Entrez Gene

Basic Information
Gene ID	10232
Name	MSLN

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.292A>G; p.T98A; 16:764135-764135	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1352C>A; p.S451Y; 16:766765-766765	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.20G>A; p.R7Q; 16:762700-762700	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1809G>A; p.E603E; 16:768649-768649	skin	malignant_melanoma	Substitution - coding silent
c.354C>T; p.L118L; 16:764700-764700	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.395C>T; p.S132L; 16:764921-764921	haematopoietic_and_lymphoid_tissue; skin	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.395C>T; p.S132L; 16:764921-764921	haematopoietic_and_lymphoid_tissue; abdomen	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1179G>T; p.E393D; 16:766439-766439	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.29T>C; p.L10S; 16:762709-762709	skin	malignant_melanoma	Substitution - Missense
c.925C>T; p.R309C; 16:766088-766088	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.925C>T; p.R309C; 16:766088-766088	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1837G>A; p.G613R; 16:768677-768677	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1108C>T; p.Q370*; 16:766368-766368	skin	malignant_melanoma	Substitution - Nonsense
c.1531G>A; p.A511T; 16:767381-767381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1860C>T; p.V620V; 16:768700-768700	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.466G>T; p.A156S; 16:764992-764992	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.571G>A; p.D191N; 16:765170-765170	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1490G>A; p.G497E; 16:766977-766977	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.341A>T; p.D114V; 16:764687-764687	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1257G>A; p.V419V; 16:766670-766670	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.461delG; p.A156fs*22; 16:764987-764987	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.461delG; p.A156fs*22; 16:764987-764987	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.23_24CC>TT; p.P8L; 16:762703-762704	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.111G>T; p.L37L; 16:763258-763258	kidney	other; neoplasm	Substitution - coding silent
c.570C>T; p.C190C; 16:765169-765169	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.870G>T; p.R290R; 16:765765-765765	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1362C>G; p.P454P; 16:766775-766775	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.185C>T; p.S62F; 16:764028-764028	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.23C>A; p.P8H; 16:762703-762703	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1826C>A; p.P609H; 16:768666-768666	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - Missense
c.1433C>T; p.P478L; 16:766920-766920	breast	carcinoma	Substitution - Missense
c.44C>T; p.T15I; 16:762724-762724	skin	malignant_melanoma	Substitution - Missense
c.1557C>T; p.L519L; 16:767407-767407	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1447G>A; p.V483I; 16:766934-766934	skin	malignant_melanoma	Substitution - Missense
c.705-2A>T; p.?; 16:765525-765525	lung	carcinoma; adenocarcinoma	Unknown
c.176C>T; p.S59F; 16:763688-763688	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.148G>A; p.G50R; 16:763660-763660	breast	carcinoma	Substitution - Missense
c.1512C>T; p.I504I; 16:766999-766999	skin	malignant_melanoma	Substitution - coding silent
c.767G>C; p.G256A; 16:765589-765589	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.867C>T; p.L289L; 16:765762-765762	skin	malignant_melanoma	Substitution - coding silent
c.714G>A; p.S238S; 16:765536-765536	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.714G>A; p.S238S; 16:765536-765536	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1858G>A; p.V620I; 16:768698-768698	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1248C>T; p.L416L; 16:766661-766661	breast	carcinoma	Substitution - coding silent
c.1801A>G; p.M601V; 16:768559-768559	thyroid	other; neoplasm	Substitution - Missense
c.1586C>T; p.A529V; 16:767436-767436	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1801A>G; p.M601V; 16:768559-768559	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1801A>G; p.M601V; 16:768559-768559	breast	carcinoma	Substitution - Missense
c.827C>T; p.S276F; 16:765722-765722	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1306G>A; p.D436N; 16:766719-766719	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.166C>G; p.P56A; 16:763678-763678	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1238G>A; p.R413Q; 16:766651-766651	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.149G>A; p.G50E; 16:763661-763661	skin	malignant_melanoma	Substitution - Missense
c.1517C>T; p.S506F; 16:767004-767004	skin	malignant_melanoma	Substitution - Missense
c.320G>A; p.R107Q; 16:764666-764666	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1326C>T; p.T442T; 16:766739-766739	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.138G>A; p.A46A; 16:763650-763650	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1538C>T; p.T513M; 16:767388-767388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.682C>A; p.Q228K; 16:765281-765281	liver	carcinoma	Substitution - Missense
c.1466G>A; p.R489H; 16:766953-766953	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.269C>A; p.A90E; 16:764112-764112	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1596G>C; p.M532I; 16:767446-767446	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>A; p.P212P; 16:765235-765235	pancreas	NS	Substitution - coding silent
c.1226C>A; p.P409H; 16:766486-766486	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1035C>T; p.T345T; 16:766198-766198	liver	carcinoma	Substitution - coding silent
c.330_331insC; p.E113fs*69; 16:764676-764677	liver	carcinoma	Insertion - Frameshift
