| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | From Entrez database: 5295 |
|---|---|
Gene ID | 5295 |
Name | PIK3R1 |
Synonym | AGM7|GRB1|IMD36|p85|p85-ALPHA;phosphoinositide-3-kinase, regulatory subunit 1 (alpha);PIK3R1;phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
Definition | PI3-kinase subunit p85-alpha|PI3K regulatory subunit alpha|phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha|phosphatidylinositol 3-kinase regulatory subunit alpha|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)|ph |
Position | 5q13.1 |
Gene Type | protein-coding |
Pathways and Diseases | From KEGG database |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | Axon guidance mediated by netrin;PANTHER;P00009 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | role of erbb2 in signal transduction and oncology;PID BioCarta;100147 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | role of pi3k subunit p85 in regulation of actin organization and cell migration;PID BioCarta;100211 |
Pathway | phospholipase c signaling pathway;PID BioCarta;100069 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | insulin signaling pathway;PID BioCarta;100124 |
Pathway | mtor signaling pathway;PID BioCarta;100101 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Pathway | G alpha (q) signalling events;PID Reactome;500436 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | nerve growth factor pathway (ngf);PID BioCarta;100096 |
Pathway | the igf-1 receptor and longevity;PID BioCarta;100115 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
Pathway | Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178 |
Pathway | IL1-mediated signaling events;PID Curated;200075 |
Pathway | nfat and hypertrophy of the heart ;PID BioCarta;100098 |
Pathway | b cell survival pathway;PID BioCarta;100228 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | regulation of bad phosphorylation;PID BioCarta;100233 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | Paxillin-dependent events mediated by a4b1;PID Curated;200117 |
Pathway | trka receptor signaling pathway;PID BioCarta;100011 |
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation;PID BioCarta;100135 |
Pathway | G alpha (12/13) signalling events;PID Reactome;500437 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Costimulation by the CD28 family;PID Reactome;500483 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | human cytomegalovirus and map kinase pathways;PID BioCarta;100149 |
Pathway | 3-phosphoinositide biosynthesis;BioCyc;PWY-6352 |
Pathway | growth hormone signaling pathway;PID BioCarta;100155 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | IGF1 pathway;PID Curated;200084 |
Pathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | transcription factor creb and its extracellular signals;PID BioCarta;100198 |
Pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages;PID BioCarta;100152 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Gab1 signalosome;PID Reactome;500514 |
Pathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis;PID BioCarta;100255 |
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | ras-independent pathway in nk cell-mediated cytotoxicity;PID BioCarta;100095 |
