Entrez Gene

Basic Information
Gene ID	10460
Name	TACC3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.694G>A; p.A232T; 4:1728096-1728096	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1551C>T; p.A517A; 4:1731261-1731261	skin	malignant_melanoma	Substitution - coding silent
c.989C>T; p.S330F; 4:1728391-1728391	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.687G>A; p.P229P; 4:1728089-1728089	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1234G>A; p.D412N; 4:1728636-1728636	bone; femur	chondrosarcoma	Substitution - Missense
c.1134G>A; p.P378P; 4:1728536-1728536	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1793C>G; p.A598G; 4:1737285-1737285	NS	NS	Substitution - Missense
c.2206A>G; p.I736V; 4:1740969-1740969	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1091A>T; p.K364M; 4:1728493-1728493	liver	carcinoma	Substitution - Missense
c.2271C>T; p.I757I; 4:1744565-1744565	skin	malignant_melanoma	Substitution - coding silent
c.157A>G; p.M53V; 4:1723578-1723578	liver	carcinoma	Substitution - Missense
c.287T>G; p.V96G; 4:1723852-1723852	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.534T>G; p.P178P; 4:1727936-1727936	prostate	carcinoma	Substitution - coding silent
c.591C>T; p.P197P; 4:1727993-1727993	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.13G>T; p.V5F; 4:1723434-1723434	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1824A>G; p.A608A; 4:1737316-1737316	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2150C>T; p.S717F; 4:1740913-1740913	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993G>C; p.S331S; 4:1728395-1728395	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.614C>A; p.P205H; 4:1728016-1728016	thyroid	other; neoplasm	Substitution - Missense
c.2314G>C; p.E772Q; 4:1744608-1744608	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.570C>T; p.S190S; 4:1727972-1727972	skin	malignant_melanoma	Substitution - coding silent
c.2113C>T; p.L705L; 4:1740876-1740876	skin	malignant_melanoma	Substitution - coding silent
c.1170A>G; p.A390A; 4:1728572-1728572	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.645G>A; p.E215E; 4:1728047-1728047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1294C>T; p.P432S; 4:1728696-1728696	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.11A>G; p.Q4R; 4:1723432-1723432	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1767G>A; p.E589E; 4:1737259-1737259	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1886C>T; p.S629F; 4:1737647-1737647	skin	malignant_melanoma	Substitution - Missense
c.1644+10A>G; p.?; 4:1735335-1735335	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1040C>T; p.T347I; 4:1728442-1728442	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.814G>T; p.A272S; 4:1728216-1728216	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.237G>T; p.E79D; 4:1723802-1723802	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1199G>A; p.R400Q; 4:1728601-1728601	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>T; p.I106I; 4:1727720-1727720	skin	malignant_melanoma	Substitution - coding silent
c.1328C>T; p.A443V; 4:1728730-1728730	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.859G>A; p.G287S; 4:1728261-1728261	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1870delG; p.G625fs*9; 4:1737631-1737631	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.588A>C; p.T196T; 4:1727990-1727990	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.206T>G; p.I69S; 4:1723771-1723771	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2169C>T; p.S723S; 4:1740932-1740932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1662G>T; p.L554F; 4:1735748-1735748	urinary_tract; bladder	carcinoma	Substitution - Missense
c.109C>T; p.R37C; 4:1723530-1723530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2485G>A; p.D829N; 4:1744981-1744981	urinary_tract; bladder	carcinoma	Substitution - Missense
c.130G>T; p.V44L; 4:1723551-1723551	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>T; p.R37C; 4:1723530-1723530	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1184C>T; p.P395L; 4:1728586-1728586	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1249C>T; p.P417S; 4:1728651-1728651	skin	malignant_melanoma	Substitution - Missense
c.1249C>T; p.P417S; 4:1728651-1728651	skin	malignant_melanoma	Substitution - Missense
c.1249C>T; p.P417S; 4:1728651-1728651	skin	malignant_melanoma	Substitution - Missense
c.1178_1179insC; p.M396fs*17; 4:1728580-1728581	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1178_1179insC; p.M396fs*17; 4:1728580-1728581	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1178_1179insC; p.M396fs*17; 4:1728580-1728581	ovary	carcinoma; serous_carcinoma	Insertion - Frameshift
c.452A>T; p.D151V; 4:1727854-1727854	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1669C>G; p.Q557E; 4:1735755-1735755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2346C>T; p.I782I; 4:1744727-1744727	skin	malignant_melanoma	Substitution - coding silent
c.1541G>A; p.G514E; 4:1731251-1731251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1564G>C; p.E522Q; 4:1731274-1731274	urinary_tract; bladder	carcinoma	Substitution - Missense
c.569C>T; p.S190F; 4:1727971-1727971	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.569C>T; p.S190F; 4:1727971-1727971	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1409A>C; p.E470A; 4:1730910-1730910	skin	malignant_melanoma	Substitution - Missense
c.1255G>A; p.G419R; 4:1728657-1728657	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1255G>A; p.G419R; 4:1728657-1728657	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1254C>T; p.F418F; 4:1728656-1728656	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1805A>G; p.E602G; 4:1737297-1737297	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.87T>G; p.V29V; 4:1723508-1723508	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.74C>T; p.S25L; 4:1723495-1723495	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.74C>T; p.S25L; 4:1723495-1723495	breast	carcinoma	Substitution - Missense
