Entrez Gene

Basic Information
Gene ID	10628
Name	TXNIP

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.529C>T; p.R177W; 1:145994974-145994974	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.73G>T; p.E25*; 1:145996194-145996194	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.129C>T; p.A43A; 1:145996138-145996138	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.39C>A; p.V13V; 1:145996228-145996228	breast	carcinoma	Substitution - coding silent
c.1110C>A; p.F370L; 1:145994046-145994046	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1063_1064delAT; p.M355fs*14; 1:145994092-145994093	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.229C>T; p.L77F; 1:145996038-145996038	urinary_tract; bladder	carcinoma	Substitution - Missense
c.229C>T; p.L77F; 1:145996038-145996038	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.81G>T; p.V27V; 1:145996186-145996186	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.456T>C; p.N152N; 1:145995159-145995159	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1049C>A; p.P350H; 1:145994107-145994107	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.738A>G; p.T246T; 1:145994637-145994637	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.143C>T; p.A48V; 1:145996124-145996124	skin	malignant_melanoma	Substitution - Missense
c.267G>C; p.V89V; 1:145995460-145995460	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.635A>C; p.K212T; 1:145994740-145994740	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.635A>C; p.K212T; 1:145994740-145994740	urinary_tract; bladder	carcinoma	Substitution - Missense
c.498G>T; p.K166N; 1:145995005-145995005	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.498G>T; p.K166N; 1:145995005-145995005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.788C>T; p.S263F; 1:145994587-145994587	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.317C>A; p.P106H; 1:145995410-145995410	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.514T>A; p.F172I; 1:145994989-145994989	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.795delG; p.G266fs*12; 1:145994580-145994580	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.886_887insT; p.G297fs*20; 1:145994382-145994383	liver	carcinoma	Insertion - Frameshift
c.930C>T; p.A310A; 1:145994339-145994339	kidney	other; neoplasm	Substitution - coding silent
c.1028G>C; p.R343P; 1:145994128-145994128	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.516C>A; p.F172L; 1:145994987-145994987	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.420G>C; p.K140N; 1:145995195-145995195	urinary_tract; bladder	carcinoma	Substitution - Missense
c.392G>A; p.R131H; 1:145995223-145995223	breast	carcinoma	Substitution - Missense
c.731C>T; p.S244L; 1:145994644-145994644	pancreas	carcinoma	Substitution - Missense
c.557G>A; p.R186K; 1:145994946-145994946	urinary_tract; bladder	carcinoma	Substitution - Missense
c.653G>T; p.R218L; 1:145994722-145994722	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.93G>C; p.V31V; 1:145996174-145996174	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.920C>A; p.S307Y; 1:145994349-145994349	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.365A>G; p.D122G; 1:145995250-145995250	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.824C>A; p.S275Y; 1:145994551-145994551	central_nervous_system; temporal_lobe	glioma; ependymoma	Substitution - Missense
c.26_27insT; p.E11fs*1; 1:145996240-145996241	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1088T>A; p.I363N; 1:145994068-145994068	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1088T>A; p.I363N; 1:145994068-145994068	large_intestine; colon	carcinoma	Substitution - Missense
c.1088T>A; p.I363N; 1:145994068-145994068	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.110A>G; p.E37G; 1:145996157-145996157	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1158_1160delCAA; p.N389delN; 1:145993867-145993869	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.463G>A; p.D155N; 1:145995152-145995152	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1158_1160delCAA; p.N389delN; 1:145993867-145993869	breast	carcinoma; ductal_carcinoma	Deletion - In frame
c.351A>C; p.K117N; 1:145995264-145995264	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4G>A; p.V2M; 1:145996263-145996263	liver	carcinoma	Substitution - Missense
c.206A>G; p.Y69C; 1:145996061-145996061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.493G>A; p.E165K; 1:145995010-145995010	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.453C>T; p.V151V; 1:145995162-145995162	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1083C>T; p.S361S; 1:145994073-145994073	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015C>G; p.P339A; 1:145994141-145994141	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.134G>A; p.R45K; 1:145996133-145996133	skin	malignant_melanoma	Substitution - Missense