Pathway | thrombin signaling and protease-activated receptors;PID BioCarta;100082 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Nongenotropic Androgen signaling;PID Curated;200145 |
Pathway | corticosteroids and cardioprotection;PID BioCarta;100156 |
Pathway | tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | CD28 dependent PI3K/Akt signaling;PID Reactome;500485 |
Pathway | GPCR downstream signaling;PID Reactome;500432 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | mTOR signaling pathway;KEGG PATHWAY;hsa04150 |
Pathway | ras signaling pathway;PID BioCarta;100047 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | actions of nitric oxide in the heart;PID BioCarta;100094 |
Pathway | the co-stimulatory signal during t-cell activation;PID BioCarta;100193 |
Pathway | cxcr4 signaling pathway;PID BioCarta;100192 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | il-7 signal transduction;PID BioCarta;100125 |
Pathway | vegf hypoxia and angiogenesis;PID BioCarta;100006 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | igf-1 signaling pathway;PID BioCarta;100136 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Pathway | PDGFR-alpha signaling pathway;PID Curated;200140 |
Pathway | akt signaling pathway;PID BioCarta;100245 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | Carbohydrate digestion and absorption;KEGG PATHWAY;hsa04973 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | ctcf: first multivalent nuclear factor;PID BioCarta;100194 |
Pathway | IL2 signaling events mediated by STAT5;PID Curated;200158 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Pathway | Signaling events mediated by the Hedgehog family;PID Curated;200144 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | rac1 cell motility signaling pathway;PID BioCarta;100056 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk);PID BioCarta;100148 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Pathway | regulation of eif-4e and p70s6 kinase;PID BioCarta;100178 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | IMMUNE;GAD |
Disease | Overnutrition;FunDO |
Disease | Cancer;FunDO |
Disease | periodontitis;GAD |
External Links | |
Links to Entrez Gene | 5295 |
Links to all GeneRIF Items | 5295 |
Sequence Information | |
Nucleotide Sequence | >5295 : length: 6991 GTCGCCAGCAGCTGGAGCGGAGTTGGAGGAAGCAGCGGCAGCGGCGAGGGCGGCAGGCTA GCTGTCGGAGACGGCAAGCACGGATCGGGCACGGCCGGCGGGTCGCAGCCGGGCTGGAGG CCGGTCGGAACCGAGCGGGCAGGAGGCCACCGCTGCAGCGCGGGCCCCGCAGAGGAAGGA AGCCGGCGGGCGGGGTGAAGCTCGTGTGTGGAGTGCCACGGTACAATCAGACGACAGATG GACAGTGTGACAAAAGTGTCAGAAAGGATTGGGCCTCGCTGTGAGAGTCAGCCTGGATTC AAAGTGTTGACAAGTTGCTGAAAAGGAAGCCAGTGAGAGGACTGTGGCACGCAGAGGAAG TGGAGCCCTGTCTTCGGTCACACCATTGATGGAGGACAGATGGACAGCCGTATGGCCAGT CACCTCTCCTCTTAAACCTTTGGAGAGTGGTCCTTTGTCCTCTGCTGGACACATAATAGG AATTCTAACACATTCTCTGAATTCACTTTTCATAAAAACGTAAAATCAGACTGCTCTGTA CAACCAGGCTCAACTGTTGCATGGTAGCAGATTTGCAAACATGAGTGCTGAGGGGTACCA GTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAAGATATTGACTTGCACTTGGG TGACATATTGACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAGGA AGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAATGAAACCACAGGGGAAAGGGG GGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAAAAAATCTCGCCTCCCACACC AAAGCCCCGGCCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCAGA TGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAGCAGTTTGCCCCTCCTGACAT TGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAAAAGAAAGGTCTGGAATGTTC AACTCTATACAGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGATTG TGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCACGTTTTGGCTGACGCTTTCAA ACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCAGCCGTTTACAGTGAAATGAT TTCTTTAGCTCCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTTAT TAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTTCAGTATTTGTTAAAACATTT CTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAATGCAAGAGTACTCTCTGAAAT TTTCAGCCCTATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTCAT AAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAACGACAGCCTGCACCAGCACT GCCTCCTAAACCACCAAAACCTACTACTGTAGCCAACAACGGTATGAATAACAATATGTC CTTACAAGATGCTGAATGGTACTGGGGAGATATCTCGAGGGAAGAAGTGAATGAAAAACT TCGAGATACAGCAGACGGGACCTTTTTGGTACGAGATGCGTCTACTAAAATGCATGGTGA TTATACTCTTACACTAAGGAAAGGGGGAAATAACAAATTAATCAAAATATTTCATCGAGA TGGGAAATATGGCTTCTCTGACCCATTAACCTTCAGTTCTGTGGTTGAATTAATAAACCA CTACCGGAATGAATCTCTAGCTCAGTATAATCCCAAATTGGATGTGAAATTACTTTATCC AGTATCCAAATACCAACAGGATCAAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAA AAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATATGATAGATTATA TGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCTATTGAAGCATT TAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGA ATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGGATTATGCATAA TTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGAAGATTGGAAGA AGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATGAACAGCATTAA ACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGGTTGACTCAAAA AGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACTGAAGACCAATA TTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACATGGAATGTTGG AAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGATGGCACTTTTCT TGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTGGACGGCGAAGT AAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTT GTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTTGTGCAGCACAA CGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGGCGATGAAGCGC TTACTCTTTGATCCTTCTCCTGAAGTTCAGCCACCCTGAGGCCTCTGGAAAGCAAAGGGC TCCTCTCCAGTCTGATCTGTGAATTGAGCTGCAGAAACGAAGCCATCTTTCTTTGGATGG GACTAGAGCTTTCTTTCACAAAAAAGAAGTAGGGGAAGACATGCAGCCTAAGGCTGTATG ATGACCACACGTTCCTAAGCTGGAGTGCTTATCCCTTCTTTTTCTTTTTTTCTTTGGTTT AATTTAAAGCCACAACCACATACAACACAAAGAGAAAAAGAAATGCAAAAATCTCTGCGT GCAGGGACAAAGAGGCCTTTAACCATGGTGCTTGTTAATGCTTTCTGAAGCTTTACCAGC TGAAAGTTGGGACTCTGGAGAGCGGAGGAGAGAGAGGCAGAAGAACCCTGGCCTGAGAAG GTTTGGTCCAGCCTGGTTTAGCCTGGATGTTGCTGTGCACGGTGGACCCAGACACATCGC ACTGTGGATTATTTCATTTTGTAACAAATGAACGATATGTAGCAGAAAGGCACGTCCACT CACAAGGGACGCTTTGGGAGAATGTCAGTTCATGTATGTTCAGAAGAAATTCTGTCATAG AAAGTGCCAGAAAGTGTTTAACTTGTCAAAAAACAAAAACCCAGCAACAGAAAAATGGAG TTTGGAAAACAGGACTTAAAATGACATTCAGTATATAAAATATGTACATAATATTGGATG ACTAACTATCAAATAGATGGATTTGTATCAATACCAAATAGCTTCTGTTTTGTTTTGCTG AAGGCTAAATTCACAGCGCTATGCAATTCTTAATTTTCATTAAGTTGTTATTTCAGTTTT AAATGTACCTTCAGAATAAGCTTCCCCACCCCAGTTTTTGTTGCTTGAAAATATTGTTGT CCCGGATTTTTGTTAATATTCATTTTTGTTATCCTTTTTTAAAAGTAAATGTACAGGATG CCAGTAAAAAAAAAAAATGGCTTCAGAATTAAAACTATGAAATATTTTACAGTTTTTCTT