| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5879 |
Name | RAC1 |
Synonymous | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1);RAC1;ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
Definition | cell migration-inducing gene 5 protein|ras-like protein TC25|ras-related C3 botulinum toxin substrate 1 |
Position | 7p22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Rac1(h) + GTP <==> Rac1(h):GTP (binding) | IL-1RI(h) + Rac1(h) <==> IL-1RI(h):Rac1(h) (binding) | Rac1(h) --Caspase-3(h)--> protein remnants (processing) | Rac1(h) --Caspase-7(h)--> protein remnants (processing) | Rac1(h) + RhoGDI-1(h) <==> Rac1(h):RhoGDI-1(h) (binding) | Rac1(h) + Arfaptin 2(h) <==> Rac1(h):Arfaptin 2(h) (binding) | RhoGDI(h) + Rac1(h) <==> RhoGDI(h):Rac1(h) (binding) | Rac1(h) + p67phox(h) <==> Rac1(h):p67phox(h) (binding) | Rac1(h) + p47phox(h) <==> Rac1(h):p47phox(h) (binding) | Rac1(h) + IQGAP1(h) <==> Rac1(h):IQGAP1(h) (binding) | Rac1(h) --Caspase-8(h)--> protein remnants (cleavage) | Rac1(h) --Caspase-3(h)--> Rac1-p16(h) + Rac1-p20(h) + protein remnants (cleavage) | Rac1(h) + GDP <==> GDP:Rac1(h) (binding) | Rac1(h) + FHOS(h) <==> Rac1(h):FHOS(h) (binding) | Rac1(h) + caveolin-1(h) <==> Rac1(h):caveolin-1(h) (binding) | Rac1(h) --> mmp1(h) (increase of abundance) | Rac1(h) + CAPRI(m) <==> Rac1(h):CAPRI(m) (binding) | Rac1(h) + synaptojanin 2(h) <==> Rac1(h):synaptojanin 2(h) (binding) | Rac1(h) + BPGAP1(h) <==> Rac1(h):BPGAP1(h) (binding) | p65PAK(h) + Rac1(h) <==> p65PAK(h):Rac1(h) (binding) | Rac1(h) --> p65PAK(h){p} (increase of phosphorylation) | Rac1(h) + Vav(h) <==> Rac1(h):Vav(h) (binding) [re. | Rac1(h) + Vav(h) <==> Rac1(h):Vav(h) (binding) [re. | BNIP-2(h) + Rac1(h) <==> BNIP-2(h):Rac1(h) (binding) | TLR2(h) + Rac1(h) <==> TLR2(h):Rac1(h) (binding) | Rac1(h) + ARF6(h) <==> Rac1(h):ARF6(h) (binding) | Rac1(h) + cd2ap(h) <==> Rac1(h):cd2ap(h) (binding) | cd2ap(h) + Rac1(h) <==> cd2ap(h):Rac1(h) (binding) | CAPZ(h) + Rac1(h) <==> CAPZ(h):Rac1(h) (binding) | c-Cbl(h) + Rac1(h) <==> c-Cbl(h):Rac1(h) (binding) | cortactin(h) + Rac1(h) <==> cortactin(h):Rac1(h) (binding) | cd2ap(h) + Rac1(h) <==> cd2ap(h):Rac1(h) (binding) | Nischarin(m) --/ Rac1(h) (inhibition) | RAC1(h) --> Rac1(h) (expression). | STAU1(h) --> Rac1(h) (binding) | Syk(h) --> Rac1(h) (activation) | LAMA5(h) --> Rac1(h) (activation) | RAC1(h) --> rac1-isoform2(h) (expression). | cd2ap(m.s.) + rac1-isoform1(h) <==> cd2ap(m.s.):rac1-isoform1(h) (binding) | cd2ap(h) + rac1-isoform1(h) <==> cd2ap(h):rac1-isoform1(h) (binding) | RAC1(h) --> rac1-isoform1(h) (expression). | RAC1(h) --> Rac1-xbb1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 39 | ADP-ribosylasparagine (by botulinumtoxin) (By similarity). | Swiss-Prot 53.0 | 189 | Cysteine methyl ester. | Swiss-Prot 53.0 | 189 | S-geranylgeranyl cysteine. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr7 |
Promoter: 6379151 - 6381151 | Agilent_014791 |
chr7 |
Promoter: 6379151 - 6381151 | GSE27584 |
chr7 |
Promoter: 6379151 - 6381151 | GSE27584 |
chr7 |
Promoter: 6379151 - 6381151 | Agilent_014791_44K |
chr7 |
Promoter: 6379151 - 6381151 | Agilent_014791 |