c.134G>A; p.R45K; 1:145996133-145996133	skin	malignant_melanoma	Substitution - Missense
c.915A>T; p.R305S; 1:145994354-145994354	liver	carcinoma	Substitution - Missense
c.915A>T; p.R305S; 1:145994354-145994354	liver	carcinoma	Substitution - Missense
c.561A>C; p.K187N; 1:145994942-145994942	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.496_498delAAG; p.K167delK; 1:145995005-145995007	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.496_498delAAG; p.K167delK; 1:145995005-145995007	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - In frame
c.493G>T; p.E165*; 1:145995010-145995010	breast	carcinoma	Substitution - Nonsense
c.782G>C; p.R261T; 1:145994593-145994593	urinary_tract; bladder	carcinoma	Substitution - Missense
c.385_386insT; p.D130fs*1; 1:145995229-145995230	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Insertion - Frameshift
c.13A>G; p.K5E; 1:145996254-145996254	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.13A>G; p.K5E; 1:145996254-145996254	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.368A>G; p.Y123C; 1:145995247-145995247	liver	carcinoma	Substitution - Missense
c.88C>T; p.R30W; 1:145996179-145996179	skin	malignant_melanoma	Substitution - Missense
c.198T>C; p.T66T; 1:145996069-145996069	breast	carcinoma	Substitution - coding silent
c.1002T>C; p.Y334Y; 1:145994154-145994154	prostate	carcinoma	Substitution - coding silent
c.787T>C; p.S263P; 1:145994588-145994588	urinary_tract; bladder	carcinoma	Substitution - Missense
c.500A>G; p.K167R; 1:145995003-145995003	breast	carcinoma	Substitution - Missense
c.620G>T; p.R207L; 1:145994755-145994755	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1158C>T; p.L386L; 1:145993869-145993869	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.358T>C; p.C120R; 1:145995257-145995257	skin	malignant_melanoma	Substitution - Missense
c.506C>T; p.S169F; 1:145994997-145994997	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.534G>A; p.V178V; 1:145994969-145994969	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.396G>T; p.P132P; 1:145995219-145995219	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1078G>C; p.D360H; 1:145994078-145994078	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.762C>A; p.S254R; 1:145994613-145994613	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.49C>T; p.P17S; 1:145996218-145996218	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.423A>C; p.K141N; 1:145995192-145995192	pancreas	carcinoma	Substitution - Missense
c.1106A>T; p.E369V; 1:145994050-145994050	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>A; p.E194K; 1:145994795-145994795	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.622A>G; p.I208V; 1:145994753-145994753	ovary	other; neoplasm	Substitution - Missense
c.1045A>T; p.T349S; 1:145994111-145994111	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.876G>A; p.L292L; 1:145994393-145994393	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1038C>T; p.S346S; 1:145994118-145994118	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1038C>T; p.S346S; 1:145994118-145994118	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1022A>G; p.D341G; 1:145994134-145994134	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.157A>G; p.K53E; 1:145996110-145996110	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1156C>T; p.L386F; 1:145993871-145993871	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.504T>A; p.V168V; 1:145994999-145994999	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.511A>G; p.M171V; 1:145994992-145994992	breast	carcinoma	Substitution - Missense
c.536C>T; p.S179F; 1:145994967-145994967	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.6G>T; p.V2V; 1:145996261-145996261	breast	carcinoma	Substitution - coding silent
c.595G>A; p.A199T; 1:145994780-145994780	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.996C>T; p.P332P; 1:145994160-145994160	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.996C>T; p.P332P; 1:145994160-145994160	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.26C>A; p.S9Y; 1:145996241-145996241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.26C>A; p.S9Y; 1:145996241-145996241	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.26C>A; p.S9Y; 1:145996241-145996241	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.497A>G; p.K166R; 1:145995006-145995006	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.674G>A; p.G225D; 1:145994701-145994701	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.74A>G; p.E25G; 1:145996193-145996193	pancreas	carcinoma	Substitution - Missense
c.74A>G; p.E25G; 1:145996193-145996193	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.74A>G; p.E25G; 1:145996193-145996193	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense

The somatic mutations from COSMIC database