>A; p.H224Q; 6:35233261-35233261	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1610G>A; p.R537Q; 6:35242697-35242697	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.H102Y; 6:35228709-35228709	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.110C>T; p.T37I; 6:35227604-35227604	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1256C>T; p.S419F; 6:35241603-35241603	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1256C>T; p.S419F; 6:35241603-35241603	skin	malignant_melanoma	Substitution - Missense
c.2844C>A; p.L948L; 6:35248567-35248567	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1119C>G; p.I373M; 6:35241190-35241190	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1389G>A; p.G463G; 6:35241882-35241882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2786G>A; p.R929Q; 6:35246239-35246239	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.877C>A; p.R293S; 6:35239799-35239799	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2476G>A; p.A826T; 6:35245302-35245302	skin	malignant_melanoma	Substitution - Missense
c.2127C>T; p.C709C; 6:35244018-35244018	thyroid	other; neoplasm	Substitution - coding silent
c.226C>T; p.R76*; 6:35228631-35228631	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.664G>A; p.G222S; 6:35233253-35233253	liver	carcinoma	Substitution - Missense
c.1595G>A; p.R532Q; 6:35242682-35242682	skin	malignant_melanoma	Substitution - Missense
c.1595G>A; p.R532Q; 6:35242682-35242682	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.664G>A; p.G222S; 6:35233253-35233253	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.511A>G; p.I171V; 6:35232891-35232891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.664G>A; p.G222S; 6:35233253-35233253	liver	carcinoma	Substitution - Missense
c.845G>A; p.R282H; 6:35239767-35239767	liver	carcinoma	Substitution - Missense
c.845G>A; p.R282H; 6:35239767-35239767	liver	carcinoma	Substitution - Missense
c.2647C>T; p.R883C; 6:35245991-35245991	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2532C>T; p.I844I; 6:35245358-35245358	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2880G>T; p.Q960H; 6:35248603-35248603	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.838G>A; p.E280K; 6:35239760-35239760	skin	malignant_melanoma	Substitution - Missense
c.632C>T; p.T211M; 6:35233221-35233221	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.835G>C; p.D279H; 6:35239757-35239757	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1446G>A; p.R482R; 6:35242232-35242232	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2462C>T; p.P821L; 6:35245288-35245288	prostate	adenoma	Substitution - Missense
c.1810G>A; p.D604N; 6:35243137-35243137	skin	malignant_melanoma	Substitution - Missense
c.2117G>A; p.C706Y; 6:35244008-35244008	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.2372A>C; p.D791A; 6:35244782-35244782	liver	carcinoma	Substitution - Missense
c.732C>T; p.N244N; 6:35237921-35237921	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2008G>A; p.D670N; 6:35243692-35243692	skin	malignant_melanoma	Substitution - Missense
c.1740G>C; p.L580L; 6:35243067-35243067	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1486C>T; p.L496L; 6:35242272-35242272	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.137G>A; p.C46Y; 6:35227631-35227631	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.821C>T; p.T274M; 6:35238010-35238010	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.877C>T; p.R293C; 6:35239799-35239799	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2968A>G; p.R990G; 6:35248691-35248691	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.746G>A; p.S249N; 6:35237935-35237935	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1064G>A; p.C355Y; 6:35240485-35240485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1678G>A; p.A560T; 6:35242765-35242765	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1852C>T; p.R618*; 6:35243179-35243179	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1681G>A; p.E561K; 6:35242768-35242768	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1681G>A; p.E561K; 6:35242768-35242768	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2583C>T; p.L861L; 6:35245409-35245409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2838G>T; p.K946N; 6:35248561-35248561	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1251C>G; p.N417K; 6:35241598-35241598	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2058C>T; p.V686V; 6:35243742-35243742	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2463G>A; p.P821P; 6:35245289-35245289	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1534G>T; p.G512C; 6:35242320-35242320	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.865G>T; p.D289Y; 6:35239787-35239787	prostate	carcinoma	Substitution - Missense