c.443C>T; p.A148V; 4:1727845-1727845	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.443C>T; p.A148V; 4:1727845-1727845	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.60C>T; p.C20C; 4:1723481-1723481	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.60C>T; p.C20C; 4:1723481-1723481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1606G>A; p.A536T; 4:1735287-1735287	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1838T>G; p.V613G; 4:1737599-1737599	skin	malignant_melanoma	Substitution - Missense
c.2262G>C; p.L754L; 4:1744556-1744556	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1383C>T; p.S461S; 4:1728785-1728785	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.438A>T; p.P146P; 4:1727840-1727840	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2464G>A; p.E822K; 4:1744960-1744960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.824G>A; p.C275Y; 4:1728226-1728226	breast	carcinoma	Substitution - Missense
c.824G>A; p.C275Y; 4:1728226-1728226	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1709G>T; p.S570I; 4:1735795-1735795	breast	carcinoma	Substitution - Missense
c.824G>A; p.C275Y; 4:1728226-1728226	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1787G>A; p.R596Q; 4:1737279-1737279	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2428C>T; p.L810L; 4:1744809-1744809	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1235A>G; p.D412G; 4:1728637-1728637	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2090C>T; p.S697F; 4:1740853-1740853	skin	malignant_melanoma	Substitution - Missense
c.1554G>T; p.L518F; 4:1731264-1731264	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2157G>A; p.E719E; 4:1740920-1740920	skin	malignant_melanoma	Substitution - coding silent
c.1462G>A; p.E488K; 4:1731172-1731172	skin	malignant_melanoma	Substitution - Missense
c.1077G>C; p.E359D; 4:1728479-1728479	urinary_tract; bladder	carcinoma	Substitution - Missense
c.629C>T; p.S210F; 4:1728031-1728031	skin	malignant_melanoma	Substitution - Missense
c.629C>T; p.S210F; 4:1728031-1728031	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1815C>A; p.F605L; 4:1737307-1737307	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.531C>T; p.S177S; 4:1727933-1727933	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.2384C>T; p.A795V; 4:1744765-1744765	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.S177S; 4:1727933-1727933	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.531C>T; p.S177S; 4:1727933-1727933	breast	carcinoma	Substitution - coding silent
c.2210A>T; p.E737V; 4:1740973-1740973	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1942-1G>T; p.?; 4:1739701-1739701	pancreas	carcinoma	Unknown
c.2175_2194del20; p.F726fs*87; 4:1740938-1740957	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.2373G>A; p.A791A; 4:1744754-1744754	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.325G>A; p.V109M; 4:1727727-1727727	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2379G>A; p.A793A; 4:1744760-1744760	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1662G>C; p.L554F; 4:1735748-1735748	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1591G>A; p.V531I; 4:1731301-1731301	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2427G>A; p.S809S; 4:1744808-1744808	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.636_671del36; p.K225_C236delKAETPHGAEEEC; 4:1728038-1728073	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1090A>G; p.K364E; 4:1728492-1728492	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1891G>A; p.G631R; 4:1737652-1737652	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.975C>T; p.G325G; 4:1728377-1728377	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.444C>T; p.A148A; 4:1727846-1727846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.202A>G; p.R68G; 4:1723767-1723767	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.642G>A; p.A214A; 4:1728044-1728044	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.656G>A; p.G219E; 4:1728058-1728058	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.214C>A; p.P72T; 4:1723779-1723779	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1306G>T; p.E436*; 4:1728708-1728708	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.666A>G; p.E222E; 4:1728068-1728068	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1179delC; p.M396fs*65; 4:1728581-1728581	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1179delC; p.M396fs*65; 4:1728581-1728581	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1609G>T; p.E537*; 4:1735290-1735290	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2238G>A; p.L746L; 4:1744532-1744532	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1216G>A; p.D406N; 4:1728618-1728618	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2098G>T; p.E700*; 4:1740861-1740861	breast	carcinoma	Substitution - Nonsense
c.250C>T; p.Q84*; 4:1723815-1723815	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.250C>T; p.Q84*; 4:1723815-1723815	large_intestine; colon	carcinoma	Substitution - Nonsense
c.250C>T; p.Q84*; 4:1723815-1723815	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1196C>A; p.S399Y; 4:1728598-1728598	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2338_2340delGAG; p.E780delE; 4:1744719-1744721	prostate	carcinoma	Deletion - In frame
c.1608G>A; p.A536A; 4:1735289-1735289	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.470C>T; p.S157F; 4:1727872-1727872	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2038G>A; p.E680K; 4:1739978-1739978	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1866G>A; p.A622A; 4:1737627-1737627	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1436C>T; p.A479V; 4:1730937-1730937	skin	malignant_melanoma	Substitution - Missense
c.306-10C>G; p.?; 4:1727698-1727698	kidney	other; neoplasm	Unknown
c.786A>G; p.G262G; 4:1728188-1728188	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2218C>T; p.R740C; 4:1740981-1740981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1035C>T; p.G345G; 4:1728437-1728437	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2219G>A; p.R740H; 4:1740982-1740982	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.780C>T; p.C260C; 4:1728182-1728182	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

The somatic mutations from COSMIC database