Entrez Gene

Basic Information
Gene ID	699
Name	BUB1
Synonymous	BUB1 mitotic checkpoint serine/threonine kinase;BUB1;BUB1 mitotic checkpoint serine/threonine kinase
Definition	BUB1 budding uninhibited by benzimidazoles 1 homolog\|budding uninhibited by benzimidazoles 1 homolog\|mitotic checkpoint serine/threonine-protein kinase BUB1\|mitotic spindle checkpoint kinase\|putative serine/threonine-protein kinase
Position	2q14
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
Bub3(h) + Bub1(h) <==> Bub3(h):Bub1(h) (binding)
Bub1(h) + plk1(h) <==> Bub1(h):plk1(h) (binding)
Bub1(h) + ATP --> Bub1(h){pT609} + ADP (phosphorylation)
Bub1(h) + 2 ATP --cyclinB1(h):Cdk1(h)--> Bub1(h){pS593}{pT609} + 2 ADP (phosphorylation)
Bub1(h) --> protein remnants (degradation)
rae1(h) + Bub1(h) <==> rae1(h):Bub1(h) (binding)
Bub1(h) + n ATP --> Bub1(h){p}n + n ADP (phosphorylation)
Bub1(h) + crk(h) <==> Bub1(h):crk(h) (binding)
Bub1(h) + Ari-2(h) <==> Bub1(h):Ari-2(h) (binding)
BUB1(h) --> Bub1(h) (expression).
DDB1(h) --/ Bub1(h) (decrease of abundance)
Cdc20(h) + ATP --Bub1(h)--> Cdc20(h){p} + ADP (phosphorylation)
Bub1(h) + plk1(h) <==> Bub1(h):plk1(h) (binding)
Bub1(h) + ATP --plk1(h)--> Bub1(h){p} + ADP (phosphorylation)
Bub1(h) --> protein remnants (degradation)
Bub1(h) + n ubiquitin(h) --cyclosome(x):Cdc20(h)--> Bub1(h){ub}n (ubiquitination)
Bub1(h) + n ubiquitin(h) --cyclosome(x):Fzr1(h)--> Bub1(h){ub}n (ubiquitination)
Bub1(h) + ATP --> Bub1(h){p} + ADP (phosphorylation; automodification)
BUB1(h) --> Bub1(h) (expression).
Cdc20(h) + ATP --Bub1(h)--> Cdc20(h){p} + ADP (phosphorylation)
Cdc20(h) + 6 ATP --Bub1(h)--> Cdc20(h){pS41}{pS72}{pS92}{pS153}{pT157}{pS161} + 6 ADP (phosphorylation)

Post Transcriptional Modification [Top]
	There is no record for BUB1

Transcription Factors [Top]