Entrez Gene

Basic Information
Gene ID	185
Name	AGTR1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.983C>T; p.S328L; 3:148742018-148742018	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.974A>G; p.K325R; 3:148742009-148742009	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.306G>T; p.K102N; 3:148741341-148741341	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.409C>T; p.R137C; 3:148741444-148741444	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.306G>T; p.K102N; 3:148741341-148741341	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.A163T; 3:148741522-148741522	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.A163T; 3:148741522-148741522	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.850A>G; p.M284V; 3:148741885-148741885	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.552T>C; p.Y184Y; 3:148741587-148741587	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.232T>G; p.L78V; 3:148741267-148741267	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.415C>T; p.R139*; 3:148741450-148741450	skin	malignant_melanoma	Substitution - Nonsense
c.415C>T; p.R139*; 3:148741450-148741450	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.667A>G; p.K223E; 3:148741702-148741702	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.240T>G; p.T80T; 3:148741275-148741275	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.920A>C; p.K307T; 3:148741955-148741955	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.963_964CC>TT; p.P322S; 3:148741998-148741999	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.607G>A; p.G203S; 3:148741642-148741642	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.586G>T; p.G196C; 3:148741621-148741621	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.728T>C; p.M243T; 3:148741763-148741763	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.784C>A; p.L262M; 3:148741819-148741819	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.590T>G; p.L197R; 3:148741625-148741625	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.873T>G; p.A291A; 3:148741908-148741908	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.349T>C; p.F117L; 3:148741384-148741384	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.873T>G; p.A291A; 3:148741908-148741908	liver	carcinoma	Substitution - coding silent
c.647C>T; p.T216I; 3:148741682-148741682	skin	malignant_melanoma	Substitution - Missense
c.709G>A; p.D237N; 3:148741744-148741744	skin	malignant_melanoma	Substitution - Missense
c.212C>A; p.A71E; 3:148741247-148741247	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.R167Q; 3:148741535-148741535	skin; trunk	malignant_melanoma	Substitution - Missense
c.500G>A; p.R167Q; 3:148741535-148741535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.613C>A; p.L205M; 3:148741648-148741648	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.R167Q; 3:148741535-148741535	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.500G>A; p.R167Q; 3:148741535-148741535	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.740T>C; p.L247P; 3:148741775-148741775	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.R167Q; 3:148741535-148741535	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.133G>A; p.G45R; 3:148741168-148741168	skin	malignant_melanoma	Substitution - Missense
c.753T>A; p.F251L; 3:148741788-148741788	skin	malignant_melanoma	Substitution - Missense
c.713delT; p.F239fs*3; 3:148741748-148741748	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.923A>C; p.K308T; 3:148741958-148741958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.923A>C; p.K308T; 3:148741958-148741958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.923A>C; p.K308T; 3:148741958-148741958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.569C>A; p.T190N; 3:148741604-148741604	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.252G>T; p.W84C; 3:148741287-148741287	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.750C>G; p.F250L; 3:148741785-148741785	breast	carcinoma	Substitution - Missense
c.702A>G; p.R234R; 3:148741737-148741737	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.778A>G; p.T260A; 3:148741813-148741813	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1007_1008CG>TT; p.T336>?; 3:148742042-148742043	lung	carcinoma; small_cell_carcinoma	Complex
c.171G>A; p.M57I; 3:148741206-148741206	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.513C>G; p.F171L; 3:148741548-148741548	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.814C>T; p.R272C; 3:148741849-148741849	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.535G>T; p.V179F; 3:148741570-148741570	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.42C>A; p.I14I; 3:148741077-148741077	pancreas	carcinoma	Substitution - coding silent
c.109A>G; p.I37V; 3:148741144-148741144	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.62C>T; p.A21V; 3:148741097-148741097	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.570C>T; p.T190T; 3:148741605-148741605	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.377G>A; p.R126Q; 3:148741412-148741412	breast	carcinoma	Substitution - Missense
c.377G>A; p.R126Q; 3:148741412-148741412	skin	malignant_melanoma	Substitution - Missense
c.377G>A; p.R126Q; 3:148741412-148741412	skin	malignant_melanoma	Substitution - Missense
c.634C>A; p.L212I; 3:148741669-148741669	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.46G>C; p.D16H; 3:148741081-148741081	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.829G>A; p.A277T; 3:148741864-148741864	skin	malignant_melanoma	Substitution - Missense
