Entrez Gene

Basic Information
Gene ID	1748
Name	DLX4

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.148C>T; p.P50S; 17:49969616-49969616	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.343delA; p.K116fs*17; 17:49973132-49973132	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.554G>A; p.G185E; 17:49973774-49973774	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.577T>C; p.S193P; 17:49973797-49973797	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.577T>C; p.S193P; 17:49973797-49973797	urinary_tract; bladder	carcinoma	Substitution - Missense
c.319G>T; p.E107*; 17:49973108-49973108	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.717G>T; p.M239I; 17:49973937-49973937	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>C; p.A112P; 17:49973123-49973123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.178A>C; p.T60P; 17:49969646-49969646	urinary_tract; bladder	carcinoma	Substitution - Missense
c.535A>G; p.N179D; 17:49973755-49973755	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.92A>C; p.Y31S; 17:49969560-49969560	urinary_tract; bladder	carcinoma	Substitution - Missense
c.350T>C; p.L117P; 17:49973139-49973139	thyroid	other; neoplasm	Substitution - Missense
c.360G>C; p.P120P; 17:49973149-49973149	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.204C>T; p.S68S; 17:49969672-49969672	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.350T>C; p.L117P; 17:49973139-49973139	breast	carcinoma	Substitution - Missense
c.505C>T; p.R169C; 17:49973725-49973725	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.707C>T; p.S236L; 17:49973927-49973927	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.707C>T; p.S236L; 17:49973927-49973927	central_nervous_system; brain	glioma	Substitution - Missense
c.318C>T; p.S106S; 17:49973107-49973107	skin	malignant_melanoma	Substitution - coding silent
c.246C>G; p.L82L; 17:49969714-49969714	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.150G>A; p.P50P; 17:49969618-49969618	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.312A>C; p.E104D; 17:49973101-49973101	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.312A>C; p.E104D; 17:49973101-49973101	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.312A>C; p.E104D; 17:49973101-49973101	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.312A>C; p.E104D; 17:49973101-49973101	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.312A>C; p.E104D; 17:49973101-49973101	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.312A>C; p.E104D; 17:49973101-49973101	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.462C>T; p.L154L; 17:49973251-49973251	liver	carcinoma	Substitution - coding silent
c.462C>T; p.L154L; 17:49973251-49973251	liver	carcinoma	Substitution - coding silent
c.359C>T; p.P120L; 17:49973148-49973148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.359C>T; p.P120L; 17:49973148-49973148	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.144C>T; p.S48S; 17:49969612-49969612	skin	malignant_melanoma	Substitution - coding silent
c.197G>A; p.G66E; 17:49969665-49969665	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.277G>A; p.E93K; 17:49969745-49969745	urinary_tract; bladder	carcinoma	Substitution - Missense
c.660C>G; p.N220K; 17:49973880-49973880	liver	carcinoma	Substitution - Missense
c.660C>G; p.N220K; 17:49973880-49973880	liver	carcinoma	Substitution - Missense
c.563C>T; p.P188L; 17:49973783-49973783	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.547C>T; p.Q183*; 17:49973767-49973767	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.547C>T; p.Q183*; 17:49973767-49973767	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.348G>T; p.K116N; 17:49973137-49973137	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.513G>A; p.K171K; 17:49973733-49973733	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.676T>C; p.Y226H; 17:49973896-49973896	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.335delC; p.A114fs*19; 17:49973124-49973124	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.605C>T; p.P202L; 17:49973825-49973825	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>T; p.F187F; 17:49973781-49973781	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.416C>A; p.T139K; 17:49973205-49973205	liver	carcinoma	Substitution - Missense
c.416C>A; p.T139K; 17:49973205-49973205	liver	carcinoma	Substitution - Missense
c.566G>A; p.G189E; 17:49973786-49973786	skin	malignant_melanoma	Substitution - Missense
c.8C>A; p.S3Y; 17:49969476-49969476	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.670G>A; p.A224T; 17:49973890-49973890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.15C>T; p.P5P; 17:49969483-49969483	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.325C>T; p.R109C; 17:49973114-49973114	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.539C>A; p.S180Y; 17:49973759-49973759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.156C>T; p.G52G; 17:49969624-49969624	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.609C>T; p.S203S; 17:49973829-49973829	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

The somatic mutations from COSMIC database