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Cell senescence database
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Basic Information

Gene ID

7528

Name

YY1

Synonymous

YY1 transcription factor;YY1;YY1 transcription factor

Definition

INO80 complex subunit S|YY-1|Yin and Yang 1 protein|delta transcription factor|transcriptional repressor protein YY1

Position

14q

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

YY1(h) --> DBH(h) (DNA binding).
YY1(h) --> TP53(h) (DNA binding; transactivation).
YY1(h) --> IFNG(h) (DNA binding).
YY1(h) --> CSF2(h) (DNA binding).
YY1(h) --> SURF-1/SURF-2(h) (DNA binding).
YY1(h) --/ SAA1(r) (DNA binding; transrepression)
YY1(h) --> Csn2(r) (DNA binding).
YY1(h) --> G-ACT 5C(x) (DNA binding).
YY1(h) --> IAP LTR(m) (DNA binding).
YY1(h) --> Mo-MuLV(MOMLV) (DNA binding).
YY1(h) --> P5(AAV) (DNA binding).
YY1(h) --> IFNA7(h) (DNA binding).
YY1(h) --> MLC(r) (DNA binding).
YY1(h) --> rpL30(m) (DNA binding).
YY1(h) --> HBE1(h) (DNA binding).
YY1(h) --> IgH(m) (DNA binding).
YY1(h) --> MuLV(MULV) (DNA binding).
YY1(h) --/ SA-ACT(c) (DNA binding; transrepression).
YY1(h) --> FOS(h) (DNA binding).
YY1(h) --> Fos(m) (DNA binding).
YY1(h) + c-Myc(h) <==> YY1(h):c-Myc(h) (binding).
YY1(h) + TAF(II)55(h) <==> YY1(h):TAF(II)55(h) (binding).
p300(h) + YY1(h) <==> p300(h):YY1(h) (binding).
YY1(h) + HDAC1(h) <==> YY1(h):HDAC1(h) (binding)
YY1(h) + hdac2(h) <==> YY1(h):hdac2(h) (binding).
YAF2(h) + YY1(h) <==> YAF2(h):YY1(h) (binding).
YY1(h) + HDAC3(h) <==> YY1(h):HDAC3(h) (binding)
YY1(h) --> Apbb1(r) (DNA binding; transactivation).
Sp1(h) + YY1(h) <==> Sp1(h):YY1(h) (binding).
YY1(h) --/ DMD(h) (DNA binding; transrepression).
YY1(h) + p53(h) <==> YY1(h):p53(h) (binding)
YY1(h) --/ CAA(c) (DNA binding; transrepression).
YY1(h) --> PAX2(m) (DNA binding).
YY1(h) --> NAT1(h) (DNA binding).
PARP(h) + YY1(h) <==> PARP(h):YY1(h) (binding)
YY1(h) --> PARP1(h) (DNA binding)
YY1(h) + NAD --PARP(h)--> YY1(h){drib} + nicotinamide (ADP-ribosylation)
ATF-a(h) + YY1(h) <==> ATF-a(h):YY1(h) (binding)
YY1(h) + ATFa-isoform1(h) <==> YY1(h):ATFa-isoform1(h) (binding)
YY1(h) + ATFa-isoform3(h) <==> YY1(h):ATFa-isoform3(h) (binding)
YY1(h) + ATF-2(h) <==> YY1(h):ATF-2(h) (binding)
YY1(h) + ATF(h) <==> YY1(h):ATF(h) (binding)
YY1(h) + acetyl-CoA --p/CAF(m.s.)--> YY1(h){ace} + CoA (acetylation)
YY1(h) + acetyl-CoA --p300(m.s.)--> YY1(h){ace} + CoA (acetylation)
YY1(h) + acetyl-CoA --> YY1(h){aceK} + CoA (acetylation)
YY1(h) + hdac2(h) <==> YY1(h):hdac2(h) (binding)
YY1(h) --> STAR(h) (DNA binding).
YY1(h) + MTA1L1(m.s.) <==> YY1(h):MTA1L1(m.s.) (binding)
YY1(h) --> Rb1(m) (DNA binding).
YY1(h) --> YY1(h) (expression).
YY1(h){ace} --HDAC1(h)--> YY1(h) + acetyl (deacetylation)
YY1(h){ace} --hdac2(m.s.)--> YY1(h) + acetyl (deacetylation)