GTACAGAGTACTTGGCTGTTAGCCCAAGGTTAAAAAGTTCATAACAGATTTTTTTTGGAC TGTTTTGTTGGGCAGTGCCTGATAAGCTTCAAAGCTGCTTTATTCAATAAAAAAAAGAAA TGAAAAAGATATATGAATATGACAAAGTATTGCTGAGTCCAACAATGTTGTTTTAAGACT CTTAAAATACGGTACCTGGCAATGTTTATTTCATAAAGAATTGTGAACTTCTTGAATCTA GGGAGGGGGAATGTAGTGAAGGGATGTATCAAGTGGGGTGGTGGGAGGGGGAGGCAAGGT TATATGCACTTTCTCATGATTTACAGAGAAGTGAATAACTGCAAAGTGAAGTTGCTTCTT CTACTTCAGTCTTCTCTCACTTTGATTTGCTAGTTGTTATCAATTAATGACAATTACAAA CCTACTGTATCTCTAATACAGTGTGACTGGTCAGGTATTTCAGTTCTTAGGAAGGAAGTG CCAAGTTTGTTTTTGGGTTCCTGGAACAGCGCTCACCTTTGTTTAGAACACTGGTTTAAA GGGATAATCATCTCTGTCACATTAGACTATCCATCATGACCAGCAAATACTCATTTTAGG AAAAAAAAAAGCATGATCTGAAAAATACTTTTGGTGGTATGTTGGTTACCCTCCTAGCTT TCCATTTGGTTTAGAACATAAAGCAAATAGACACAGTCATACTGTCACTGCTCTGGACTG TGTGGAGCTCGCTAAAGTCATGGTCATTGCAGGAATCCAAGTGGCAGTCCTTCTCATTCA TTCTAATCATTGTATGTGCTTCACTACGGGGGGGAGAAGGAAACGTTAGCATCATGTTTC CCATTTAGGGCAGGAGTGAGAGGTCTCTCTTCCTGATTTAGATATGCAAAAGCTGGTATG TTCAGTAGGAACTGTACATGTGTTGGGAGGCATAAAGACTAATTAGCAACCATAATATGG TCACTACCCTAATAGACTAAATGAAATCTTGCAATTTCAAATTACTCTTTCTCCATATTA GATTTACCCACAGCTATATTTCTGTTTAAGTACTAGGGTGAGGGTTTTCTGTTACTTTGT TTTTTAATGTTGTTCCTTTTGAAAGAATCAGTCTTGCAGCTGAGTGAAAAATCTGTGGAA TGTATTATTTGTCCTCTTTACATGAAACTACTCATACTTAAGCAAAAGTCAGTCTTATAG CAAGACTGTTAGCCCTCAAACTTGACTCTACTGATCTGACCATTTCCCTCTCATCGCCAG ACAACTGACGATTTCCCTGGTTTTAGTCTGCGTCTCTGCTTTAAAGTTATTGTGATATCC TTCTAGATCATACACAAGTCTAACAGTTAATTAGTTAACAGTTTTTAAACTAGGTTTGTG GGTATTTTTTTGGTAGCACATGTATGCTATTACATACAAATTTTTATTTCTAAAATATAA GATCTGAGATTGAATATTTTCATTAAAAGCTACAGTTTTGTGAATCTTTGTGCTTCAACA TTCTTTGCAAGATGATACGGTATTTAGGCATTTGCCTTATTTTTGCATCTCACAAACATA AGTGCAATAGATCTTTTCATTGAACAGCAAAGTAGGATTCATCATTCCATATGACTTGAG TTACACCAGACCTGTTCTGCCCAATGCCTTTTTGATTACAGTGTAGCTTGCCCACCGCAT TTGTCGTTTTAGATACTTTGCTAGCCGGCCACTTTGGATTTCATCAGACAGTCCTAACAA TATTGTCTGAACGGCTGAATATGAATAGATACAGCAGAGGCACTCCTGATATATGATTTT TATCCATGCGTCAGTTTTTCCCACCCAGTGTAGCATCCTAAAGATAAAGCCAGAAGCTAA GCTGCAGTGAGGCTGTGATTGGGCGTAGAAGTGGGAGCATTGGGACCTCACATTACACAC ACGAGAGATCATAACCATGTGAAAAGGCAAAAAGCATGTGTTTGCAACATCTGATAACTT CATGGCCTTTGATAAATGTATATATGTATATGTGCATGGACTGTGTTTCCAGTACACCTT TCAGCCAAAACAGATCCACAGTAGTTGTTGAGTTCAAGTACATAAAGTACATAACAAGCG AACGTCTAGTACAATTCTTACTTATGTGTATGGGATTTTTCCCTTTGAGGTTGCTTTGTT TTGTCTTACAAAGGTGAAAATTGTTTGTAAGTGAAGTGAGAAGTTCATATTTCTTTGGCT TTTTTGTGTTTTTAAAAGTTACTCCTTTTAGGGAGCTGGTCTGATGACTTGCTTAGCTTG GAAATCCTTGTTTTCAGTGTGTCGAGTCAAAATGTGTTTATGTGAGCTGTCACTGTGGGG AACCAATTGCTTTGTCATATAGCTGGTTATGAACTAGTAACATGTTTGGGAAGTCCTACT GATGTTCCTTTGGAAGAAAAAATCTGCTGGTTTTAACAACTGTGCTTTTGCTATGTATGG TATCCAAGTTAGTTGAAACGCAGACACTGAGATCTGTTTGAGTTTAGGGTCATTTTTAGA AAGGGGCAGTTTAAAGCACAATGTCTCACATGGGACAAAGTTCCAAAATGCCAAATTCTT ATTTTTTAAAAAGCTAGTTCTATAAAATACTGGTATTATGGGTGGGGAGGAAATAGAATT GAGTCAATTGGAAAGACTATCCAACTTAACATGAAACTTGTCACCATGAGATAGCATTAG CTGCCCAGGATGCTGCTATATATATATATATATATATATATGTGTGTGTGTGTGTGTGTG TGTGTGTATATATATATATATATATATATATATATATATATATATATGTGTGTGTATATA TATATATATGTGTATATATATATGTATATACATATATGTATATATATGCACATATATATA TGTATTTAAAAAAATCAAAACAAAAAAAAACTCATTTATACCTGTGTATTTTTTAAAGCT ACAATCTGTTCAATGTTTTTAAAAATCTGTTTATATGACATTGTTAAAATAAAGTTGGTC TTTTGACGAGAGGGAGGATGTCACGGTCAGTTGTAACTTTGCCTTCACAAGGCAACTGGG GTGGGGGGTGGGGGTAGTGTGCCTCCTTGACATTTCGTTCAAGTTATAGATTCAATGGAG CTATGTCTTGTTTTAAGTTGCTTTAATGCATTGTATTAGATCTTCAAACAGAATAAAGGT TGTTTTGAAACTGAAAAAAAAAAAAAAAAAA |