c.74A>C; p.N25T; 3:148741109-148741109	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1017C>A; p.Y339*; 3:148742052-148742052	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.587G>T; p.G196V; 3:148741622-148741622	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.385G>T; p.A129S; 3:148741420-148741420	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.418C>T; p.R140C; 3:148741453-148741453	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.418C>T; p.R140C; 3:148741453-148741453	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.418C>T; p.R140C; 3:148741453-148741453	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1002G>A; p.M334I; 3:148742037-148742037	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.988C>T; p.L330F; 3:148742023-148742023	skin	malignant_melanoma	Substitution - Missense
c.422C>A; p.T141K; 3:148741457-148741457	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.943C>T; p.Q315*; 3:148741978-148741978	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.739C>T; p.L247F; 3:148741774-148741774	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.938T>G; p.F313C; 3:148741973-148741973	skin	malignant_melanoma	Substitution - Missense
c.739C>A; p.L247I; 3:148741774-148741774	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.916G>T; p.G306W; 3:148741951-148741951	breast	carcinoma	Substitution - Missense
c.111C>A; p.I37I; 3:148741146-148741146	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.918G>A; p.G306G; 3:148741953-148741953	skin	malignant_melanoma	Substitution - coding silent
c.918G>A; p.G306G; 3:148741953-148741953	skin	malignant_melanoma	Substitution - coding silent
c.211G>A; p.A71T; 3:148741246-148741246	liver	carcinoma	Substitution - Missense
c.302G>A; p.C101Y; 3:148741337-148741337	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.674C>G; p.A225G; 3:148741709-148741709	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.932G>T; p.R311I; 3:148741967-148741967	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.673G>A; p.A225T; 3:148741708-148741708	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.868A>C; p.I290L; 3:148741903-148741903	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>A; p.G194R; 3:148741615-148741615	skin	malignant_melanoma	Substitution - Missense
c.847G>A; p.A283T; 3:148741882-148741882	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.604C>A; p.L202M; 3:148741639-148741639	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.750C>T; p.F250F; 3:148741785-148741785	skin	malignant_melanoma	Substitution - coding silent
c.701G>T; p.R234I; 3:148741736-148741736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.595delA; p.N200fs*10; 3:148741630-148741630	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.567A>G; p.S189S; 3:148741602-148741602	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.633T>G; p.I211M; 3:148741668-148741668	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.738G>A; p.V246V; 3:148741773-148741773	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.738G>A; p.V246V; 3:148741773-148741773	liver	carcinoma	Substitution - coding silent
c.1062A>G; p.P354P; 3:148742097-148742097	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.419G>A; p.R140H; 3:148741454-148741454	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.719A>C; p.K240T; 3:148741754-148741754	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.394C>A; p.H132N; 3:148741429-148741429	lung	carcinoma	Substitution - Missense
c.971C>T; p.A324V; 3:148742006-148742006	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.495C>G; p.I165M; 3:148741530-148741530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.513C>T; p.F171F; 3:148741548-148741548	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.380A>G; p.Y127C; 3:148741415-148741415	breast	carcinoma	Substitution - Missense
c.134G>C; p.G45A; 3:148741169-148741169	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.573C>T; p.L191L; 3:148741608-148741608	thyroid	other; neoplasm	Substitution - coding silent
c.394C>T; p.H132Y; 3:148741429-148741429	skin	malignant_melanoma	Substitution - Missense
c.575C>A; p.P192Q; 3:148741610-148741610	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.476C>T; p.A159V; 3:148741511-148741511	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.576G>A; p.P192P; 3:148741611-148741611	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.140G>A; p.S47N; 3:148741175-148741175	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.576G>A; p.P192P; 3:148741611-148741611	skin	malignant_melanoma	Substitution - coding silent
c.766C>A; p.H256N; 3:148741801-148741801	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.657G>T; p.W219C; 3:148741692-148741692	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.125G>A; p.G42E; 3:148741160-148741160	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.359C>A; p.T120K; 3:148741394-148741394	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.899T>C; p.L300P; 3:148741934-148741934	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.899T>C; p.L300P; 3:148741934-148741934	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1027G>T; p.D343Y; 3:148742062-148742062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.322G>A; p.V108I; 3:148741357-148741357	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1038C>T; p.S346S; 3:148742073-148742073	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1018C>T; p.R340C; 3:148742053-148742053	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.23A>G; p.E8G; 3:148741058-148741058	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.439G>T; p.V147F; 3:148741474-148741474	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.496C>T; p.H166Y; 3:148741531-148741531	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database