YY1(h){ace} --hdac2(h)--> YY1(h) + acetyl (deacetylation)
YY1(h){ace} --HDAC1(h)--> YY1(h) + acetyl (deacetylation)
NF-E(h) --> GLOB-AG(h) (DNA binding).
YY1(h) --> NF-E(h) (expression).
YY1(h) --> KIR3DL1(h) (DNA binding).
YY1(h) --> ATP2C1(h) (DNA binding; transactivation).
YY1(h) --> HSD3B2(h) (DNA binding; transactivation).
YY1(h) --> HSD3B1(h) (DNA binding).
YY1(h) + c-Jun(h) <==> YY1(h):c-Jun(h) (binding)
YY1(h) --> THBS1(h) (DNA binding).
YY1(h) --> cdc6(h) (transactivation)
YY1(h) --> CYBB(h) (DNA binding; transactivation).
YY1(h) --> Scarb1(r) (DNA binding).
YY1(h) --> CLC(h) (DNA binding).
YY1(h) --> DEK(h) (DNA binding).
YY1(h) --> CETP(h) (DNA binding).
FKBP25(h) + YY1(h) <==> FKBP25(h):YY1(h) (binding)
FKBP25(m.s.) + YY1(h) <==> FKBP25(m.s.):YY1(h) (binding)
YY1(h) --> DBH(h) (DNA binding).
YY1(h) --> FAS(h) (DNA binding).
YY1(h) --> HOXB7(h) (DNA binding).
YY1(h) --> GAA(h) (DNA binding; transregulation).
YY1(h) --> PCNA(h) (DNA binding).
YY1(h) --> GDF5(h) (DNA binding).
YY1(h) --> ID1(h) (DNA binding).
YY1(h) --> FCER1A(h) (DNA binding).
YY1(h) --> CDKN2A(h) (DNA binding).
YY1(h) --> BAT1(h) (DNA binding).
YY1(h) --> TOP3A(h) (DNA binding).
YY1(h) --> PEG3(h) (DNA binding).
YY1(h) + NICD1(h) <==> YY1(h):NICD1(h) (binding)
NICD1(h) + YY1(h) <==> NICD1(h):YY1(h) (binding)
NICD1(h) + YY1(h) + alpha-enolase-isoform2(h) <==> NICD1(h):YY1(h):alpha-enolase-isoform2(h) (binding)
NICD1(h) + YY1(h) + alpha-enolase(h) <==> NICD1(h):YY1(h):alpha-enolase(h) (binding)
YY1(h) --> NPM1(h) (DNA binding).
YY1(h) --> cdc25C(h) (DNA binding).
YY1(h) --> BDKRB1(h) (DNA binding).
YY1(h) --> SOD1(r) (DNA binding).
YY1(h) --> Sfrs5(m) (DNA binding).
YY1(h) --> PREPL(h) (DNA binding).
YY1(h) --> C2orf34(h) (DNA binding).
hdac2(h){p} + YY1(h) <==> hdac2(h){p}:YY1(h) (binding)
HDAC1(h) + YY1(h) <==> HDAC1(h):YY1(h) (binding)
HDAC3(m.s.) + YY1(h) <==> HDAC3(m.s.):YY1(h) (binding)
YY1(h) --> HBG1(c) (DNA binding).
YY1(h) --> Cbx5(h) (transactivation)
YY1(h) --/ mdm2(m.s.) (transrepression)
YY1(h) --/ p53(h){ace} (decrease of acetylation)
YY1(h) --> p53(h){ub(n)} (increase of ubiquitination)
YY1(h) --/ p53(h):p300(h) (decrease of abundance)
YY1(h) --> p53(h):mdm2(m.s.) (increase of abundance)
YY1(h) + mdm2(m.s.) <==> YY1(h):mdm2(m.s.) (binding)
YY1(h) --> HSPA5(h) (DNA binding).
YY1(h) --> Vil1(m) (DNA binding).
YY1(h) --> YY1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

118Phosphoserine.Swiss-Prot 53.0
247Phosphoserine.Swiss-Prot 53.0
247Phosphoserine15302935Phospho.ELM 6.0
118Phosphoserine16565220Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr14

Promoter: 99773355 - 99775355Agilent_014791

chr14

Promoter: 99773355 - 99775355GSE27584

chr14

Promoter: 99773355 - 99775355Agilent_014791_44K


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