c.2282G>A; p.R761H; 6:35244692-35244692	pancreas	carcinoma	Substitution - Missense
c.2533G>A; p.V845M; 6:35245359-35245359	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2361C>T; p.S787S; 6:35244771-35244771	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1759C>G; p.L587V; 6:35243086-35243086	skin	malignant_melanoma	Substitution - Missense
c.2160G>C; p.R720R; 6:35244051-35244051	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1849G>A; p.E617K; 6:35243176-35243176	skin	malignant_melanoma	Substitution - Missense
c.1849G>A; p.E617K; 6:35243176-35243176	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2026G>A; p.D676N; 6:35243710-35243710	skin	malignant_melanoma	Substitution - Missense
c.416G>A; p.R139Q; 6:35231806-35231806	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1331C>A; p.T444K; 6:35241824-35241824	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.416G>A; p.R139Q; 6:35231806-35231806	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.416G>A; p.R139Q; 6:35231806-35231806	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2909A>G; p.K970R; 6:35248632-35248632	thyroid	other; neoplasm	Substitution - Missense
c.2126G>C; p.C709S; 6:35244017-35244017	thyroid	other; neoplasm	Substitution - Missense
c.318C>T; p.D106D; 6:35228723-35228723	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2302G>A; p.G768S; 6:35244712-35244712	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.663C>T; p.C221C; 6:35233252-35233252	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1473A>G; p.K491K; 6:35242259-35242259	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1755G>A; p.K585K; 6:35243082-35243082	skin	malignant_melanoma	Substitution - coding silent
c.1156G>A; p.G386S; 6:35241227-35241227	breast	carcinoma	Substitution - Missense
c.1928C>T; p.T643M; 6:35243612-35243612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2817C>A; p.H939Q; 6:35246270-35246270	parathyroid	adenoma	Substitution - Missense
c.668G>T; p.C223F; 6:35233257-35233257	oesophagus	carcinoma	Substitution - Missense
c.717C>A; p.T239T; 6:35237906-35237906	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1301G>T; p.R434L; 6:35241648-35241648	large_intestine; colon	adenoma	Substitution - Missense
c.1693+2T>C; p.?; 6:35242782-35242782	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.1138C>A; p.Q380K; 6:35241209-35241209	prostate	adenoma	Substitution - Missense
c.844C>T; p.R282C; 6:35239766-35239766	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2106G>A; p.G702G; 6:35243997-35243997	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2694C>A; p.F898L; 6:35246038-35246038	breast	carcinoma	Substitution - Missense
c.2405G>C; p.R802P; 6:35245231-35245231	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1418-1G>A; p.?; 6:35242203-35242203	skin; mucosal	malignant_melanoma	Unknown
c.1863G>A; p.P621P; 6:35243190-35243190	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1654C>T; p.L552L; 6:35242741-35242741	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2455A>T; p.N819Y; 6:35245281-35245281	skin	malignant_melanoma	Substitution - Missense
c.1385A>G; p.N462S; 6:35241878-35241878	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2856C>A; p.F952L; 6:35248579-35248579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1168C>T; p.L390L; 6:35241239-35241239	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2907C>A; p.H969Q; 6:35248630-35248630	thyroid	other; neoplasm	Substitution - Missense
c.988C>T; p.H330Y; 6:35240409-35240409	skin	malignant_melanoma	Substitution - Missense
c.361G>T; p.G121C; 6:35231751-35231751	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2558C>A; p.S853Y; 6:35245384-35245384	urinary_tract; bladder	carcinoma	Substitution - Missense
c.897C>T; p.F299F; 6:35239819-35239819	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.897C>T; p.F299F; 6:35239819-35239819	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.897C>T; p.F299F; 6:35239819-35239819	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1882G>A; p.G628R; 6:35243209-35243209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1770C>T; p.S590S; 6:35243097-35243097	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2517G>A; p.K839K; 6:35245343-35245343	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1475G>A; p.C492Y; 6:35242261-35242261	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1988G>C; p.R663T; 6:35243672-35243672	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.871A>G; p.I291V; 6:35239793-35239793	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1033C>T; p.R345C; 6:35240454-35240454	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2119C>G; p.Q707E; 6:35244010-35244010	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.234T>C; p.D78D; 6:35228639-35228639	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1707G>T; p.L569L; 6:35243034-35243034	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1417G>A; p.E473K; 6:35241910-35241910	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.522G>A; p.E174E; 6:35232902-35232902	breast	carcinoma	Substitution - coding silent