c.54C>T; p.L18L; 16:762734-762734	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1694G>A; p.R565H; 16:768452-768452	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.54C>T; p.L18L; 16:762734-762734	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1215C>T; p.H405H; 16:766475-766475	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1216G>A; p.E406K; 16:766476-766476	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.883C>T; p.R295W; 16:765778-765778	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.801C>T; p.I267I; 16:765696-765696	skin	malignant_melanoma	Substitution - coding silent
c.349G>A; p.A117T; 16:764695-764695	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1509G>T; p.K503N; 16:766996-766996	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.820C>T; p.R274C; 16:765715-765715	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.820C>T; p.R274C; 16:765715-765715	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.310C>G; p.L104V; 16:764656-764656	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1401G>T; p.A467A; 16:766888-766888	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.242G>A; p.R81H; 16:764085-764085	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1607C>G; p.T536R; 16:767457-767457	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.839C>A; p.S280Y; 16:765734-765734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1377C>T; p.S459S; 16:766790-766790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.435G>A; p.T145T; 16:764961-764961	central_nervous_system; brain	glioma	Substitution - coding silent
c.1638G>A; p.E546E; 16:768396-768396	skin	malignant_melanoma	Substitution - coding silent
c.795+1G>A; p.?; 16:765618-765618	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.758C>T; p.P253L; 16:765580-765580	skin	malignant_melanoma	Substitution - Missense
c.1717C>T; p.R573W; 16:768475-768475	ovary	other; neoplasm	Substitution - Missense
c.1154G>A; p.R385H; 16:766414-766414	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.936C>T; p.D312D; 16:766099-766099	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.59G>A; p.S20N; 16:762739-762739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.885G>A; p.R295R; 16:765780-765780	skin	malignant_melanoma	Substitution - coding silent
c.738C>T; p.D246D; 16:765560-765560	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1236T>C; p.P412P; 16:766649-766649	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.531G>A; p.L177L; 16:765130-765130	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1608G>T; p.T536T; 16:767458-767458	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1340G>T; p.G447V; 16:766753-766753	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.375C>T; p.F125F; 16:764721-764721	skin	malignant_melanoma	Substitution - coding silent
c.1494C>T; p.S498S; 16:766981-766981	ovary	other; neoplasm	Substitution - coding silent
c.829C>A; p.R277R; 16:765724-765724	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.857G>A; p.R286Q; 16:765752-765752	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.227G>A; p.G76D; 16:764070-764070	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.928G>T; p.E310*; 16:766091-766091	liver	carcinoma	Substitution - Nonsense
c.928G>T; p.E310*; 16:766091-766091	liver	carcinoma	Substitution - Nonsense
c.1020C>T; p.N340N; 16:766183-766183	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.638G>A; p.G213E; 16:765237-765237	skin	malignant_melanoma	Substitution - Missense
c.915C>A; p.G305G; 16:766078-766078	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.199C>T; p.L67F; 16:764042-764042	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1193T>C; p.L398S; 16:766453-766453	liver	carcinoma	Substitution - Missense
c.1144G>A; p.E382K; 16:766404-766404	skin	malignant_melanoma	Substitution - Missense
c.1234C>T; p.P412S; 16:766647-766647	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1193T>C; p.L398S; 16:766453-766453	liver	carcinoma	Substitution - Missense
c.1234C>G; p.P412A; 16:766647-766647	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1820G>A; p.G607E; 16:768660-768660	skin	malignant_melanoma	Substitution - Missense
c.1889C>T; p.A630V; 16:768729-768729	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.961T>C; p.W321R; 16:766124-766124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1384C>A; p.P462T; 16:766797-766797	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1585G>T; p.A529S; 16:767435-767435	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1142C>T; p.P381L; 16:766402-766402	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1570G>A; p.V524M; 16:767420-767420	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1593C>T; p.F531F; 16:767443-767443	skin	malignant_melanoma	Substitution - coding silent
c.473A>T; p.E158V; 16:764999-764999	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.336C>T; p.P112P; 16:764682-764682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1284G>T; p.K428N; 16:766697-766697	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.215C>T; p.A72V; 16:764058-764058	breast	carcinoma	Substitution - Missense
c.215C>T; p.A72V; 16:764058-764058	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1772C>A; p.P591H; 16:768530-768530	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.874C>T; p.R292W; 16:765769-765769	ovary	carcinoma; adenocarcinoma	Substitution - Missense
c.858G>A; p.R286R; 16:765753-765753	skin	malignant_melanoma	Substitution - coding silent
c.1315G>T; p.D439Y; 16:766728-766728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.324C>T; p.L108L; 16:764670-764670	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.706C>A; p.P236T; 16:765528-765528	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.739G>A; p.A247T; 16:765561-765561	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1495G>A; p.E499K; 16:766982-766982	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1495G>A; p.E499K; 16:766982-766982	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense

The somatic mutations from COSMIC database