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Cell senescence database
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Basic Information

Gene ID

6778

Name

STAT6

Synonymous

signal transducer and activator of transcription 6, interleukin-4 induced;STAT6;signal transducer and activator of transcription 6, interleukin-4 induced

Definition

STAT, interleukin4-induced|signal transducer and activator of transcription 6|transcription factor IL-4 STAT

Position

12q13

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

STAT6(h) + ATP --Jak1(h)--> STAT6(h){pY} + ADP (phosphorylation)
IRF-9(h) + STAT6(h) + STAT2(h) <==> IRF-9(h):STAT6(h):STAT2(h) (binding)
p300(h) + STAT6(h) <==> p300(h):STAT6(h) (binding)
CBP(m) + STAT6(h) <==> CBP(m):STAT6(h) (binding)
IL-4Ralpha(h){pY} + STAT6(h) <==> IL-4Ralpha(h){pY}:STAT6(h) (binding)
snd1(h) + STAT6(h) <==> snd1(h):STAT6(h) (binding)
STAT6(h) + snd1(h) + RNA polymerase II(h) <==> STAT6(h):snd1(h):RNA polymerase II(h) (binding)
SRC-1(m) + STAT6(h) <==> SRC-1(m):STAT6(h) (binding)
STAT6(h) --> ALOX15(h) (DNA binding).
STAT6(h) + ATP --> STAT6(h){pY} + ADP (phosphorylation)
STAT6(h) --> CCL17(h) (DNA binding; transactivation).
ErbB1-p170(h){pY1016} + STAT6(h) <==> ErbB1-p170(h){pY1016}:STAT6(h) (binding)
ErbB2(h){pY1023}{pY1139}{pY1222} + STAT6(h) <==> ErbB2(h){pY1023}{pY1139}{pY1222}:STAT6(h) (binding)
ErbB3-isoform1(h) + STAT6(h) <==> ErbB3-isoform1(h):STAT6(h) (binding)
STAT6(h) + 2 ATP --> STAT6(h){pS}{pY} + 2 ADP (phosphorylation)
STAT6(h) --> IL1RN(h) (DNA binding).
STAT6(h) --> FCER2(h) (DNA binding).
STAT6(h) --> IGHE(h) (DNA binding).
STAT6(h) --> IRF4(h) (DNA binding).
STAT6(h) --> CCL26(h) (DNA binding).
STAT6(h) --> SOCS1(h) (DNA binding).
STAT6(h) --> SELP(h) (DNA binding).
STAT6(h) + ATP --> STAT6(h){p} + ADP (phosphorylation)
STAT6(h) --> FCGR1A(h) (DNA binding).
STAT6(h) --> CYSLTR1(h) (DNA binding).
STAT6(h) --> LTC4S(h) (DNA binding).
STAT6(h) --> CSN2(b) (DNA binding).
STAT6(h) --> Igh-7(m) (DNA binding).
STAT6(h) --> STAT6(h) (expression).
STAT6-isoform1(h) --> A2-Mag(r) (DNA binding).
STAT6-isoform1(h) --> FCGR1A(h) (DNA binding).
STAT6-isoform1(h) --> IL-2Ralpha(h) (DNA binding).
STAT6-isoform1(h) --> IL-2Ralpha(m) (DNA binding).
STAT6-isoform1(h) --> IL4R(h) (DNA binding).
STAT6-isoform1(h) --> OPRM1(h) (DNA binding; transregulation).
STAT6-isoform1(h) --> IGHE(h) (DNA binding).
STAT6-isoform1(h) --> ALOX15(h) (transactivation)
STAT6-isoform1(h) + ATP --> STAT6-isoform1(h){pY641} + ADP (phosphorylation)
STAT6-isoform1(h) --> Chi3l3(m) (transactivation)
STAT6(h) --> STAT6-isoform1(h) (expression).
STAT6-xbb1(h) + litaf-isoform2(h) <==> STAT6-xbb1(h):litaf-isoform2(h) (binding)
STAT6(h) --> STAT6-xbb1(h) (expression).
STAT6(h) --> STAT6-isoform2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

641Phosphotyrosine (by JAK) (By similarity).Swiss-Prot 53.0
645Phosphothreonine15069079Phospho.ELM 6.0
756Phosphoserine15523052Phospho.ELM 6.0

Methylation Profile   [Top]

There is no record for STAT6



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