c.867C>A; p.D289E; 6:35239789-35239789	breast	carcinoma	Substitution - Missense
c.1312+1G>T; p.?; 6:35241660-35241660	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2132G>A; p.R711H; 6:35244023-35244023	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2628G>C; p.E876D; 6:35245972-35245972	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2323C>T; p.R775C; 6:35244733-35244733	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2518C>T; p.R840C; 6:35245344-35245344	urinary_tract; bladder	carcinoma	Substitution - Missense
c.729C>A; p.N243K; 6:35237918-35237918	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.533G>A; p.G178E; 6:35232913-35232913	skin	malignant_melanoma	Substitution - Missense
c.2007C>A; p.C669*; 6:35243691-35243691	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2523G>T; p.K841N; 6:35245349-35245349	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1216A>C; p.S406R; 6:35241563-35241563	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2349A>G; p.P783P; 6:35244759-35244759	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.499G>A; p.G167S; 6:35232879-35232879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.499G>A; p.G167S; 6:35232879-35232879	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2912A>T; p.E971V; 6:35248635-35248635	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2912A>T; p.E971V; 6:35248635-35248635	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1940G>A; p.G647D; 6:35243624-35243624	skin	malignant_melanoma	Substitution - Missense
c.1940G>A; p.G647D; 6:35243624-35243624	skin	malignant_melanoma	Substitution - Missense
c.1940G>A; p.G647D; 6:35243624-35243624	skin	malignant_melanoma	Substitution - Missense
c.1619G>A; p.R540Q; 6:35242706-35242706	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.441C>G; p.N147K; 6:35231831-35231831	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.961G>A; p.E321K; 6:35240382-35240382	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.539T>C; p.I180T; 6:35232919-35232919	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2542G>T; p.E848*; 6:35245368-35245368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1417+2T>A; p.?; 6:35241912-35241912	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Unknown
c.731A>C; p.N244T; 6:35237920-35237920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2400G>A; p.K800K; 6:35244810-35244810	skin	malignant_melanoma	Substitution - coding silent
c.303C>A; p.F101L; 6:35228708-35228708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.878G>A; p.R293H; 6:35239800-35239800	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.693C>T; p.T231T; 6:35233282-35233282	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.773T>C; p.V258A; 6:35237962-35237962	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2785C>T; p.R929*; 6:35246238-35246238	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2889C>T; p.F963F; 6:35248612-35248612	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1138C>T; p.Q380*; 6:35241209-35241209	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1332G>A; p.T444T; 6:35241825-35241825	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2804C>A; p.A935D; 6:35246257-35246257	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2234C>A; p.T745N; 6:35244125-35244125	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1242C>G; p.L414L; 6:35241589-35241589	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1432delT; p.S478fs*103; 6:35242218-35242218	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.2105G>A; p.G702E; 6:35243996-35243996	skin	malignant_melanoma	Substitution - Missense
c.2180G>A; p.G727D; 6:35244071-35244071	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.913A>C; p.K305Q; 6:35239835-35239835	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2328G>A; p.Q776Q; 6:35244738-35244738	skin	malignant_melanoma	Substitution - coding silent
c.1510G>A; p.E504K; 6:35242296-35242296	skin	malignant_melanoma	Substitution - Missense

The somatic mutations from COSMIC database