| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 898 |
Name | CCNE1 |
Synonymous | cyclin E1;CCNE1;cyclin E1 |
Definition | G1/S-specific cyclin-E1|cyclin E variant ex5del|cyclin E variant ex7del|cyclin Es|cyclin Et |
Position | 19q12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Cdk2(h) + cyclinE1(h) <==> Cdk2(h):cyclinE1(h) (binding) | cyclinE1(h) + p27Kip1(h) <==> cyclinE1(h):p27Kip1(h) (binding) | parkin(m.s.) + cyclinE1(h) <==> parkin(m.s.):cyclinE1(h) (binding) | cycE(h) --> cyclinE1(h) (expression). | AR-isoform1(h) --> cyclinE1(h) (increase of abundance) | EGF(h) --> cyclinE1(h) (increase of abundance) | PC3(h) --/ cyclinE1(h) (decrease of abundance) | cycE(h) --> cyclinE1L(h) (expression). | cycE(h) --> Cyclin E1-E1S(h) (expression). | cycE(h) --> cyclinE1(h) (expression). | hsa-miR-15b --/ cyclinE1(h) (translational repression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 77 | Phosphothreonine. | Swiss-Prot 53.0 | 387 | Phosphoserine. | Swiss-Prot 53.0 | 395 | Phosphothreonine (by GSK3). | Swiss-Prot 53.0 | 399 | Phosphoserine (by CDK2). | Swiss-Prot 53.0 | 395 | Phosphothreonine (GSK-3beta;CD) | 8861947;14536078 | Phospho.ELM 6.0 | 399 | Phosphoserine (CDK2) | 14536078 | Phospho.ELM 6.0 | 77 | Phosphothreonine | 15364936 | Phospho.ELM 6.0 | 103 | Phosphoserine | 15364936 | Phospho.ELM 6.0 | 387 | Phosphoserine | 15364936 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr19 |
Promoter: 34993241 - 34995241 | Agilent_014791 |
chr19 |
Promoter: 34993901 - 34995901 | Agilent_014791 |
chr19 |
Promoter: 34993241 - 34995241 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 34993901 - 34995901 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 34993901 - 34995901 | GSE27584 |
chr19 |
Promoter: 34993241 - 34995241 | GSE27584 |
chr19 |
Promoter: 34993241 - 34995241 | Agilent_014791_44K |
chr19 |
Promoter: 34993241 - 34995241 | Agilent_014791 |
chr19 |
Promoter: 34993901 - 34995901 | Agilent_014791 |